Gdf15 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gdf15
growth differentiation factor 15
MGI:1346047

32 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gdf15^tm1Breit/Gdf15^tm1Breit B6.Cg-Gdf15^tm1Breit	abnormal basal metabolism	J:197174
	decreased energy expenditure	J:197174
	decreased lean body mass	J:197174
	decreased locomotor activity	J:197174
	normal homeostasis/metabolism phenotype	J:197174
	increased body weight	J:197174
	increased food intake	J:197174
	increased inguinal fat pad weight	J:197174
	increased mesenteric fat pad weight	J:197174
	increased retroperitoneal fat pad weight	J:197174
	increased total body fat amount	J:197174
	increased white adipose tissue amount	J:197174
Gdf15^tm1Kuns/Gdf15^tm1Kuns involves: 129S2/SvPas * C57BL/6	abnormal facial nerve morphology	J:154446
	abnormal L4 dorsal root ganglion morphology	J:154446
	abnormal L5 dorsal root ganglion morphology	J:154446
	abnormal somatic nervous system morphology	J:154446
	abnormal trigeminal nerve morphology	J:154446
	decreased motor neuron number	J:154446
	decreased neuron number	J:154446
	decreased sensory neuron number	J:154446
	impaired coordination	J:154446
	increased body weight	J:154446
Gdf15^tm1Sjl/Gdf15^tm1Sjl involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal kidney morphology	J:202996
	decreased bleeding time	J:195443
	decreased body weight	J:202996
	normal homeostasis/metabolism phenotype	J:61788
	increased fluid intake	J:202996
	increased food intake	J:202996
	increased kidney weight	J:202996
	increased myocardial infarct size	J:118878
	increased platelet aggregation	J:195443
	increased susceptibility to induced morbidity/mortality	J:195443
	increased susceptibility to induced thrombosis	J:195443
	increased urine glucose level	J:202996
	polyuria	J:202996

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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