Hcst Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hcst
hematopoietic cell signal transducer
MGI:1344360

29 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hcst^tm1.1Cln/Hcst^tm1.1Cln B6.129P2-Hcst^tm1.1Cln	abnormal long bone metaphysis morphology	J:147155
	abnormal osteoclast differentiation	J:147155
	abnormal osteoclast physiology	J:147155
	abnormal trabecular bone morphology	J:147155
	decreased osteoclast cell number	J:147155
	increased bone volume	J:147155
	osteopetrosis	J:147155
Hcst^tm1.1Cln/Hcst^tm1.1Cln involves: 129P2/OlaHsd * BALB/cJ * C57BL/6	decreased CD8-positive, alpha-beta T cell number	J:80426
	normal immune system phenotype	J:80426
	impaired natural killer cell mediated cytotoxicity	J:80426
Hcst^tm1.1Cln/Hcst^tm1.1Cln involves: 129P2/OlaHsd * C57BL/6	abnormal decidua basalis morphology	J:100668
	abnormal maternal decidual layer morphology	J:100668
	decreased interferon-gamma secretion	J:100668
	decreased uterine NK cell number	J:100668
	enlarged placenta	J:100668
	reduced fertility	J:100668
Hcst^tm1.1Dnax/Hcst^tm1.1Dnax involves: C57BL/6	abnormal NK T cell physiology	J:147867, J:148086
	abnormal response to infection	J:147867
	ascites	J:148086
	decreased incidence of tumors by chemical induction	J:148086
	decreased interferon-gamma secretion	J:147867
	decreased metastatic potential	J:148086
	decreased tumor growth/size	J:148086
	normal immune system phenotype	J:148086
	impaired natural killer cell mediated cytotoxicity	J:148086
	increased interferon-gamma secretion	J:148086
	increased interleukin-4 secretion	J:148086
	increased spleen weight	J:148086
	increased susceptibility to experimental autoimmune encephalomyelitis	J:148086
	increased susceptibility to induced morbidity/mortality	J:148086
Hcst^{tm1b(KOMP)Wtsi}/Hcst^{tm1b(KOMP)Wtsi} C57BL/6N-Hcst^{tm1b(KOMP)Wtsi}/Tcp	increased bone mineral content	J:211773
	increased bone mineral density	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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