Akt3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Akt3
thymoma viral proto-oncogene 3
MGI:1345147

21 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Akt3^Nmf350/Akt3⁺ C57BL/6J-Akt3^Nmf350	abnormal seizure response to electrical stimulation	J:169028
	increased brain size	J:169028
	increased brain weight	J:169028
	increased susceptibility to pharmacologically induced seizures	J:169028
	maximal tonic hindlimb extension seizures	J:169028
	sporadic seizures	J:169028
	tonic-clonic seizures	J:169028
Akt3^Nmf350/Akt3^Nmf350 C57BL/6J-Akt3^Nmf350	abnormal neuron morphology	J:169028
	abnormal seizure response to electrical stimulation	J:169028
	absent corpus callosum	J:169028
	ectopic cerebellar granule cells	J:169028
	enlarged hippocampus	J:169028
	increased brain size	J:169028
	increased brain weight	J:169028
	increased susceptibility to pharmacologically induced seizures	J:169028
	maximal tonic hindlimb extension seizures	J:169028
	tonic-clonic seizures	J:169028
Akt3^tm1Hem/Akt3^tm1Hem involves: 129P2/OlaHsd * C57BL/6	abnormal brain ventricle morphology	J:98804
	decreased brain size	J:98804
	decreased brain weight	J:98804
	decreased corpus callosum size	J:98804
	increased susceptibility to neuronal excitotoxicity	J:98804
Akt3^tm1Mbb/Akt3⁺ B6.Cg-Akt3^tm1Mbb	decreased brain size	J:245549
Akt3^tm1Mbb/Akt3^tm1Mbb B6.Cg-Akt3^tm1Mbb	abnormal spatial reference memory	J:245549
	decreased brain size	J:245549
	impaired discrimination learning	J:245549
	increased locomotor activity	J:245549
Akt3^tm1Mbb/Akt3^tm1Mbb involves: C57BL/6J	abnormal seizure response to electrical stimulation	J:169028
	maximal tonic hindlimb extension seizures	J:169028
	tonic-clonic seizures	J:169028
Akt3^tm1Mbb/Akt3^tm1Mbb Not Specified	decreased brain size	J:96823
	normal homeostasis/metabolism phenotype	J:96823
	normal immune system phenotype	J:135903

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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