Agr2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Agr2
anterior gradient 2
MGI:1344405

33 phenotypes from 7 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Agr2^{tm1(KOMP)Vlcg}/Agr2^{tm1(KOMP)Vlcg} C57BL/6-Agr2^{tm1(KOMP)Vlcg}	abnormal digestive system morphology	J:220492
	decreased body weight	J:220492
	preweaning lethality, incomplete penetrance	J:220492
Agr2^tm1.1Lex/Agr2^tm1.1Lex involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6	abnormal female reproductive system physiology	J:195573
	abnormal gastric chief cell morphology	J:195573
	abnormal gastric parietal cell morphology	J:195573
	abnormal intestine physiology	J:195573
	abnormal large intestine morphology	J:195573
	abnormal small intestine morphology	J:195573
	abnormal stomach enteroendocrine cell morphology	J:195573
	abnormal stomach glandular epithelium morphology	J:195573
	anemia	J:195573
	decreased body weight	J:195573
	decreased circulating serum albumin level	J:195573
	decreased total fat pad weight	J:195573
	enlarged stomach	J:195573
	increased cell proliferation	J:195573
	intestinal obstruction	J:195573
	premature death	J:195573
	stomach mucosa hyperplasia	J:195573
Agr2^tm1.1Lpkn/Agr2^tm1.1Lpkn Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ involves: 129 * 129S6/SvEvTac * C57BL/6	abnormal enterocyte morphology	J:156704
	abnormal enterocyte proliferation	J:156704
	abnormal intestinal goblet cell morphology	J:156704
	colitis	J:156704
	increased enterocyte apoptosis	J:156704
	increased Paneth cell number	J:156704
Agr2^tm1.2Erle/Agr2^tm1.2Erle involves: 129S4/SvJae * FVB/N	abnormal intestinal mucosa morphology	J:148339
	increased mast cell number	J:148339
	increased susceptibility to induced colitis	J:148339
	rectal prolapse	J:148339
Agr2^tm1.2Lpkn/Agr2^tm1.2Lpkn involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	abnormal enterocyte morphology	J:156704
	abnormal intestinal goblet cell morphology	J:156704
	abnormal large intestine crypts of Lieberkuhn morphology	J:156704
	abnormal Peyer's patch follicle morphology	J:156704
	colitis	J:156704
	ileum inflammation	J:156704
	increased Paneth cell number	J:156704
Agr2^tm1Lex/Agr2^tm1Lex Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6	increased cell proliferation	J:195573
Tg(SFTPC-Agr2)#Eem/0 involves: FVB/N	abnormal respiratory system development	J:185603

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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