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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Zeb1
zinc finger E-box binding homeobox 1
MGI:1344313
189 phenotypes from 9 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Zeb1m1Btlr/Zeb1m1Btlr
involves: C57BL/6J 		abnormal B cell differentiation J:185495
abnormal class switch recombination J:185495
abnormal memory B cell physiology J:185495
absent marginal zone B cells J:185495
decreased B cell proliferation J:185495
decreased B-1 B cell number J:185495
decreased B-1a cell number J:185495
decreased B-1b cell number J:185495
decreased double-positive T cell number J:185495
decreased germinal center B cell number J:185495
decreased IgG1 level J:185495
decreased IgG level J:185495
decreased IgM level J:185495
decreased NK cell number J:185495
normal immune system phenotype J:185495
increased single-positive T cell number J:185495
increased thymocyte number J:185495
Zeb1m2Btlr/Zeb1m2Btlr
C57BL/6J-Zeb1m2Btlr 		impaired humoral immune response J:221490
Zeb1tm1.1Ajg/Zeb1tm1.1Ajg
C57BL/6-Zeb1tm1.1Ajg 		abnormal semicircular canal morphology J:177274
absent lateral semicircular canal J:177274
cleft palate J:177274
decreased cochlea coiling J:177274
decreased posterior semicircular canal size J:177274
Zeb1tm1.1Ajg/Zeb1tm2.1Ajg
C57BL/6-Zeb1tm1.1Ajg/Zeb1tm2.1Ajg 		abnormal circulating hormone level J:177274
abnormal circulating lipid level J:177274
abnormal eating behavior J:177274
abnormal semicircular canal morphology J:177274
normal behavior/neurological phenotype J:177274
decreased locomotor activity J:177274
decreased oxygen consumption J:177274
enlarged otoliths J:177274
impaired glucose tolerance J:177274
increased body weight J:177274
increased circulating adiponectin level J:177274
increased circulating corticosterone level J:177274
increased circulating free fatty acids level J:177274
increased circulating insulin level J:177274
increased circulating leptin level J:177274
increased circulating triglyceride level J:177274
increased percent body fat/body weight J:177274
increased total body fat amount J:177274
insulin resistance J:177274
Zeb1tm1.1Ajg/Zeb1Tw
B6.Cg-Zeb1tm1.1Ajg/Zeb1Tw 		abnormal cochlea morphology J:177274
abnormal semicircular canal morphology J:177274
cleft palate J:177274
Zeb1tm1.1Mpst/Zeb1tm1.1Mpst
involves: C57BL/6 		no abnormal phenotype detected J:239147
Zeb1tm1.2Mpst/Zeb1tm1.2Mpst
involves: C57BL/6 * CBA 		abnormal cranial blood vasculature morphology J:239147
abnormal hindlimb morphology J:239147
curly tail J:239147
cyclopia J:239147
edema J:239147
fetal growth retardation J:239147
hemorrhage J:239147
hydrops fetalis J:239147
perinatal lethality, complete penetrance J:239147
respiratory failure J:239147
Zeb1tm1Yhi/Zeb1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal cornea stroma morphology J:135179
abnormal iridocorneal angle J:135179
anterior iris synechia J:135179
increased cornea thickness J:135179
Zeb1tm1Yhi/Zeb1tm1Yhi
B6.129P2-Zeb1tm1Yhi 		abnormal T cell differentiation J:39865
abnormal T cell subpopulation ratio J:39865
abnormal thymus development J:39865
decreased CD8-positive, alpha-beta T cell number J:39865
decreased double-positive T cell number J:39865
decreased lymphocyte cell number J:39865
decreased splenocyte number J:39865
decreased T cell number J:39865
decreased thymocyte number J:39865
lymph node hypoplasia J:39865
postnatal lethality, incomplete penetrance J:39865
small thymus J:39865
thymus hypoplasia J:39865
Zeb1tm1Yhi/Zeb1tm1Yhi
either: (involves: 129 * C3H * C57BL/6) or (involves: 129 * C57BL/6 * ICR) 		ascites J:139194
increased T cell derived lymphoma incidence J:139194
premature death J:139194
Zeb1tm1Yhi/Zeb1tm1Yhi
involves: 129P2/OlaHsd * C57BL/6 		abnormal cornea endothelium morphology J:135179
abnormal cornea stroma morphology J:135179
abnormal iridocorneal angle J:135179
anterior iris synechia J:135179
cornea abrasion J:135179
cornea epithelium hypoplasia J:135179
increased cornea thickness J:135179
neonatal lethality, complete penetrance J:135179
Zeb1tm2Yhi/Zeb1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal vascular wound healing J:110800
Zeb1tm2Yhi/Zeb1tm2Yhi
B6.129-Zeb1tm2Yhi 		abnormal basisphenoid bone morphology J:45575
abnormal craniofacial bone morphology J:45575
abnormal elbow joint morphology J:45575
abnormal hip joint morphology J:45575
abnormal jaw morphology J:45575
abnormal lateral semicircular canal morphology J:177274
abnormal mandibular angle morphology J:45575
abnormal nasal septum morphology J:45575
abnormal navicular morphology J:45575
abnormal phalanx morphology J:45575
abnormal pterygoid bone morphology J:45575
abnormal rib morphology J:45575
abnormal serous gland morphology J:45575
abnormal sternebra morphology J:45575
abnormal sternum morphology J:45575
abnormal tarsal bone morphology J:45575
abnormal xiphoid process morphology J:45575
bowed radius J:45575
bowed tibia J:45575
brachyphalangia J:45575
cleft secondary palate J:45575
curly tail J:45575
cyanosis J:45575
decreased length of long bones J:45575
decreased thymocyte number J:45575
delayed endochondral bone ossification J:45575
exencephaly J:45575
fetal growth retardation J:45575
fused carpal bones J:45575
fused metatarsal bones J:45575
hemorrhage J:45575
hydrops fetalis J:45575
intervertebral disk hypoplasia J:45575
mandible hypoplasia J:45575
mandibular condyloid process hypoplasia J:45575
mandibular coronoid process hypoplasia J:45575
Meckel's cartilage hyperplasia J:45575
neonatal lethality, complete penetrance J:45575
open neural tube J:45575
palate bone hypoplasia J:45575
patellar dislocation J:45575
respiratory failure J:45575
rib fusion J:45575
short limbs J:45575
short mandible J:45575
short maxilla J:45575
short premaxilla J:45575
short scapula J:45575
short sternum J:45575
syndactyly J:45575
thymus hypoplasia J:45575
Zeb1tm2Yhi/Zeb1tm2Yhi
involves: 129S1/Sv * 129X1/SvJ 		abnormal vascular smooth muscle physiology J:110800
Zeb1tm2Yhi/Zeb1Tw
B6.Cg-Zeb1tm2Yhi/Zeb1Tw 		abnormal lateral semicircular canal morphology J:177274
circling J:177274
Zeb1Tw/Zeb1+
B6.Cg-Zeb1Tw 		abnormal circulating hormone level J:177274
abnormal circulating lipid level J:177274
abnormal cochlea morphology J:177274
abnormal lateral semicircular canal morphology J:177274
abnormal semicircular canal morphology J:177274
circling J:177274
decreased leukocyte cell number J:177274
decreased lymphocyte cell number J:177274
decreased neutrophil cell number J:177274
enlarged otoliths J:177274
impaired glucose tolerance J:177274
increased body weight J:177274
increased circulating adiponectin level J:177274
increased circulating corticosterone level J:177274
increased circulating free fatty acids level J:177274
increased circulating insulin level J:177274
increased circulating leptin level J:177274
increased circulating triglyceride level J:177274
increased food intake J:177274
increased or absent threshold for auditory brainstem response J:177274
increased percent body fat/body weight J:177274
insulin resistance J:177274
obese J:177274
small spleen J:177274
small thymus J:177274
Zeb1Tw/Zeb1+
involves: C57BL/6J 		abnormal inner ear morphology J:60496
bidirectional circling J:60496
decreased body size J:60496
diluted coat color J:60496
female infertility J:60496
hyperactivity J:60496
increased susceptibility to age related obesity J:60496
reduced male fertility J:60496
sparse hair J:60496
transmission ratio distortion J:60496
Zeb1Tw/Zeb1+
STOCK PCS 		abnormal abdominal fat pad morphology J:274
abnormal crista ampullaris morphology J:274
abnormal crista ampullaris neuroepithelium morphology J:274
abnormal inguinal fat pad morphology J:274
abnormal inner ear canal morphology J:274
abnormal otolith morphology J:274
abnormal parental behavior J:274
abnormal posterior semicircular canal morphology J:274
abnormal postural reflex J:274
abnormal scala media morphology J:274
abnormal semicircular canal ampulla morphology J:274
abnormal superior semicircular canal morphology J:274
absent otoliths J:274
circling J:274
decreased lateral semicircular canal size J:274
decreased otolith number J:274
dilated endolymphatic duct J:274
head bobbing J:274
head shaking J:274
normal hearing/vestibular/ear phenotype J:274
increased aggression towards male mice J:274
increased susceptibility to age related obesity J:274
increased total body fat amount J:274
infertility J:274
postnatal growth retardation J:274
Zeb1Tw/Zeb1Tw
B6.Cg-Zeb1Tw 		absent lateral semicircular canal J:177274
cleft palate J:177274
decreased cochlea coiling J:177274
decreased posterior semicircular canal size J:177274
Zeb1Tw/Zeb1Tw
involves: C57BL/6J 		abnormal inner ear morphology J:60496
abnormal nasal cavity morphology J:60496
abnormal palatal shelf morphology J:60496
abnormal premaxilla morphology J:60496
abnormal turbinate morphology J:60496
bilateral cleft upper lip J:60496
cleft palate J:60496
cleft secondary palate J:60496
cleft upper lip J:60496
decreased palatal shelf size J:60496
distended abdomen J:60496
midline facial cleft J:60496
neonatal lethality, complete penetrance J:60496
palatal shelves fail to meet at midline J:60496
turbinate hypoplasia J:60496
unilateral cleft upper lip J:60496
Zeb1Tw/Zeb1Tw
Not Specified 		abnormal cribriform plate morphology J:73312
abnormal ethmoid bone morphology J:73312
abnormal nasal cavity morphology J:73312
abnormal nasal septum morphology J:73312
abnormal olfactory bulb glomerular layer morphology J:73312
abnormal olfactory bulb layer morphology J:73312
abnormal olfactory bulb mitral cell layer morphology J:73312
abnormal olfactory bulb morphology J:73312
abnormal olfactory epithelium morphology J:73312
abnormal olfactory nerve morphology J:73312
abnormal olfactory neuron innervation pattern J:73312
abnormal olfactory sensory neuron morphology J:73312
abnormal turbinate morphology J:73312
cleft secondary palate J:73312
unilateral cleft upper lip J:73312
Zeb1Tw/Zeb1Tw
STOCK PCS 		abnormal inner ear morphology J:274
abnormal maxillary shelf morphology J:274
abnormal suckling behavior J:274
bilateral cleft palate J:274
bilateral cleft upper lip J:274
cleft palate J:274
cleft upper lip J:274
median cleft palate J:274
meteorism J:274
neonatal lethality, complete penetrance J:274
respiratory distress J:274
unilateral cleft palate J:274
unilateral cleft upper lip J:274
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory