Robo3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Robo3
roundabout guidance receptor 3
MGI:1343102

26 phenotypes from 4 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dbx1^tm2(cre)Apie/Dbx1⁺ Robo3^tm1.1Ache/Robo3^tm1.1Ache involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	abnormal medulla oblongata morphology	J:165285
	abnormal pre-Botzinger complex morphology	J:165285
	abnormal pre-Botzinger complex physiology	J:165285
	neonatal lethality, complete penetrance	J:165285
Egr2^tm2(cre)Pch/Egr2⁺ Robo3^tm1.1Ache/Robo3^tm1.1Ache involves: 129S2/SvPas	abnormal auditory brainstem response	J:158918
	abnormal brain commissure morphology	J:158918
	abnormal horizontal vestibuloocular reflex	J:158918
	abnormal innervation	J:158918
	abnormal optokinetic reflex	J:158918
	abnormal reflex	J:158918
Egr2^tm2(cre)Pch/Egr2⁺ Robo3^tm1.1Ache/Robo3^tm1.1Ache Tg(Mnx1-EGFP)#Tmj/0 involves: 129S2/SvPas * C57BL/6 * DBA	abnormal pons morphology	J:158918
Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Robo3^tm1.1Ache/Robo3^tm1.1Ache involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	abnormal brain commissure morphology	J:158918
	abnormal innervation	J:158918
	abnormal motor coordination/balance	J:158918
	ataxia	J:158918
	impaired coordination	J:158918
Robo3^em1(IMPC)H/Robo3⁺ C57BL/6NTac-Robo3^em1(IMPC)H/H	abnormal retina morphology	J:211773
	increased circulating bilirubin level	J:211773
	increased heart weight	J:211773
Robo3^em1(IMPC)H/Robo3^em1(IMPC)H C57BL/6NTac-Robo3^em1(IMPC)H/H	preweaning lethality, complete penetrance	J:211773
Robo3^m1J/Robo3^m1J C57BL/6J-Robo3^m1J/GrsrJ	ataxia	J:178742
	impaired balance	J:178742
	normal mortality/aging	J:178742
Robo3^tm1Matl/Robo3⁺ Tg(Atoh1-lacZ)1Jejo/? Not Specified	abnormal dorsal interneuron 1 morphology	J:142117
Robo3^tm1Matl/Robo3^tm1Matl either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)	abnormal axon guidance	J:89438
	abnormal floor plate morphology	J:89438
	perinatal lethality, complete penetrance	J:89438
Robo3^tm1Matl/Robo3^tm1Matl involves: C57BL/6	abnormal breathing pattern	J:165285
	abnormal pre-Botzinger complex physiology	J:165285
	cyanosis	J:165285
	neonatal lethality, complete penetrance	J:165285
Robo3^tm1Matl/Robo3^tm1Matl Not Specified	abnormal brain commissure morphology	J:158918
Robo3^tm1Matl/Robo3^tm1Matl Tg(Mnx1-EGFP)#Tmj/0 involves: C57BL/6 * DBA	abnormal pons morphology	J:158918

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24