Sufu Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sufu
SUFU negative regulator of hedgehog signaling
MGI:1345643

69 phenotypes from 9 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sufu^b2b273Clo/Sufu^b2b273Clo C57BL/6J-Sufu^b2b273Clo	abnormal coronary artery morphology	J:175213
	abnormal head shape	J:175213
	cleft palate	J:175213
	coronary fistula	J:175213
	double outlet right ventricle	J:175213
	microcephaly	J:175213
	micrognathia	J:175213
	muscular ventricular septal defect	J:175213
	overriding aortic valve	J:175213
	perimembraneous ventricular septal defect	J:175213
Sufu^Gt(XB699)Byg/Sufu^Gt(XB699)Byg involves: 129P2/OlaHsd * C57BL/6	abnormal heart morphology	J:125534
	abnormal neural tube closure	J:125534
	embryonic lethality during organogenesis, complete penetrance	J:125534
Sufu^rgsc2062/Sufu^rgsc2062 either: B6JJcl(C3JJcl)-Sufu^rgsc2062 or B6JJcl(D2JJcl)-Sufu^rgsc2062	abnormal craniofacial morphology	J:228335
	abnormal limb morphology	J:228335
	edema	J:228335
	exencephaly	J:228335
	hemorrhage	J:228335
	lethality throughout fetal growth and development, complete penetrance	J:228335
	polydactyly	J:228335
	small lung	J:228335
Sufu^rgsc2075/Sufu^rgsc2075 either: B6JJcl(C3JJcl)-Sufu^rgsc2075 or B6JJcl(D2JJcl)-Sufu^rgsc2075	embryonic lethality during organogenesis, complete penetrance	J:228335
	exencephaly	J:228335
	failure of initiation of embryo turning	J:228335
Sufu^tm1.1Blnw/Sufu^tm1.1Blnw involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N	abnormal neural tube morphology	J:161408
	embryonic lethality during organogenesis, complete penetrance	J:161408
Sufu^tm1Aeb/Sufu⁺ either: 129S1/Sv-Sufu^tm1Aeb or (involves: 129S1/Sv * C57BL/6)	no abnormal phenotype detected	J:101731
Sufu^tm1Aeb/Sufu^tm1Aeb either: 129S1/Sv-Sufu^tm1Aeb or (involves: 129S1/Sv * C57BL/6)	abnormal developmental patterning	J:101731
	abnormal direction of heart looping	J:101731
	abnormal dorsal-ventral axis patterning	J:101731
	abnormal left-right axis patterning	J:101731
	abnormal myocardium layer morphology	J:101731
	abnormal primitive node morphology	J:101731
	abnormal somite development	J:101731
	brain aneurysm	J:101731
	descending aorta dilation	J:101731
	embryonic growth retardation	J:101731
	embryonic lethality during organogenesis, complete penetrance	J:101731
	incomplete embryo turning	J:101731
	intracranial hemorrhage	J:101731
	open neural tube	J:101731
Sufu^{tm1b(KOMP)Wtsi}/Sufu⁺ C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd	abnormal stomach morphology	J:211773
	cardiovascular system phenotype	J:211773
	decreased total body fat amount	J:211773
	enlarged lymph nodes	J:211773
	increased startle reflex	J:211773
Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd	abnormal embryo size	J:211773
	abnormal eye morphology	J:211773
	abnormal forebrain development	J:211773
	abnormal hindbrain development	J:211773
	abnormal limb bud morphology	J:211773
	abnormal liver size	J:211773
	abnormal midbrain development	J:211773
	abnormal neural tube closure	J:211773
	abnormal placenta size	J:211773
	embryonic growth retardation	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	pale liver	J:211773
	pale yolk sac	J:211773
	pallor	J:211773
	preweaning lethality, complete penetrance	J:211773
Sufu^tm1Hui/Sufu^tm1Hui Tg(Fabp4-cre)1Rev/0 involves: C57BL/6	abnormal white adipose tissue morphology	J:166285
	abnormal white adipose tissue physiology	J:166285
	abnormal white fat cell morphology	J:166285
	normal adipose tissue phenotype	J:166285
	decreased subcutaneous adipose tissue amount	J:166285
	decreased white adipose tissue amount	J:166285
	decreased white fat cell number	J:166285
	decreased white fat cell size	J:166285
	normal homeostasis/metabolism phenotype	J:166285
Sufu^tm1Rto/Sufu⁺ involves: 129X1/SvJ * C57BL/6	abnormal coat/hair pigmentation	J:105832
	abnormal epidermis stratum basale morphology	J:105832
	abnormal skin appearance	J:105832
	alopecia	J:105832
Sufu^tm1Rto/Sufu^tm1Rto involves: 129X1/SvJ * C57BL/6	abnormal floor plate morphology	J:105832
	abnormal forebrain development	J:105832
	abnormal hindbrain development	J:105832
	abnormal midbrain development	J:105832
	abnormal neural tube morphology	J:105832
	embryonic lethality during organogenesis, complete penetrance	J:105832
	open neural tube	J:105832

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