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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Usp18
ubiquitin specific peptidase 18
MGI:1344364
26 phenotypes from 2 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Usp18ity9/Usp18ity9
involves: 129S1/SvImJ * C57BL/6 		abnormal lymphocyte morphology J:163843
anemia J:163843
decreased circulating interferon-gamma level J:163843
decreased interferon-gamma secretion J:163843
decreased leukocyte cell number J:163843
increased circulating interleukin-6 level J:163843
increased interleukin-6 secretion J:163843
increased susceptibility to bacterial infection J:163843
increased susceptibility to bacterial infection induced morbidity/mortality J:163843
increased susceptibility to endotoxin shock J:163843
thrombocytopenia J:163843
Usp18ity9/Usp18tm1Dez
involves: 129 * C57BL/6 * FVB/N 		increased susceptibility to bacterial infection J:163843
increased susceptibility to bacterial infection induced morbidity/mortality J:163843
Usp18tm1Dez/Usp18tm1Dez
involves: 129S1/Sv * 129X1/SvJ 		abnormal cerebral cortex morphology J:78821
circling J:78821
convulsive seizures J:78821
enlarged lateral ventricles J:78821
enlarged third ventricle J:78821
hydrocephaly J:78821
intracerebral hemorrhage J:78821
premature death J:78821
spinning J:78821
tremors J:78821
Usp18tm1Dez/Usp18tm1Dez
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal circulating enzyme level J:214425
abnormal cytokine level J:214425
decreased circulating interferon-alpha level J:214425
decreased circulating interferon-beta level J:214425
decreased circulating interferon-gamma level J:214425
decreased susceptibility to Coronaviridae infection J:214425
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory