Grem1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Grem1
gremlin 1, DAN family BMP antagonist
MGI:1344337

59 phenotypes from 6 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Grem1^ld-J/Grem1^ld-J involves: CBA/Ca	abnormal ureteric bud elongation	J:17401
	absent kidney	J:17401
	single kidney	J:17401
Grem1^ld/Grem1^ld involves: 129S1/SvImJ or CD-1	abnormal pulmonary alveolus morphology	J:91385
	absent kidney	J:91385
	absent ureter	J:91385
Grem1^ld/Grem1^ld Not Specified	abnormal fibula morphology	J:22159
	abnormal kidney morphology	J:17401
	abnormal limb bud morphology	J:46539
	abnormal long bone morphology	J:22158, J:22159
	abnormal metanephric mesenchyme morphology	J:17401
	abnormal tibia morphology	J:22159
	abnormal ureteric bud elongation	J:17401
	absent kidney	J:17401, J:22158
	fused radius and ulna	J:22159
	oligodactyly	J:22158
	renal hypoplasia	J:22158
	single kidney	J:17401
	syndactyly	J:22158
Grem1^tm1Azun/Grem1^tm1Azun either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	abnormal apical ectodermal ridge morphology	J:90991
	abnormal limb development	J:90991
	abnormal limb long bone morphology	J:90991
	abnormal limb mesenchyme morphology	J:90991
	abnormal lung epithelium morphology	J:90991
	abnormal metanephric mesenchyme morphology	J:90991
	abnormal pulmonary alveolus morphology	J:90991
	abnormal ureteric bud elongation	J:90991
	abnormal ureteric bud invasion	J:90991
	abnormal urinary bladder morphology	J:90991
	absent kidney	J:90991
	absent metanephros	J:90991
	absent ureter	J:90991
	cyanosis	J:90991
	fused metacarpal bones	J:90991
	impaired branching involved in ureteric bud morphogenesis	J:90991
	increased apoptosis	J:90991
	increased metanephric mesenchyme apoptosis	J:90991
	neonatal lethality, complete penetrance	J:90991
	oligodactyly	J:90991
	respiratory distress	J:90991
Grem1^tm1Azun/Grem1^tm1Azun involves: 129S1/Sv * 129X1/SvJ * C57BL/6	absent kidney	J:122530
	single kidney	J:122530
Grem1^tm1Ecan/Grem1^tm1Rmh Tg(BGLAP-cre)1Clem/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N	enhanced osteoblast differentiation	J:126375
	increased bone mineralization	J:126375
	increased bone ossification	J:126375
	increased trabecular bone thickness	J:126375
	increased trabecular bone volume	J:126375
Grem1^tm1Rmh/Grem1^tm1Rmh involves: 129P2/OlaHsd	normal renal/urinary system phenotype	J:130204
Grem1^tm1Rmh/Grem1^tm1Rmh involves: 129P2/OlaHsd	normal reproductive system phenotype	J:130204
Grem1^tm1Rmh/Grem1^tm1Rmh involves: 129P2/OlaHsd * C57BL/6	abnormal digit morphology	J:84077
	abnormal forelimb morphology	J:84077
	abnormal hindlimb morphology	J:84077
	abnormal limb morphology	J:84077
	absent kidney	J:84077
	oligodactyly	J:84077
	postnatal lethality, complete penetrance	J:84077
	syndactyly	J:84077
Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor^{tm1(Grem1)Svok} involves: 129S1/Sv * 129S4/SvJae	abnormal digit morphology	J:214075
	polydactyly	J:214075
Gt(ROSA)26Sor^{tm1(Grem1)Svok}/Gt(ROSA)26Sor⁺ Tg(Prrx1-cre)1Cjt/0 involves: 129S1/Sv * C57BL/6J * SJL/J	abnormal digit morphology	J:214075
	abnormal forelimb bud morphology	J:214075
	abnormal hallux morphology	J:214075
	abnormal hindlimb morphology	J:214075
	absent forelimb	J:214075
	brachydactyly	J:214075
	decreased apoptosis	J:214075
	forelimb oligodactyly	J:214075
	increased cell proliferation	J:214075
	polydactyly	J:214075
	syndactyly	J:214075
	triphalangia	J:214075
Gt(ROSA)26Sor^{tm1(Grem1)Svok}/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/0 involves: 129S1/Sv	polyphalangy	J:214075
	postaxial polydactyly	J:214075
	preaxial polydactyly	J:214075
Gt(ROSA)26Sor^{tm1(Grem1)Svok}/Gt(ROSA)26Sor⁺ Tg(Hoxb6-cre/ERT)1Smac/0 involves: 129S1/Sv * FVB/N	abnormal digit morphology	J:214075
	absent hindlimb	J:214075
	brachydactyly	J:214075
	polydactyly	J:214075
	polyphalangy	J:214075
Gt(ROSA)26Sor^{tm1(Grem1)Svok}/Gt(ROSA)26Sor^{tm1(Grem1)Svok} Tg(Hoxb6-cre/ERT)1Smac/0 involves: 129S1/Sv * FVB/N	abnormal digit morphology	J:214075
	absent fibula	J:214075
	absent hindlimb	J:214075
	bowed femur	J:214075
	bowed tibia	J:214075
	brachydactyly	J:214075
	polydactyly	J:214075
	polyphalangy	J:214075
	short fibula	J:214075

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