Nr0b2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nr0b2
nuclear receptor subfamily 0, group B, member 2
MGI:1346344

22 phenotypes from 6 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nr0b2^tm1.1Auw/Nr0b2^tm1.1Auw involves: 129S2/SvPas * C57BL/6J	abnormal testis physiology	J:118368
	decreased testis weight	J:118368
	early sexual maturation	J:118368
	increased circulating testosterone level	J:118368
	increased epididymis weight	J:118368
	small testis	J:118368
Nr0b2^tm1.1Mjev/Nr0b2^tm1.1Mjev involves: 129S/SvEvBrd * 129S4/SvJae	decreased circulating cholesterol level	J:149005
	decreased circulating HDL cholesterol level	J:149005
	decreased circulating LDL cholesterol level	J:149005
	decreased circulating VLDL cholesterol level	J:149005
	normal homeostasis/metabolism phenotype	J:149005
Nr0b2^tm1Auw/Nr0b2^tm1Auw involves: 129S2/SvPas * C57BL/6J	no abnormal phenotype detected	J:118368
Nr0b2^tm1Ddm/Nr0b2^tm1Ddm involves: 129 * C57BL/6	abnormal bile salt homeostasis	J:77065
	abnormal bile salt level	J:77065
	decreased circulating cholesterol level	J:77065
	increased bile salt level	J:77065
	increased liver triglyceride level	J:77065
	increased susceptibility to weight loss	J:77065
Nr0b2^tm1Mjev/Nr0b2^tm1Mjev Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S/SvEvBrd * C57BL/6 * DBA	decreased circulating cholesterol level	J:149005
	decreased circulating LDL cholesterol level	J:149005
Nr0b2^tm1Rus/Nr0b2^tm1Rus involves: 129P2/OlaHsd * C57BL/6	abnormal bile salt homeostasis	J:102129
	abnormal bile salt level	J:102129
	abnormal lipid homeostasis	J:102129
	abnormal liver physiology	J:102129
	increased circulating alanine transaminase level	J:102129
	increased circulating aspartate transaminase level	J:102129
	increased intestinal cholesterol absorption	J:102129

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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