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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Chd4
chromodomain helicase DNA binding protein 4
MGI:1344380
42 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Chd4em1Flc/Chd4+
Not Specified 		abnormal heart right ventricle morphology J:338019
Chd4em1Flc/Chd4em1Flc
C57BL/6J-Chd4em1Flc 		abnormal fetal cardiomyocyte physiology J:338019
abnormal heart echocardiography feature J:338019
abnormal heart morphology J:338019
abnormal heart ventricle morphology J:338019
abnormal myocardial fiber morphology J:338019
abnormal myocardial trabeculae morphology J:338019
abnormal skeletal muscle fiber morphology J:338019
abnormal Z line morphology J:338019
decreased heart left ventricle muscle contractility J:338019
decreased heart rate J:338019
decreased skeletal muscle fiber number J:338019
increased cardiac jelly amount J:338019
increased fetal cardiomyocyte number J:338019
increased fetal cardiomyocyte proliferation J:338019
increased skeletal muscle fiber size J:338019
increased width of hypertrophic chondrocyte zone J:338019
neonatal lethality, incomplete penetrance J:338019
postnatal lethality, complete penetrance J:338019
thick interventricular septum J:338019
thick ventricular wall J:338019
thin myocardium compact layer J:338019
ventricular septal defect J:338019
Chd4Gt(RRO120)Byg/Chd4Gt(RRO120)Byg
B6.129P2-Chd4Gt(RRO120)Byg 		abnormal extraembryonic tissue physiology J:224146
absent blastocoele J:224146
embryonic lethality before implantation, complete penetrance J:224146
increased apoptosis J:224146
Chd4tm1.1Kge/Chd4tm1.1Kge
Tg(Lck-cre)1Cwi/0
involves: C57BL/6 * SJL 		abnormal CD4-positive, alpha beta T cell morphology J:109547
abnormal T cell physiology J:109547
arrested T cell differentiation J:109547
decreased double-positive T cell number J:109547
increased CD8-positive, alpha-beta T cell number J:109547
lymph node hypoplasia J:109547
spleen hypoplasia J:109547
Chd4tm1.1Kge/Chd4tm1.2Kge
Tg(Lck-cre)1Cwi/0
involves: C57BL/6 * SJL 		thymus hypoplasia J:109547
Chd4tm1.2Bh/Chd4tm1.2Bh
involves: 129P2/OlaHsd * C57BL/6 * CBA 		embryonic lethality, complete penetrance J:224146
Chd4tm1.2Kge/Chd4tm1.2Kge
Tg(Lck-cre)1Cwi/0
involves: C57BL/6 * DBA/2 * SJL 		abnormal cell cycle J:109547
abnormal T cell differentiation J:109547
decreased double-positive T cell number J:109547
decreased T cell proliferation J:109547
increased CD8-positive, alpha-beta T cell number J:109547
increased double-negative T cell number J:109547
thymus hypoplasia J:109547
Chd4tm1b(EUCOMM)Wtsi/Chd4tm1b(EUCOMM)Wtsi
C57BL/6N-Chd4tm1b(EUCOMM)Wtsi/Bay 		embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory