About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Spry2
sprouty RTK signaling antagonist 2
MGI:1345138
64 phenotypes from 4 alleles in 5 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Mesp1tm2(cre)Ysa/Mesp1+
Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
involves: C57BL/6NCrlj * CBA/JNCrlj 		abnormal cardiac epithelial to mesenchymal transition J:143444
abnormal cardiac outflow tract development J:143444
abnormal heart development J:143444
abnormal heart morphology J:143444
atrioventricular septal defect J:143444
bicuspid aortic valve J:143444
double outlet right ventricle J:143444
persistent truncus arteriosus J:143444
ventricular septal defect J:143444
Pax3tm1(cre)Joe/Pax3+
Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Not Specified 		normal cardiovascular system phenotype J:143444
short mandible J:143444
short snout J:143444
Spry2tm1.1Mrt/Spry2tm1.1Mrt
involves: 129/Sv * 129P2/OlaHsd * Black Swiss * C57BL/6 * FVB/N 		abnormal auditory brainstem response waveform shape J:98303
abnormal Claudius cell morphology J:98303
abnormal digestive system physiology J:98303
abnormal organ of Corti morphology J:98303
abnormal organ of Corti supporting cell morphology J:98303
abnormal pillar cell morphology J:98303
decreased body size J:98303
increased cochlear outer hair cell number J:98303
increased Deiters cell number J:98303
increased or absent threshold for auditory brainstem response J:98303
postnatal lethality, incomplete penetrance J:98303
Spry2tm1.1Mrt/Spry2tm1.1Mrt
involves: 129P2/OlaHsd 		abnormal chondrocyte morphology J:315670
abnormal craniofacial bone morphology J:315670
abnormal diastema morphology J:119280
abnormal mandible morphology J:315670
abnormal mandibular condyloid process morphology J:315670
abnormal mandibular coronoid process morphology J:315670
abnormal maxillary shelf morphology J:315670
abnormal molar cusp morphology J:119280
abnormal neurocranium morphology J:315670
abnormal primary cilium morphology J:315670
abnormal temporal bone morphology J:315670
abnormal tooth development J:119280
abnormal tooth morphology J:315670
abnormal vertebral arch morphology J:315670
abnormal vertebral spinous process morphology J:315670
abnormal vertebral transverse process morphology J:315670
cleft palate J:315670
complete cleft palate J:315670
decreased bone mineral density J:315670
decreased length of long bones J:315670
decreased trabecular bone mass J:315670
enlarged frontal bone J:315670
enlarged interparietal bone J:315670
increased cranium height J:315670
increased long bone epiphyseal plate size J:315670
malocclusion J:315670
short nasal bone J:315670
short snout J:315670
small neurocranium J:315670
small supraoccipital bone J:315670
small vertebral body J:315670
spinal stenosis J:315670
supernumerary teeth J:119280, J:315670
wide intermaxillary suture J:315670
Spry2tm1Ayos/Spry2tm1Ayos
B6.Cg-Spry2tm1Ayos 		abnormal digestive system physiology J:99827
abnormal enteric ganglia morphology J:99827
abnormal enteric nervous system morphology J:99827
abnormal enteric neuron morphology J:99827
abnormal intestine morphology J:99827
decreased body size J:99827
dilated esophagus J:99827
intestinal obstruction J:99827
premature death J:99827
Spry2tm1Mrt/Spry2tm1Mrt
involves: 129P2/OlaHsd 		increased lung tumor incidence J:119477
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory