Pde10a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pde10a
phosphodiesterase 10A
MGI:1345143

29 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pde10a^em1(IMPC)H/Pde10a^em1(IMPC)H C57BL/6NTac-Pde10a^em1(IMPC)H/H	decreased locomotor activity	J:211773
	increased circulating iron level	J:211773
	increased mean corpuscular volume	J:211773
	increased mean platelet volume	J:211773
Pde10a^tm1(tTA)Yoko/Pde10a^tm1(tTA)Yoko involves: 129S/SvEv	abnormal social investigation	J:135447
Pde10a^tm1.1Njbr/Pde10a^tm1.1Njbr involves: C57BL/6	abnormal motor coordination/balance	J:231965
	bradykinesia	J:231965
	decreased vertical activity	J:231965
	impaired balance	J:231965
	impaired coordination	J:231965
Pde10a^tm1Dgen/Pde10a^tm1Dgen involves: C57BL/6J	abnormal action potential	J:216851
	abnormal latent inhibition of conditioning behavior	J:216851
	impaired conditioning behavior	J:216851
Pde10a^tm1Pfi/Pde10a^tm1Pfi DBA/1LacJ-Pde10a^tm1Pfi	abnormal avoidance learning behavior	J:111662
	abnormal enzyme/coenzyme activity	J:111662
	decreased body weight	J:111662
	decreased exploration in new environment	J:111662
	decreased locomotor activity	J:111662
Pde10a^tm1Smsh/Pde10a^tm1Smsh B6NTac.Cg-Pde10a^tm1Smsh	abnormal circulating glucose level	J:209032
	abnormal circulating insulin level	J:209032
	decreased body weight	J:209032
	decreased circulating alanine transaminase level	J:209032
	decreased circulating cholesterol level	J:209032
	decreased circulating insulin level	J:209032
	decreased circulating leptin level	J:209032
	decreased food intake	J:209032
	decreased lean body mass	J:209032
	decreased respiratory quotient	J:209032
	decreased susceptibility to diet-induced obesity	J:209032
	decreased total fat pad weight	J:209032
	increased insulin sensitivity	J:209032

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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