Slc11a1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc11a1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
MGI:1345275

10 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Slc11a1^r/Slc11a1^r involves: 129S2/SvPas	increased susceptibility to bacterial infection	J:124378
	increased susceptibility to induced morbidity/mortality	J:124378
Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Slc11a1^s/Slc11a1^s B6.129S2-Casp1^tm1Flv	cecum inflammation	J:124378
	increased susceptibility to bacterial infection	J:124378
	increased susceptibility to induced morbidity/mortality	J:124378
Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del Slc11a1^r/Slc11a1^s involves: 129/Sv * 129S2/SvPas * C57BL/6	increased susceptibility to bacterial infection	J:112400
Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del Slc11a1^s/Slc11a1^s B6.129S2-Casp1^tm1Sesh Casp4^del	abnormal macrophage physiology	J:112400
	increased susceptibility to bacterial infection	J:112400
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r BXH2/TyJ	abnormal myelopoiesis	J:97931
	decreased interferon-gamma secretion	J:97931
	decreased interleukin-12 secretion	J:97931
	enlarged spleen	J:97931
	increased chronic myelocytic leukemia incidence	J:97931
	increased susceptibility to bacterial infection	J:97931
	premature death	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r involves: A/J * BXH2/TyJ	increased chronic myelocytic leukemia incidence	J:97931
	premature death	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r involves: BALB/cJ * BXH2/TyJ	increased susceptibility to bacterial infection	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r involves: BXH2/TyJ * C3H/HeJ	enlarged spleen	J:97931
	increased susceptibility to bacterial infection	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r involves: BXH2/TyJ * C57BL/6J	increased susceptibility to bacterial infection	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s involves: BALB/cJ * BXH2/TyJ	increased susceptibility to bacterial infection	J:97931
Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s involves: BXH2/TyJ * C57BL/6J	increased susceptibility to bacterial infection	J:97931
Irf8^myls/Irf8^myls Slc11a1^s/Slc11a1^s involves: BALB/cJ * BXH2/TyJ	increased susceptibility to bacterial infection	J:97931
Nlrc4^tm1Gln/Nlrc4^tm1Gln Slc11a1^s/Slc11a1^s B6.129S5-Nlrc4^tm1Gln	increased susceptibility to bacterial infection	J:124378
Nlrp3^tm1Flv/Nlrp3^tm1Flv Slc11a1^s/Slc11a1^s B6.129S5-Nlrp3^tm1Flv	increased susceptibility to bacterial infection	J:124378
	increased susceptibility to induced morbidity/mortality	J:124378
Pycard^tm1Flv/Pycard^tm1Flv Slc11a1^s/Slc11a1^s B6.129S5-Pycard^tm1Flv	increased susceptibility to bacterial infection	J:124378

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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