Coro1a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Coro1a
coronin, actin binding protein 1A
MGI:1345961

31 phenotypes from 7 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Coro1a^koy/Coro1a^koy C57BL/6-Coro1a^koy	abnormal T cell physiology	J:141431
	decreased CD4-positive, alpha-beta T cell number	J:141431
	decreased CD8-positive, alpha-beta T cell number	J:141431
	decreased thymocyte number	J:141431
Coro1a^{Lmb3-C57BL/6Scr}/Coro1a^{Lmb3-C57BL/6Scr} MRL.Cg-Coro1a^C57BL/6Scr Fas^lpr	decreased autoantibody level	J:125557
	decreased spleen weight	J:125557
	decreased susceptibility to systemic lupus erythematosus	J:125557
	glomerulonephritis	J:125557
	small lymph nodes	J:125557
Coro1a^{Lmb3-MRL/MpScr}/Coro1a^{Lmb3-MRL/MpScr} B6.MRL-Coro1a^MRL/MpScr Fas^lpr	enlarged lymph nodes	J:125557
	increased spleen weight	J:125557
	increased susceptibility to systemic lupus erythematosus	J:125557
Coro1a^{Lmb3-MRL/MpScr}/Coro1a^{Lmb3-MRL/MpScr} involves: C57BL/6-Fas^lpr * MRL-Fas^lpr	enlarged lymph nodes	J:45708
	enlarged spleen	J:45708
Coro1a^ptcd/Coro1a^ptcd B6.CTS-Coro1a^ptcd	abnormal effector T cell morphology	J:141431
	abnormal T cell activation	J:141431
	abnormal T cell physiology	J:141431
	decreased CD4-positive, alpha-beta T cell number	J:141431
	decreased CD8-positive, alpha-beta T cell number	J:141431
	increased T cell apoptosis	J:141431
	increased thymocyte number	J:141431
Coro1a^ptcd/Coro1a^tm1Achn B6.Cg-Coro1a^ptcd Coro1a^tm1Achn	abnormal effector T cell morphology	J:141431
	abnormal T cell activation	J:141431
	abnormal T cell physiology	J:141431
	decreased CD4-positive, alpha-beta T cell number	J:141431
	decreased CD8-positive, alpha-beta T cell number	J:141431
	increased thymocyte number	J:141431
Coro1a^{tm1.1(KOMP)Vlcg}/Coro1a^{tm1.1(KOMP)Vlcg} C57BL/6N-Coro1a^{tm1.1(KOMP)Vlcg}/Ucd	hyperactivity	J:211773
Coro1a^tm1Achn/Coro1a^tm1Achn B6.129X1-Coro1a^tm1Achn	decreased thymocyte number	J:141431
Coro1a^tm1Achn/Coro1a^tm1Achn B6.129X1-Coro1a^tm1Achn	increased T cell apoptosis	J:141431
Coro1a^tm1Achn/Coro1a^tm1Achn involves: 129X1/SvJ	decreased interleukin-6 secretion	J:177785
	decreased tumor necrosis factor secretion	J:177785
	increased mast cell degranulation	J:177785
Coro1a^tm1Achn/Coro1a^tm1Achn involves: 129X1/SvJ * C57BL/6	abnormal leukocyte migration	J:111593
	decreased CD4-positive, alpha-beta T cell number	J:111593
	decreased CD8-positive, alpha-beta T cell number	J:111593
	decreased memory T cell number	J:111593
	decreased T cell number	J:111593
Coro1a^tm1Jpie/Coro1a^tm1Jpie involves: 129 * C57BL/6	abnormal T cell activation	J:133258
	abnormal thymocyte activation	J:133258
	decreased B cell number	J:133258
	decreased CD4-positive, alpha-beta T cell number	J:133258
	decreased CD8-positive, alpha-beta T cell number	J:133258
	decreased interleukin-2 secretion	J:133258
	decreased monocyte cell number	J:133258
	decreased susceptibility to bacterial infection	J:133404
	decreased T cell proliferation	J:133258
	impaired macrophage phagocytosis	J:133404

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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