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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mapk7
mitogen-activated protein kinase 7
MGI:1346347
59 phenotypes from 7 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mapk7b2b2346Clo/Mapk7b2b2346Clo
C57BL/6J-Mapk7b2b2346Clo 		abnormal myocardium compact layer morphology J:175213
atrioventricular septal defect J:175213
double outlet right ventricle J:175213
double outlet right ventricle with atrioventricular septal defect J:175213
hydronephrosis J:175213
muscular ventricular septal defect J:175213
polycystic kidney J:175213
ventricular septal defect J:175213
Mapk7tm1.1Ctr/Mapk7+
involves: 129S1/Sv * 129X1/SvJ 		increased fibroblast apoptosis J:132253
Mapk7tm1.1Ctr/Mapk7tm1.1Ctr
involves: 129S1/Sv * 129X1/SvJ 		increased fibroblast apoptosis J:132253
Mapk7tm1.1Jdl/Mapk7tm1.1Jdl
Not Specified 		abnormal vitelline vasculature morphology J:89215
embryonic lethality during organogenesis, complete penetrance J:89215
Mapk7tm1Jdl/Mapk7tm1Jdl
Not Specified 		no abnormal phenotype detected J:89215
Mapk7tm1Jdl/Mapk7tm1Jdl
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		abnormal apoptosis J:89215
abnormal blood vessel morphology J:89215
abnormal heart morphology J:89215
abnormal vascular permeability J:89215
cachexia J:89215
head tilt J:89215
hemorrhage J:89215
myocardial fiber degeneration J:89215
premature death J:89215
Mapk7tm1Jdl/Mapk7tm1Jdl
Tg(Myhca-cre)1Abel/0
Not Specified 		no abnormal phenotype detected J:89215
Mapk7tm1Jdl/Mapk7tm1Jdl
Tg(Tek-cre)12Flv/0
Not Specified 		abnormal endocardium morphology J:89215
abnormal heart development J:89215
abnormal vitelline vasculature morphology J:89215
embryonic lethality during organogenesis, complete penetrance J:89215
trabecula carnea hypoplasia J:89215
Mapk7tm1Jsca/Mapk7tm1Jsca
either: (involves: BALB/c) or (involves: C57BL/6) 		abnormal angiogenesis J:107620
abnormal brain development J:107620
abnormal digestive system development J:107620
abnormal head mesenchyme morphology J:107620
abnormal head morphology J:107620
abnormal placenta labyrinth morphology J:107620
abnormal placental labyrinth vasculature morphology J:107620
abnormal septum transversum morphology J:107620
abnormal vitelline vascular remodeling J:107620
embryonic growth retardation J:107620
embryonic lethality during organogenesis, complete penetrance J:107620
hemorrhage J:107620
intracerebral hemorrhage J:107620
small first pharyngeal arch J:107620
small second pharyngeal arch J:107620
thin myocardium J:107620
Mapk7tm1Kda/Mapk7tm1Kda
involves: 129S6/SvEvTac 		abnormal dorsal aorta morphology J:77725
abnormal heart development J:77725
abnormal heart right ventricle morphology J:77725
abnormal placenta vasculature J:77725
abnormal vascular development J:77725
abnormal vascular endothelial cell morphology J:77725
abnormal vascular smooth muscle morphology J:77725
abnormal vitelline vascular remodeling J:77725
abnormal vitelline vasculature morphology J:77725
absent vitelline blood vessels J:77725
decreased angiogenesis J:77725
decreased embryo size J:77725
embryonic lethality during organogenesis, complete penetrance J:77725
failure of heart looping J:77725
failure of vascular branching J:77725
pale yolk sac J:77725
pericardial edema J:77725
trabecula carnea hypoplasia J:77725
Mapk7tm1Wnt/Mapk7tm1Wnt
involves: C57BL/6 		abnormal dorsal aorta morphology J:80044
abnormal endocardium morphology J:80044
abnormal intersomitic vessel morphology J:80044
abnormal placental labyrinth vasculature morphology J:80044
abnormal vascular development J:80044
abnormal vascular endothelial cell development J:80044
abnormal vitelline vascular remodeling J:80044
decreased angiogenesis J:80044
decreased embryo size J:80044
decreased heart right ventricle size J:80044
distended pericardium J:80044
embryonic growth arrest J:80044
embryonic lethality during organogenesis, complete penetrance J:80044
failure of vascular branching J:80044
heart left ventricle hypertrophy J:80044
pale yolk sac J:80044
pallor J:80044
small heart J:80044
thin myocardium J:80044
trabecula carnea hypoplasia J:80044
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory