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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Grem1
gremlin 1, DAN family BMP antagonist
MGI:1344337
59 phenotypes from 6 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Grem1ld-J/Grem1ld-J
involves: CBA/Ca 		abnormal ureteric bud elongation J:17401
absent kidney J:17401
single kidney J:17401
Grem1ld/Grem1ld
involves: 129S1/SvImJ or CD-1 		abnormal pulmonary alveolus morphology J:91385
absent kidney J:91385
absent ureter J:91385
Grem1ld/Grem1ld
Not Specified 		abnormal fibula morphology J:22159
abnormal kidney morphology J:17401
abnormal limb bud morphology J:46539
abnormal long bone morphology J:22158, J:22159
abnormal metanephric mesenchyme morphology J:17401
abnormal tibia morphology J:22159
abnormal ureteric bud elongation J:17401
absent kidney J:17401, J:22158
fused radius and ulna J:22159
oligodactyly J:22158
renal hypoplasia J:22158
single kidney J:17401
syndactyly J:22158
Grem1tm1Azun/Grem1tm1Azun
either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1) 		abnormal apical ectodermal ridge morphology J:90991
abnormal limb development J:90991
abnormal limb long bone morphology J:90991
abnormal limb mesenchyme morphology J:90991
abnormal lung epithelium morphology J:90991
abnormal metanephric mesenchyme morphology J:90991
abnormal pulmonary alveolus morphology J:90991
abnormal ureteric bud elongation J:90991
abnormal ureteric bud invasion J:90991
abnormal urinary bladder morphology J:90991
absent kidney J:90991
absent metanephros J:90991
absent ureter J:90991
cyanosis J:90991
fused metacarpal bones J:90991
impaired branching involved in ureteric bud morphogenesis J:90991
increased apoptosis J:90991
increased metanephric mesenchyme apoptosis J:90991
neonatal lethality, complete penetrance J:90991
oligodactyly J:90991
respiratory distress J:90991
Grem1tm1Azun/Grem1tm1Azun
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		absent kidney J:122530
single kidney J:122530
Grem1tm1Ecan/Grem1tm1Rmh
Tg(BGLAP-cre)1Clem/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N 		enhanced osteoblast differentiation J:126375
increased bone mineralization J:126375
increased bone ossification J:126375
increased trabecular bone thickness J:126375
increased trabecular bone volume J:126375
Grem1tm1Rmh/Grem1tm1Rmh
involves: 129P2/OlaHsd 		normal renal/urinary system phenotype J:130204
normal reproductive system phenotype J:130204
Grem1tm1Rmh/Grem1tm1Rmh
involves: 129P2/OlaHsd * C57BL/6 		abnormal digit morphology J:84077
abnormal forelimb morphology J:84077
abnormal hindlimb morphology J:84077
abnormal limb morphology J:84077
absent kidney J:84077
oligodactyly J:84077
postnatal lethality, complete penetrance J:84077
syndactyly J:84077
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Grem1)Svok
involves: 129S1/Sv * 129S4/SvJae 		abnormal digit morphology J:214075
polydactyly J:214075
Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+
Tg(Prrx1-cre)1Cjt/0
involves: 129S1/Sv * C57BL/6J * SJL/J 		abnormal digit morphology J:214075
abnormal forelimb bud morphology J:214075
abnormal hallux morphology J:214075
abnormal hindlimb morphology J:214075
absent forelimb J:214075
brachydactyly J:214075
decreased apoptosis J:214075
forelimb oligodactyly J:214075
increased cell proliferation J:214075
polydactyly J:214075
syndactyly J:214075
triphalangia J:214075
Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/0
involves: 129S1/Sv 		polyphalangy J:214075
postaxial polydactyly J:214075
preaxial polydactyly J:214075
Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sor+
Tg(Hoxb6-cre/ERT)1Smac/0
involves: 129S1/Sv * FVB/N 		abnormal digit morphology J:214075
absent hindlimb J:214075
brachydactyly J:214075
polydactyly J:214075
polyphalangy J:214075
Gt(ROSA)26Sortm1(Grem1)Svok/Gt(ROSA)26Sortm1(Grem1)Svok
Tg(Hoxb6-cre/ERT)1Smac/0
involves: 129S1/Sv * FVB/N 		abnormal digit morphology J:214075
absent fibula J:214075
absent hindlimb J:214075
bowed femur J:214075
bowed tibia J:214075
brachydactyly J:214075
polydactyly J:214075
polyphalangy J:214075
short fibula J:214075
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory