About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Spry2
sprouty RTK signaling antagonist 2
MGI:1345138
31 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Ednrbs-36Pub/Ednrb+
Spry2tm1.1Mrt/Spry2+
involves: 101/Rl * 129P2/OlaHsd * C3H/Rl * C57BL/6J 		abnormal palatal rugae morphology J:125229
cleft secondary palate J:125229
Ednrbs-36Pub/Ednrbs-36Pub
Tg(Spry2)2Tpo/0
B6.Cg-Ednrbs-36Pub Tg(Spry2)2Tpo 		abnormal palate bone morphology J:125229
cleft secondary palate J:125229
normal craniofacial phenotype J:125229
maxillary shelf hypoplasia J:125229
Ednrbs-36Pub/Ednrbs-36Pub
Tg(Spry2)69Tpo/0
B6.Cg-Ednrbs-36Pub Tg(Spry2)69Tpo 		abnormal palate bone morphology J:125229
cleft secondary palate J:125229
normal craniofacial phenotype J:125229
maxillary shelf hypoplasia J:125229
Fgfr1tm1.1Jpa/Fgfr1+
Spry2tm1.1Mrt/Spry2tm1.1Mrt
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		supernumerary teeth J:119280
Fgfr2tm1.1Dor/Fgfr2+
Spry2tm1.1Mrt/Spry2tm1.1Mrt
involves: 129P2/OlaHsd * 129X1/SvJ 		normal craniofacial phenotype J:119280
Krastm4.1Tyj/Kras+
Spry2tm1Mrt/Spry2tm1Mrt
involves: 129P2/OlaHsd 		increased lung tumor incidence J:119477
Krastm4Tyj/Kras+
Spry2tm1.1Mrt/Spry2tm1.1Mrt
Meox2tm1(cre)Sor/Meox2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N 		impaired branching involved in bronchus morphogenesis J:119477
Ptentm2.1Ppp/Pten+
Spry1tm1Jdli/Spry1tm1.1Jdli
Spry2tm1Mrt/Spry2tm1.1Mrt
Tg(Osr1-cre)4Mrt/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N 		increased prostate gland tumor incidence J:192348
increased prostate intraepithelial neoplasia incidence J:192348
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Tg(Osr1-cre)4Mrt/0
involves: 129P2/OlaHsd * 129S1/Sv * FVB/N 		increased prostate intraepithelial neoplasia incidence J:192348
Spry1tm1Jdli/Spry1tm1.1Jdli
Spry2tm1Mrt/Spry2tm1.1Mrt
Tg(Osr1-cre)4Mrt/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N 		increased prostate intraepithelial neoplasia incidence J:192348
prostate gland epithelial hyperplasia J:192348
Spry2tm1.1Mrt/Spry2+
Spry4tm1.2Mrt/Spry4tm1.2Mrt
involves: 129P2/OlaHsd 		abnormal autopod morphology J:315670
abnormal chondrocyte morphology J:315670
abnormal primary cilium morphology J:315670
abnormal skeleton morphology J:315670
increased enchondroma incidence J:315670
increased osteochondroma incidence J:315670
short tibia J:315670
Spry2tm1.1Mrt/Spry2tm1.1Mrt
Spry4tm1.2Mrt/Spry4+
involves: 129P2/OlaHsd 		abnormal autopod morphology J:315670
abnormal skeleton morphology J:315670
increased enchondroma incidence J:315670
increased osteochondroma incidence J:315670
Spry2tm1Ayos/Spry2+
Spry4tm1Ayos/Spry4tm1Ayos
involves: 129 * C57BL/6J 		decreased body weight J:116506
perinatal lethality, incomplete penetrance J:116506
postnatal lethality, incomplete penetrance J:116506
Spry2tm1Ayos/Spry2tm1Ayos
Spry4tm1Ayos/Spry4+
involves: 129 * C57BL/6J 		prenatal lethality, complete penetrance J:116506
Spry2tm1Ayos/Spry2tm1Ayos
Spry4tm1Ayos/Spry4tm1Ayos
involves: 129 * C57BL/6J 		abnormal brain development J:116506
abnormal craniofacial morphology J:116506
abnormal forebrain development J:116506
abnormal limb morphology J:116506
abnormal lung development J:116506
abnormal respiratory conducting tube morphology J:116506
alobar holoprosencephaly J:116506
cyclopia J:116506
embryonic lethality during organogenesis, incomplete penetrance J:116506
prenatal lethality, complete penetrance J:116506
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory