Spop Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Spop
speckle-type BTB/POZ protein
MGI:1343085

31 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Spop^{Gt(BGB118)Byg}/Spop⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal pancreatic beta cell physiology	J:165268
	abnormal pancreatic islet cell apoptosis	J:165268
	normal endocrine/exocrine gland phenotype	J:165268
	normal homeostasis/metabolism phenotype	J:165268
Spop^{Gt(BGB118)Byg}/Spop^{Gt(BGB118)Byg} involves: 129P2/OlaHsd * C57BL/6	increased pancreatic beta cell mass	J:165268
	perinatal lethality, complete penetrance	J:165268
Spop^{tm1a(KOMP)Mbp}/Spop^{tm1a(KOMP)Mbp} involves: C57BL/6N	neonatal lethality, complete penetrance	J:239074
Spop^{tm1b(KOMP)Wtsi}/Spop⁺ C57BL/6N-Spop^{tm1b(KOMP)Wtsi}/Tcp	decreased food intake	J:211773
	decreased grip strength	J:211773
	decreased prepulse inhibition	J:211773
	decreased respiratory quotient	J:211773
	enlarged lymph nodes	J:211773
	increased circulating aspartate transaminase level	J:211773
	small adrenal glands	J:211773
	small thymus	J:211773
Spop^{tm1b(KOMP)Wtsi}/Spop^{tm1b(KOMP)Wtsi} C57BL/6N-Spop^{tm1b(KOMP)Wtsi}/Tcp	preweaning lethality, complete penetrance	J:211773
Spop^{tm1c(KOMP)Mbp}/Spop^{tm1c(KOMP)Mbp} Tg(Prrx1-cre)1Cjt/0 involves: C57BL/6J * C57BL/6N * SJL/J	abnormal bone ossification	J:239074
	abnormal femur morphology	J:239074
	abnormal trabecular bone morphology	J:239074
	brachydactyly	J:239074
	brachyphalangia	J:239074
	decreased bone mass	J:239074
	decreased bone mineral density	J:239074
	decreased bone trabecula number	J:239074
	decreased bone volume	J:239074
	decreased length of long bones	J:239074
	decreased trabecular bone connectivity density	J:239074
	decreased trabecular bone mass	J:239074
	decreased trabecular bone thickness	J:239074
	short metacarpal bones	J:239074
	short metatarsal bones	J:239074
Spop^{tm1d(KOMP)Mbp}/Spop^{tm1d(KOMP)Mbp} involves: C57BL/6N * FVB/N	neonatal lethality, complete penetrance	J:239074

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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