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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnfsf13b
tumor necrosis factor (ligand) superfamily, member 13b
MGI:1344376
79 phenotypes from 7 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(Tnfsf13b)1Fma/0
B6.Cg-Tg(Tnfsf13b)1Fma 		abnormal B cell differentiation J:73711
abnormal B-1 B cell morphology J:114782
abnormal glomerular mesangium morphology J:114782
abnormal kidney morphology J:114782
abnormal spleen germinal center morphology J:114782
abnormal spleen marginal zone morphology J:114782
decreased salivation J:73711
enlarged salivary gland J:73711
increased autoantibody level J:114782
increased B cell number J:114782
increased B-1a cell number J:114782
increased B-1b cell number J:114782
increased IgA level J:114782
increased plasma cell number J:114782
increased submandibular gland tumor incidence J:73711
increased urine protein level J:114782
kidney inflammation J:73711
renal glomerular immunoglobulin deposits J:114782
renal glomerulus hypertrophy J:114782
salivary gland inflammation J:73711
Tg(Tnfsf13b)1Fma/?
B6.Cg-Tg(Tnfsf13b)1Fma 		abnormal B cell activation J:113556
abnormal marginal zone B cell physiology J:113556
abnormal spleen marginal zone morphology J:113556
glomerulonephritis J:113556
increased anti-double stranded DNA antibody level J:113556
increased B cell number J:113556
increased marginal zone B cell number J:113556
increased transitional stage B cell number J:113556
increased urine protein level J:113556
renal glomerular immunoglobulin deposits J:113556
Tg(Tnfsf13b)1Fma/0
involves: C57BL/6 * DBA/2J 		abnormal B cell morphology J:58798
abnormal B cell physiology J:58798
abnormal kidney morphology J:58798
abnormal spleen follicular dendritic cell network J:58798
abnormal spleen morphology J:58798
abnormal spleen periarteriolar lymphoid sheath morphology J:58798
abnormal T cell number J:58798
abnormal T cell physiology J:58798
abnormal T cell subpopulation ratio J:58798
enlarged lymph nodes J:58798
enlarged Peyer's patches J:58798
enlarged spleen J:58798
normal hematopoietic system phenotype J:58798
increased anti-double stranded DNA antibody level J:58798
increased anti-single stranded DNA antibody level J:58798
increased autoantibody level J:58798
increased B cell number J:58798
increased IgG level J:58798
increased IgM level J:58798
increased immunoglobulin level J:58798
increased lymphocyte cell number J:58798
increased marginal zone B cell number J:58798
increased mature B cell number J:58798
increased plasma cell number J:58798
increased spleen B cell follicle size J:58798
increased spleen germinal center size J:58798
increased T cell number J:58798
increased urine protein level J:58798
Tg(Tnfsf13b)1Fma/0
involves: C57BL/6J * DBA/2J 		abnormal B cell differentiation J:115788
abnormal B-1 B cell morphology J:115788
Tg(Tnfsf13b)1Fma/Tg(Tnfsf13b)1Fma
involves: C57BL/6 * DBA/2 		abnormal immunoglobulin level J:178227
abnormal kidney physiology J:178227
abnormal mesangial cell morphology J:178227
abnormal renal glomerulus morphology J:178227
albuminuria J:178227
expanded mesangial matrix J:178227
increased B cell number J:178227
increased IgA level J:178227
increased IgM level J:178227
increased immunoglobulin level J:178227
increased marginal zone B cell number J:178227
increased transitional stage T2 B cell number J:178227
increased urine protein level J:178227
kidney inflammation J:178227
premature death J:178227
renal glomerulus atrophy J:178227
Tnfsf13bm1Anu/Tnfsf13bm1Anu
C57BL/6JAnu-Tnfsf13bm1Anu/AnuApb 		abnormal B cell differentiation J:104190
decreased mature B cell number J:104190
increased immature B cell number J:104190
Tnfsf13bM1Btlr/Tnfsf13b+
C57BL/6J-Tnfsf13bM1Btlr 		decreased B cell number J:220069
decreased IgG level J:220069
decreased IgM level J:220069
impaired humoral immune response J:220069
increased single-positive T cell number J:220069
increased T cell number J:220069
Tnfsf13bM1Btlr/Tnfsf13bM1Btlr
C57BL/6J-Tnfsf13bM1Btlr 		decreased B cell number J:220069
decreased IgG level J:220069
decreased IgM level J:220069
impaired humoral immune response J:220069
increased single-positive T cell number J:220069
increased T cell number J:220069
Tnfsf13bm2Btlr/Tnfsf13bm2Btlr
C57BL/6J-Tnfsf13bm2Btlr 		decreased B cell number J:220070
decreased IgG level J:220070
impaired humoral immune response J:220070
Tnfsf13bm3Btlr/Tnfsf13bm3Btlr
C57BL/6J-Tnfsf13bm3Btlr 		abnormal lymphocyte morphology J:272850
decreased B cell number J:272850
Tnfsf13btm1Cleg/Tnfsf13btm1Cleg
involves: 129S5/SvEvBrd 		abnormal B cell differentiation J:71301
abnormal B cell physiology J:71301
abnormal leukocyte morphology J:71301
abnormal lymph organ size J:71301
decreased follicular B cell number J:71301
decreased IgG level J:71301
decreased IgM level J:71301
decreased mature B cell number J:71301
decreased memory T cell number J:71301
increased T cell number J:71301
lymph node hypoplasia J:71301
spleen hypoplasia J:71301
Tnfsf13btm1Msc/Tnfsf13b+
involves: 129S2/SvPas * C57BL/6 		decreased immunoglobulin level J:71681
Tnfsf13btm1Msc/Tnfsf13btm1Msc
involves: 129S2/SvPas 		decreased B cell number J:138560
decreased follicular B cell number J:138560
decreased T cell proliferation J:92334
decreased transitional stage B cell number J:138560
increased length of allograft survival J:92334
Tnfsf13btm1Msc/Tnfsf13btm1Msc
involves: 129S2/SvPas * C57BL/6 		abnormal B cell differentiation J:71681
abnormal humoral immune response J:71681
abnormal lymph node B cell domain morphology J:71681
arrested B cell differentiation J:71681
decreased B cell number J:71681
decreased follicular B cell number J:71681
decreased immunoglobulin level J:71681
decreased marginal zone B cell number J:71681
decreased spleen weight J:71681
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/17/2024
MGI 6.24 		The Jackson Laboratory