Gdf15 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gdf15
growth differentiation factor 15
MGI:1346047

32 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gdf15^tm1Breit/Gdf15^tm1Breit B6.Cg-Gdf15^tm1Breit	abnormal basal metabolism	J:197174
	decreased energy expenditure	J:197174
	decreased lean body mass	J:197174
	decreased locomotor activity	J:197174
	normal homeostasis/metabolism phenotype	J:197174
	increased body weight	J:197174
	increased food intake	J:197174
	increased inguinal fat pad weight	J:197174
	increased mesenteric fat pad weight	J:197174
	increased retroperitoneal fat pad weight	J:197174
	increased total body fat amount	J:197174
	increased white adipose tissue amount	J:197174
Gdf15^tm1Kuns/Gdf15^tm1Kuns involves: 129S2/SvPas * C57BL/6	abnormal facial nerve morphology	J:154446
	abnormal L4 dorsal root ganglion morphology	J:154446
	abnormal L5 dorsal root ganglion morphology	J:154446
	abnormal somatic nervous system morphology	J:154446
	abnormal trigeminal nerve morphology	J:154446
	decreased motor neuron number	J:154446
	decreased neuron number	J:154446
	decreased sensory neuron number	J:154446
	impaired coordination	J:154446
	increased body weight	J:154446
Gdf15^tm1Sjl/Gdf15^tm1Sjl involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal kidney morphology	J:202996
	decreased bleeding time	J:195443
	decreased body weight	J:202996
	normal homeostasis/metabolism phenotype	J:61788
	increased fluid intake	J:202996
	increased food intake	J:202996
	increased kidney weight	J:202996
	increased myocardial infarct size	J:118878
	increased platelet aggregation	J:195443
	increased susceptibility to induced morbidity/mortality	J:195443
	increased susceptibility to induced thrombosis	J:195443
	increased urine glucose level	J:202996
	polyuria	J:202996

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24