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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Slc26a4
solute carrier family 26, member 4
MGI:1346029
93 phenotypes from 9 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Slc26a4em1Jgao/Slc26a4em1Jgao
involves: CBA/CaJ 		abnormal cochlear hair cell stereociliary bundle morphology J:291230
abnormal stria vascularis morphology J:291230
circling J:291230
cochlear hair cell degeneration J:291230
decreased body weight J:291230
detached otolithic membrane J:291230
enlarged otoliths J:291230
fused inner hair cell stereocilia J:291230
impaired balance J:291230
impaired hearing J:291230
increased or absent threshold for auditory brainstem response J:291230
torticollis J:291230
Slc26a4loop/Slc26a4loop
C3HeB/FeJ-Slc26a4loop 		abnormal cochlea morphology J:216847
abnormal cochlear hair cell stereociliary bundle morphology J:216847
abnormal cochlear sensory epithelium morphology J:216847
abnormal inner ear morphology J:216847
abnormal tectorial membrane morphology J:216847
abnormal thyroid follicle morphology J:216847
abnormal thyroid gland morphology J:216847
cochlear hair cell degeneration J:216847
cochlear inner hair cell degeneration J:216847
cochlear outer hair cell degeneration J:216847
dilated endolymphatic duct J:216847
enlarged tectorial membrane J:216847
Slc26a4loop/Slc26a4loop
involves: C3HeB/FeJ 		abnormal crista ampullaris morphology J:163655
abnormal gait J:163655
abnormal inner ear vestibule morphology J:163655
abnormal otolithic membrane morphology J:163655
abnormal semicircular canal morphology J:163655
abnormal utricle morphology J:163655
abnormal vestibular saccule morphology J:163655
abnormal vestibular system physiology J:163655
absent otoliths J:163655
absent pinna reflex J:163655
circling J:163655
deafness J:163655
increased or absent threshold for auditory brainstem response J:163655
Slc26a4m1Btlr/Slc26a4m1Btlr
C57BL/6J-Slc26a4m1Btlr 		abnormal vestibular system physiology J:234260
Slc26a4m2Btlr/Slc26a4m2Btlr
C57BL/6J-Slc26a4m2Btlr 		bidirectional circling J:236690
head tossing J:236690
increased susceptibility to induced colitis J:236690
Slc26a4pdsm/Slc26a4pdsm
BXA7/PgnJ-Slc26a4pdsm/J 		abnormal organ of Corti morphology J:121997
abnormal scala media morphology J:121997
abnormal tectorial membrane morphology J:121997
absent cochlear ganglion J:121997
absent cochlear hair cells J:121997
absent otoliths J:121997
asthenozoospermia J:121997
circling J:121997
deafness J:121997
decreased cochlea coiling J:121997
decreased cochlear hair cell number J:121997
decreased otolith number J:121997
distended Reissner membrane J:121997
normal endocrine/exocrine gland phenotype J:121997
head bobbing J:121997
head tilt J:121997
increased or absent threshold for auditory brainstem response J:121997
oligozoospermia J:121997
normal reproductive system phenotype J:121997
testicular atrophy J:121997
Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
involves: 129S1/Sv * 129X1/SvJ 		abnormal endolymphatic duct morphology J:203206
cochlear hair cell degeneration J:203206
dilated scala media J:203206
stria vascularis degeneration J:203206
Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal behavior J:175861
abnormal hair cell morphology J:175861
abnormal otolith morphology J:175861
abnormal placing response J:175861
abnormal strial marginal cell morphology J:175861
abnormal vestibular aqueduct morphology J:175861
abnormal vestibular system physiology J:175861
circling J:175861
cochlear hair cell degeneration J:175861
cochlear inner hair cell degeneration J:175861
cochlear outer hair cell degeneration J:175861
decreased grip strength J:175861
decreased otolith number J:175861
decreased vestibular hair cell number J:175861
dilated endolymphatic duct J:175861
dilated endolymphatic sac J:175861
dilated scala media J:175861
normal endocrine/exocrine gland phenotype J:175861
enlarged otoliths J:175861
head tilt J:175861
impaired balance J:175861
impaired coordination J:175861
impaired hearing J:175861
impaired swimming J:175861
increased or absent threshold for auditory brainstem response J:175861
normal renal/urinary system phenotype J:175861
stria vascularis degeneration J:175861
vestibular hair cell degeneration J:175861
Slc26a4tm1.1Dontu/Slc26a4tm2.1Dontu
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal endocrine/exocrine gland phenotype J:203206
normal hearing/vestibular/ear phenotype J:203206
normal homeostasis/metabolism phenotype J:203206
normal renal/urinary system phenotype J:203206
Slc26a4tm1Egr/Slc26a4+
involves: 129S6/SvEvTac 		normal hearing/vestibular/ear phenotype J:121442, J:121448
Slc26a4tm1Egr/Slc26a4tm1Egr
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) 		abnormal gait J:67072
abnormal inner ear morphology J:67072
abnormal otolithic membrane morphology J:67072
abnormal semicircular canal morphology J:67072
abnormal vestibular system physiology J:67072
absent otoliths J:67072
absent pinna reflex J:67072
circling J:67072
cochlear inner hair cell degeneration J:67072
cochlear outer hair cell degeneration J:67072
deafness J:67072
dilated cochlea J:67072
dilated endolymphatic duct J:67072
dilated endolymphatic sac J:67072
dilated scala media J:67072
distended Reissner membrane J:67072
enlarged otoliths J:67072
enlarged vestibular saccule J:67072
fused inner hair cell stereocilia J:67072
head bobbing J:67072
head tilt J:67072
impaired coordination J:67072
increased or absent threshold for auditory brainstem response J:67072
sensorineural hearing loss J:67072
utricular macular degeneration J:67072
vestibular saccular macula degeneration J:67072
Slc26a4tm1Egr/Slc26a4tm1Egr
involves: 129S6/SvEvTac 		abnormal calcium ion homeostasis J:121442, J:121448
abnormal cochlear endolymph ionic homeostasis J:121442
abnormal spiral limbus morphology J:101834
abnormal strial basal cell morphology J:101834, J:116301
abnormal strial intermediate cell morphology J:101834, J:116301
abnormal strial marginal cell morphology J:101834, J:116301
abnormal vestibular endolymph ionic homeostasis J:121448
abnormal vestibular endolymph physiology J:121448
absent endocochlear potential J:101834, J:116301
circling J:121448
cochlear hair cell degeneration J:101834
deafness J:121442
decreased endocochlear potential J:121442
dilated cochlea J:116301
dilated endolymphatic duct J:116301
dilated scala media J:101834
distended Reissner membrane J:101834
normal endocrine/exocrine gland phenotype J:67072, J:139883
enlarged otoliths J:101834, J:121448
head tilt J:121448
increased or absent threshold for auditory brainstem response J:121442
nonsyndromic hearing loss J:67072
organ of Corti degeneration J:101834, J:116301
sensorineural hearing loss J:116301
small scala tympani J:116301
stria vascularis degeneration J:101834, J:116301
thin spiral ligament J:101834, J:116301
thin stria vascularis J:116301
type I spiral ligament fibrocyte degeneration J:101834
type II spiral ligament fibrocyte degeneration J:101834
Slc26a4tm1Sole/Slc26a4tm1Sole
involves: 129S/SvEv * C57BL/6 		decreased urine pH J:162257
increased circulating bicarbonate level J:162257
increased urine ammonia level J:162257
Slc26a4tm2.1Dontu/Slc26a4tm2.1Dontu
B6.129-Slc26a4tm2.1Dontu 		normal endocrine/exocrine gland phenotype J:203206
normal hearing/vestibular/ear phenotype J:203206
normal homeostasis/metabolism phenotype J:203206
normal renal/urinary system phenotype J:203206
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory