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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Grem2
gremlin 2, DAN family BMP antagonist
MGI:1344367
48 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Grem2em1(IMPC)Bay/Grem2+
C57BL/6N-Grem2em1(IMPC)Bay/Bay 		dilated heart left ventricle J:211773
increased cardiac stroke volume J:211773
Grem2em1(IMPC)Bay/Grem2em1(IMPC)Bay
C57BL/6N-Grem2em1(IMPC)Bay/Bay 		preweaning lethality, incomplete penetrance J:211773
Grem2em1Stpg/Grem2em1Stpg
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J 		abnormal circulating hormone level J:318711
abnormal diestrus J:318711
abnormal estrous cycle J:318711
abnormal hormone level J:318711
abnormal ovary physiology J:318711
abnormal secondary ovarian follicle morphology J:318711
decreased corpora lutea number J:318711
decreased litter size J:318711
decreased tertiary ovarian follicle number J:318711
normal homeostasis/metabolism phenotype J:318711
increased primary ovarian follicle number J:318711
ovary inflammation J:318711
prolonged diestrus J:318711
prolonged metestrus J:318711
reduced female fertility J:318711
short estrus J:318711
short lower incisors J:318711
short upper incisors J:318711
Grem2tm1Akh/Grem2tm1Akh
involves: 129/Sv * C57BL/6 		abnormal chemokine level J:250034
abnormal response to myocardial ischemic injury J:250034
normal cardiovascular system phenotype J:250034
decreased heart left ventricle muscle contractility J:250034
increased heart rate J:250034
increased inflammatory response J:250034
increased interleukin-10 secretion J:250034
increased leukocyte cell number J:250034
increased transforming growth factor beta level J:250034
Grem2tm1Lex/Grem2tm1Lex
involves: 129S5/SvEvBrd * C57BL/6 		abnormal dentin morphology J:227246
abnormal incisor morphology J:227246
abnormal molar cusp morphology J:227246
abnormal tooth wear J:227246
normal behavior/neurological phenotype J:227246
brittle teeth J:227246
normal homeostasis/metabolism phenotype J:227246
normal immune system phenotype J:227246
increased bone mineral density J:227246
increased bone mineral density of femur J:227246
reduced enamel thickness J:227246
small lower incisors J:227246
small mandible J:227246
small upper incisors J:227246
normal vision/eye phenotype J:227246
Tg(Myh6-Grem2)1Akh/0
involves: C57BL/6 		abnormal response to myocardial ischemic injury J:250034
normal cardiovascular system phenotype J:250034
decreased inflammatory response J:250034
decreased interleukin-10 secretion J:250034
decreased transforming growth factor beta level J:250034
increased cardiac muscle contractility J:250034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory