Zeb2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Zeb2
zinc finger E-box binding homeobox 2
MGI:1344407

28 phenotypes from 3 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}/Gt(ROSA)26Sor^{tm18(Zeb2)Jhai} Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * CD-1 * DBA/2	increased T cell acute lymphoblastic leukemia incidence	J:263520
	premature death	J:263520
Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}/Gt(ROSA)26Sor^{tm18(Zeb2)Jhai} Tg(Tek-cre)1Ywa/0 involves: C57BL/6 * CD-1 * SJL	increased T cell acute lymphoblastic leukemia incidence	J:263520
	increased thymus tumor incidence	J:263520
	premature death	J:263520
Zeb2^tm1.1Yhi/Zeb2^tm1.1Yhi Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * DBA/2	abnormal hair follicle bulge morphology	J:211299
	abnormal hair follicle melanocyte morphology	J:211299
	abnormal melanoblast migration	J:211299
	abnormal melanoblast morphology	J:211299
	abnormal melanosome morphology	J:211299
	absent hair follicle melanin granules	J:211299
	reduced hair shaft melanin granule number	J:211299
Zeb2^tm1.1Yhi/Zeb2^tm1.1Yhi Tg(Pax6-cre)1Knd/0 involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6	abnormal lens fiber morphology	J:101730
	abnormal lens morphology	J:101730
	small lens	J:101730
Zeb2^tm1.1Yhi/Zeb2^tm1.1Yhi Tg(Pax6-cre,GFP)1Pgr/0 involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * FVB	abnormal lens fiber morphology	J:101730
	abnormal lens morphology	J:101730
	small lens	J:101730
Zeb2^tm1.1Yhi/Zeb2^tm1.1Yhi Tg(Tyr-cre)1Lru/Y involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	hypopigmentation	J:211299
	reduced hair shaft melanin granule number	J:211299
Zeb2^tm1.2Yhi/Zeb2⁺ involves: 129S1/Sv * 129X1/SvJ * CD-1	normal nervous system phenotype	J:82084
Zeb2^tm1.2Yhi/Zeb2^tm1.2Yhi involves: 129S1/Sv * 129X1/SvJ	embryonic lethality during organogenesis, complete penetrance	J:75138
Zeb2^tm1.2Yhi/Zeb2^tm1.2Yhi involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal cranial neural crest cell migration	J:82084
	abnormal neural crest cell delamination	J:82084
	abnormal neural plate morphology	J:82084
	absent first pharyngeal arch	J:82084
	absent vagal neural crest cells	J:82084
	embryonic growth arrest	J:82084
	embryonic lethality during organogenesis, complete penetrance	J:82084
	incomplete embryo turning	J:82084
	open neural tube	J:82084
Zeb2^tm1.2Yhi/Zeb2^tm1.2Yhi involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal embryo development	J:75138
	embryonic lethality during organogenesis, complete penetrance	J:75138
Zeb2^tm1.2Yhi/Zeb2^tm1.2Yhi involves: 129S1/Sv * 129X1/SvJ * ICR	abnormal neural plate morphology	J:108819
	abnormal somite development	J:101031, J:108819
	abnormal somite shape	J:101031
	decreased somite size	J:101031, J:108819
	open neural tube	J:108819

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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