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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Spry4
sprouty RTK signaling antagonist 4
MGI:1345144
20 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Spry2tm1.1Mrt/Spry2+
Spry4tm1.2Mrt/Spry4tm1.2Mrt
involves: 129P2/OlaHsd 		abnormal autopod morphology J:315670
abnormal chondrocyte morphology J:315670
abnormal primary cilium morphology J:315670
abnormal skeleton morphology J:315670
increased enchondroma incidence J:315670
increased osteochondroma incidence J:315670
short tibia J:315670
Spry2tm1.1Mrt/Spry2tm1.1Mrt
Spry4tm1.2Mrt/Spry4+
involves: 129P2/OlaHsd 		abnormal autopod morphology J:315670
abnormal skeleton morphology J:315670
increased enchondroma incidence J:315670
increased osteochondroma incidence J:315670
Spry2tm1Ayos/Spry2+
Spry4tm1Ayos/Spry4tm1Ayos
involves: 129 * C57BL/6J 		decreased body weight J:116506
perinatal lethality, incomplete penetrance J:116506
postnatal lethality, incomplete penetrance J:116506
Spry2tm1Ayos/Spry2tm1Ayos
Spry4tm1Ayos/Spry4+
involves: 129 * C57BL/6J 		prenatal lethality, complete penetrance J:116506
Spry2tm1Ayos/Spry2tm1Ayos
Spry4tm1Ayos/Spry4tm1Ayos
involves: 129 * C57BL/6J 		abnormal brain development J:116506
abnormal craniofacial morphology J:116506
abnormal forebrain development J:116506
abnormal limb morphology J:116506
abnormal lung development J:116506
abnormal respiratory conducting tube morphology J:116506
alobar holoprosencephaly J:116506
cyclopia J:116506
embryonic lethality during organogenesis, incomplete penetrance J:116506
prenatal lethality, complete penetrance J:116506
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory