Hcst Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hcst
hematopoietic cell signal transducer
MGI:1344360

29 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hcst^tm1.1Cln/Hcst^tm1.1Cln B6.129P2-Hcst^tm1.1Cln	abnormal long bone metaphysis morphology	J:147155
	abnormal osteoclast differentiation	J:147155
	abnormal osteoclast physiology	J:147155
	abnormal trabecular bone morphology	J:147155
	decreased osteoclast cell number	J:147155
	increased bone volume	J:147155
	osteopetrosis	J:147155
Hcst^tm1.1Cln/Hcst^tm1.1Cln involves: 129P2/OlaHsd * BALB/cJ * C57BL/6	decreased CD8-positive, alpha-beta T cell number	J:80426
	normal immune system phenotype	J:80426
	impaired natural killer cell mediated cytotoxicity	J:80426
Hcst^tm1.1Cln/Hcst^tm1.1Cln involves: 129P2/OlaHsd * C57BL/6	abnormal decidua basalis morphology	J:100668
	abnormal maternal decidual layer morphology	J:100668
	decreased interferon-gamma secretion	J:100668
	decreased uterine NK cell number	J:100668
	enlarged placenta	J:100668
	reduced fertility	J:100668
Hcst^tm1.1Dnax/Hcst^tm1.1Dnax involves: C57BL/6	abnormal NK T cell physiology	J:147867, J:148086
	abnormal response to infection	J:147867
	ascites	J:148086
	decreased incidence of tumors by chemical induction	J:148086
	decreased interferon-gamma secretion	J:147867
	decreased metastatic potential	J:148086
	decreased tumor growth/size	J:148086
	normal immune system phenotype	J:148086
	impaired natural killer cell mediated cytotoxicity	J:148086
	increased interferon-gamma secretion	J:148086
	increased interleukin-4 secretion	J:148086
	increased spleen weight	J:148086
	increased susceptibility to experimental autoimmune encephalomyelitis	J:148086
	increased susceptibility to induced morbidity/mortality	J:148086
Hcst^{tm1b(KOMP)Wtsi}/Hcst^{tm1b(KOMP)Wtsi} C57BL/6N-Hcst^{tm1b(KOMP)Wtsi}/Tcp	increased bone mineral content	J:211773
	increased bone mineral density	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24