Slc11a2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
MGI:1345279

45 phenotypes from 3 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Slc11a2^mk/Slc11a2^mk 129S6.MK-Slc11a2^mk	increased liver iron level	J:98088
Slc11a2^mk/Slc11a2^mk 129S6.MK-Slc11a2^mk	normal mortality/aging	J:98088
Slc11a2^mk/Slc11a2^mk involves: C57BL/6J * DBA/2J * WB/Re	increased erythrocyte protoporphyrin level	J:5985
Slc11a2^mk/Slc11a2^mk MK/ReJ	abnormal iron homeostasis	J:100202
	anisocytosis	J:162917
	decreased body weight	J:5167
	decreased cellular hemoglobin content	J:5167
	decreased hematocrit	J:5167
	decreased hemoglobin content	J:5167, J:162917
	decreased mean corpuscular hemoglobin	J:5167
	hemolysis	J:162917
	high mean erythrocyte cell number	J:5167
	hypochromic microcytic anemia	J:5167, J:162917
	increased erythrocyte clearance	J:162917
	increased spleen weight	J:5167
	normal liver/biliary system phenotype	J:5167
	maternal effect	J:5167
	microcytosis	J:5167
	postnatal lethality, incomplete penetrance	J:5167, J:98088
	reduced female fertility	J:5167
	reticulocytosis	J:5167, J:162917
	skin lesions	J:5167
Slc11a2^mk/Slc11a2^mk SEC.Cg-Slc11a2^mk	anisocytosis	J:162917
	decreased body weight	J:5167
	decreased cellular hemoglobin content	J:5167
	decreased erythrocyte osmotic fragility	J:5167
	decreased hematocrit	J:5167
	decreased hemoglobin content	J:5167, J:162917
	decreased mean corpuscular hemoglobin	J:5167
	hemolysis	J:162917
	high mean erythrocyte cell number	J:5167
	hypochromic microcytic anemia	J:5167, J:162917
	increased erythrocyte clearance	J:162917
	increased spleen weight	J:5167
	normal liver/biliary system phenotype	J:5167
	maternal effect	J:5167
	microcytosis	J:5167
	postnatal lethality	J:5167
	reduced female fertility	J:5167
	reticulocytosis	J:5167, J:162917
	skin lesions	J:5167
Slc11a2^tm1Nca/Slc11a2⁺ involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2^tm1Nca	decreased liver iron level	J:98088
Slc11a2^tm1Nca/Slc11a2^tm1Nca 129S6.129S4-Slc11a2^tm1Nca	abnormal erythrocyte morphology	J:98088
	anisocytosis	J:98088
	decreased erythrocyte cell number	J:98088
	decreased hematocrit	J:98088
	decreased hemoglobin content	J:98088
	decreased mean corpuscular hemoglobin concentration	J:98088
	decreased mean corpuscular volume	J:98088
	normal homeostasis/metabolism phenotype	J:98088
	microcytic anemia	J:98088
	pallor	J:98088
	poikilocytosis	J:98088
	postnatal growth retardation	J:98088
	postnatal lethality, complete penetrance	J:98088
Slc11a2^tm2Nca/Slc11a2^tm2Nca Tg(Vil1-cre)20Syr/? involves: 129S6.129S4-Slc11a2^tm2Nca * C57BL/6 * DBA/2	abnormal erythrocyte morphology	J:98088
	abnormal spleen morphology	J:98088
	anemia	J:98088
	decreased brain iron level	J:98088
	decreased heart iron level	J:98088
	decreased kidney iron level	J:98088
	decreased liver iron level	J:98088
	decreased spleen iron level	J:98088
	enlarged heart	J:98088
	enlarged spleen	J:98088
	extramedullary hematopoiesis	J:98088
	increased spleen red pulp amount	J:98088

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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