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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
MGI:1342774
145 phenotypes from 11 alleles in 20 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Ppargc1aem1(IMPC)Bay/\Ppargc1aem1(IMPC)Bay
C57BL/6N-Ppargc1aem1(IMPC)Bay/BayMmucd 		preweaning lethality, incomplete penetrance J:211773
\Ppargc1atm1.1Amos/\Ppargc1atm1.1Amos
involves: C57BL/6JOlaHsd 		abnormal crypts of Lieberkuhn morphology J:171361
abnormal small intestinal villus morphology J:171361
increased incidence of tumors by chemical induction J:171361
increased tumor growth/size J:171361
\Ppargc1atm1.1Javi/\Ppargc1atm1.1Javi
\Tg(Fabp4-cre)1Rev/0
B6.Cg-Ppargc1atm1.1Javi Tg(Fabp4-cre)1Rev 		abnormal brown fat cell morphology J:180984
normal adipose tissue phenotype J:180984
decreased body weight J:180984
decreased brown fat cell size J:180984
decreased liver weight J:180984
decreased total body fat amount J:180984
decreased white fat cell size J:180984
\Ppargc1atm1Aztc/\Ppargc1a+
C57BL/6-Ppargc1atm1Aztc 		decreased body length J:82809
decreased body weight J:82809
decreased bone mineral content J:82809
decreased circulating cholesterol level J:82809
decreased food intake J:82809
decreased lean body mass J:82809
decreased respiratory quotient J:82809
decreased retroperitoneal fat pad weight J:82809
increased adrenal gland weight J:82809
increased circulating alkaline phosphatase level J:82809
increased kidney weight J:82809
increased thymus weight J:82809
thrombocytopenia J:82809
\Ppargc1atm1Aztc/\Ppargc1atm1Aztc
C57BL/6-Ppargc1atm1Aztc 		decreased body fat mass J:82809
decreased body weight J:82809
decreased circulating glucose level J:82809
decreased circulating insulin level J:82809
decreased lean body mass J:82809
\Ppargc1atm1Brsp/\Ppargc1a+
involves: 129 * FVB/N 		normal immune system phenotype J:127403
\Ppargc1atm1Brsp/\Ppargc1a+
involves: 129S4/SvJae * C57BL/6 		abnormal Bruch membrane morphology J:264271
abnormal choriocapillaris morphology J:264271
abnormal choroid vasculature morphology J:264271
abnormal melanosome transport J:264271
abnormal mitochondrial physiology J:264271
abnormal retina pigment epithelium morphology J:264271
decreased mitochondrial DNA content J:264271
impaired autophagy J:264271
increased inflammatory response J:264271
lipofuscinosis J:264271
oxidative stress J:264271
retina macular degeneration J:264271
retina photoreceptor degeneration J:264271
short photoreceptor inner segment J:264271
short photoreceptor outer segment J:264271
\Ppargc1atm1Brsp/\Ppargc1atm1Brsp
involves: 129 * FVB/N 		cachexia J:111072
congestive heart failure J:111072
increased heart weight J:111072
increased interleukin-6 secretion J:127403
increased lung weight J:111072
increased response of heart to induced stress J:111072
\Ppargc1atm1Brsp/\Ppargc1atm1Brsp
involves: 129/Sv * C57BL/6 * FVB/N 		abnormal brown adipose tissue morphology J:93896
abnormal cellular respiration J:93896
abnormal gluconeogenesis J:93896
abnormal glucose homeostasis J:93896
abnormal lipid homeostasis J:93896
abnormal neuron morphology J:93896
anhedonia J:213551
decreased circulating insulin level J:93896
decreased liver triglyceride level J:93896
decreased susceptibility to diet-induced obesity J:93896
dystonia J:93896
gliosis J:93896
hyperactivity J:93896
hypoglycemia J:93896
impaired adaptive thermogenesis J:93896
improved glucose tolerance J:93896
increased insulin sensitivity J:93896
increased oxygen consumption J:93896
increased startle reflex J:93896
increased susceptibility to induced morbidity/mortality J:93896
limb grasping J:93896
myoclonus J:93896
postnatal lethality, incomplete penetrance J:93896
spongiform encephalopathy J:93896
\Ppargc1atm1Brsp/\Ppargc1atm2Brsp
\Tg(Myog-cre)1Eno/0
involves: 129 * C57BL/6 * FVB/N 		abnormal glucose homeostasis J:127403
abnormal mitochondrial physiology J:127403
abnormal pancreatic beta cell morphology J:127403
decreased body weight J:127403
decreased circulating insulin level J:127403
decreased food intake J:127403
decreased percent body fat/body weight J:127403
decreased respiratory quotient J:127403
decreased susceptibility to diet-induced obesity J:127403
normal endocrine/exocrine gland phenotype J:127403
enlarged pancreatic islets J:127403
normal homeostasis/metabolism phenotype J:127403
hyperglycemia J:127403
impaired glucose tolerance J:127403
increased basal metabolism J:127403
increased circulating glucose level J:127403
increased circulating interleukin-6 level J:127403
increased oxygen consumption J:127403
increased pancreatic beta cell mass J:127403
\Ppargc1atm1Dpk/\Ppargc1atm1Dpk
B6.129X1-Ppargc1atm1Dpk/J 		abnormal substantia nigra morphology J:298664
bradykinesia J:298664
decreased locomotor activity J:298664
decreased nervous system dopamine level J:298664
impaired coordination J:298664
neurodegeneration J:298664
\Ppargc1atm1Dpk/\Ppargc1atm1Dpk
involves: 129X1/SvJ 		abnormal blood circulation J:137598
abnormal brown adipose tissue morphology J:137598
abnormal fat cell morphology J:137598
decreased triglyceride level J:137598
\Ppargc1atm1Dpk/\Ppargc1atm1Dpk
involves: 129X1/SvJ * C57BL/6 		abnormal basal ganglion morphology J:96306
abnormal body weight J:96306
abnormal brainstem morphology J:96306
abnormal cellular respiration J:96306
abnormal cerebellum morphology J:96306
abnormal cerebral cortex morphology J:96306
abnormal hippocampus morphology J:96306
abnormal liver physiology J:96306
abnormal locomotor behavior J:96306
abnormal skeletal muscle fiber morphology J:96306
decreased cardiac output J:96306
decreased gastrocnemius weight J:96306
decreased grip strength J:96306
decreased heart left ventricle muscle contractility J:96306
decreased heart rate J:96306
decreased heart weight J:96306
decreased oxygen consumption J:96306
decreased skeletal muscle weight J:96306
decreased soleus weight J:96306
fatigue J:96306
hepatic steatosis J:96306
impaired adaptive thermogenesis J:96306
improved glucose tolerance J:96306
increased insulin sensitivity J:96306
increased muscle fatigability J:96306
increased percent body fat/body weight J:96306
increased susceptibility to weight gain J:96306
increased thigmotaxis J:96306
increased total body fat amount J:96306
\Ppargc1atm2.1Brsp/\Ppargc1atm2.1Brsp
involves: 129 		abnormal behavioral response to amphetamine J:234906
decreased dopamine level J:234906
decreased dopaminergic neuron number J:234906
\Ppargc1atm2.1Brsp/\Ppargc1atm2.1Brsp
\Tg(Adipoq-cre)1Evdr/0
B6.Cg-Ppargc1atm2.1Brsp Tg(Adipoq-cre)1Evdr 		abnormal fat cell mitochondrial morphology J:363192
abnormal white adipose tissue physiology J:363192
decreased fat cell mitochondrial DNA content J:363192
\Ppargc1atm2.1Brsp/\Ppargc1atm2.1Brsp
\Tg(Myog-cre)1Eno/0
involves: 129 * BALB/c * C57BL/6J * C57BL/6N 		abnormal mitochondrial physiology J:208380
decreased circulating glucose level J:208380
decreased circulating insulin level J:208380
decreased lean body mass J:208380
decreased respiratory quotient J:208380
normal growth/size/body region phenotype J:208380
impaired glucose tolerance J:208380
increased percent body fat/body weight J:208380
insulin resistance J:208380
\Ppargc1atm2Brsp/\Ppargc1a+
\Tg(Myog-cre)1Eno/0
involves: 129 * C57BL/6 		normal behavior/neurological phenotype J:127403
normal growth/size/body region phenotype J:127403
normal homeostasis/metabolism phenotype J:127403
impaired glucose tolerance J:127403
increased circulating glucose level J:127403
increased circulating interleukin-6 level J:127403
\Ppargc1atm2Brsp/\Ppargc1atm2Brsp
involves: 129 		male infertility J:127403
\Ppargc1atm2Brsp/\Ppargc1atm2Brsp
\Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+
involves: 129 * C57BL/6 * DBA 		abnormal blood homeostasis J:115197
abnormal cell physiology J:115197
\Tg(Ckm-Ppargc1a)31Brsp/0
C57BL/6-Tg(Ckm-Ppargc1a)31Brsp 		abnormal depression-related behavior J:213551
abnormal muscle physiology J:78333
abnormal skeletal muscle morphology J:78333
\Tg(Ckm-Ppargc1a)31Brsp/0
C57BL/6-Tg(Ckm-Ppargc1a)31Brsp/J 		abnormal aerobic respiration J:176080
increased mitochondrial fission J:176080
\Tg(Myh6-rtTA)8585Jam/0
\Tg(tetO-Ppargc1a)1Dpk/0
involves: FVB/N * FVB/NTac 		abnormal heart left ventricle morphology J:96614
abnormal mitochondrial morphology J:96614
abnormal myocardial fiber morphology J:96614
cardiac hypertrophy J:96614
cardiomyopathy J:96614
decreased cardiac muscle contractility J:96614
decreased heart rate J:96614
dilated heart left ventricle J:96614
dilated heart right ventricle J:96614
increased heart rate J:96614
increased mitochondrial fission J:96614
\Tg(Myog-Ppargc1a_i4)#Brsp/0
Not Specified 		decreased body fat mass J:211329
decreased epididymal fat pad weight J:211329
decreased subcutaneous adipose tissue amount J:211329
decreased susceptibility to diet-induced obesity J:211329
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory