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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dido1
death inducer-obliterator 1
MGI:1344352
45 phenotypes from 4 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dido1tm1Cmar/Dido1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal bone marrow cell morphology/development J:101201
abnormal splenic cell ratio J:101201
abnormal splenocyte morphology J:101201
increased granulocyte number J:101201
increased monocyte cell number J:101201
increased spleen weight J:101201
spleen hyperplasia J:101201
Dido1tm1Cmar/Dido1tm1Cmar
involves: 129S1/Sv * 129X1/SvJ 		abnormal bone marrow cell morphology/development J:101201
abnormal erythropoiesis J:101201
abnormal proerythroblast morphology J:101201
abnormal splenic cell ratio J:101201
abnormal splenocyte morphology J:101201
anemia J:101201
normal cellular phenotype J:101201
normal hematopoietic system phenotype J:101201
normal immune system phenotype J:101201
increased erythrocyte cell number J:101201
increased granulocyte number J:101201
increased megakaryocyte cell number J:101201
increased monocyte cell number J:101201
increased spleen weight J:101201
increased spleen white pulp amount J:101201
reduced female fertility J:101201
reduced male fertility J:101201
spleen hyperplasia J:101201
Dido1tm1Cmar/Dido1tm2Cmar
involves: 129S1/Sv * 129X1/SvJ 		abnormal centrosome morphology J:183346
abnormal chromosome morphology J:183346
abnormal mitosis J:183346
aneuploidy J:183346
prenatal lethality, incomplete penetrance J:183346
Dido1tm2Cmar/Dido1tm2Cmar
involves: 129S1/Sv * 129X1/SvJ 		abnormal cell differentiation J:183346
abnormal centrosome morphology J:183346
abnormal embryonic epiblast morphology J:183346
abnormal embryonic tissue physiology J:183346
aneuploidy J:183346
decreased embryonic epiblast cell proliferation J:183346
embryonic growth arrest J:183346
embryonic lethality between somite formation and embryo turning, complete penetrance J:183346
increased embryonic epiblast cell apoptosis J:183346
Dido1tm3Cmar/Dido1tm3.1Cmar
Ndor1Tg(UBC-cre/ERT2)1Ejb/Ndor1+
involves: 129S/SvEv * C57BL/6 		abnormal hepatocyte morphology J:328215
ataxia J:328215
decreased body weight J:328215
decreased testis weight J:328215
enlarged liver J:328215
impaired coordination J:328215
increased circulating alanine transaminase level J:328215
increased circulating aspartate transaminase level J:328215
increased circulating cholesterol level J:328215
increased hepatocyte karyomegaly J:328215
liver inflammation J:328215
male infertility J:328215
seizures J:328215
small testis J:328215
testis degeneration J:328215
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory