Sh3bp2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sh3bp2
SH3-domain binding protein 2
MGI:1346349

70 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sh3bp2^tm1.1Ics/Sh3bp2⁺ involves: 129S2/SvPas * C57BL/6	abnormal circulating cytokine level	J:221901
	abnormal macrophage physiology	J:221901
	increased susceptibility to bacterial infection	J:221901
	increased tumor necrosis factor secretion	J:221901
Sh3bp2^tm1.1Ics/Sh3bp2^tm1.1Ics involves: 129S2/SvPas * C57BL/6	abnormal circulating cytokine level	J:221901
	abnormal skeleton morphology	J:221901
	enlarged lymph nodes	J:221901
	head/neck swellings	J:221901
	increased circulating interleukin-6 level	J:221901
	increased circulating interleukin-12 level	J:221901
	increased circulating tumor necrosis factor level	J:221901
	increased inflammatory response	J:221901
	increased monocyte cell number	J:221901
	increased tumor necrosis factor secretion	J:221901
Sh3bp2^{tm1b(KOMP)Wtsi}/Sh3bp2^{tm1b(KOMP)Wtsi} C57BL/6N-Sh3bp2^{tm1b(KOMP)Wtsi}/Tcp	increased circulating alanine transaminase level	J:211773
	increased circulating aspartate transaminase level	J:211773
	short tibia	J:211773
Sh3bp2^tm1Bjro/Sh3bp2⁺ involves: 129S4/SvJae * BALB/cJ * C57BL/6J	abnormal bone ossification	J:117880
	abnormal bone structure	J:117880
	abnormal compact bone morphology	J:117880
	abnormal enzyme/coenzyme level	J:117880
	abnormal long bone morphology	J:117880
	abnormal osteoclast differentiation	J:117880
	abnormal osteoclast physiology	J:117880
	decreased bone trabecula number	J:117880
	decreased trabecular bone volume	J:117880
	normal immune system phenotype	J:117880
	increased osteoblast cell number	J:117880
	increased osteoclast cell number	J:117880
Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro involves: 129S4/SvJae * BALB/cJ * C57BL/6J	abnormal B cell number	J:117880
	abnormal bone ossification	J:117880
	abnormal bone structure	J:117880
	abnormal compact bone morphology	J:117880
	abnormal craniofacial bone morphology	J:117880
	abnormal enzyme/coenzyme level	J:117880
	abnormal immune system organ morphology	J:117880
	abnormal jaw morphology	J:117880
	abnormal long bone morphology	J:117880
	abnormal macrophage physiology	J:117880
	abnormal neurocranium morphology	J:117880
	abnormal osteoclast differentiation	J:117880
	abnormal osteoclast physiology	J:117880
	abnormal skeleton physiology	J:117880
	alveolar process atrophy	J:117880
	blepharitis	J:117880
	decreased bone mineral density	J:117880
	decreased bone trabecula number	J:117880
	decreased trabecular bone volume	J:117880
	dermatitis	J:117880
	enlarged lymph nodes	J:117880
	increased circulating tumor necrosis factor level	J:117880
	increased inflammatory response	J:117880
	increased osteoblast cell number	J:117880
	increased osteoclast cell number	J:117880
	increased spleen red pulp amount	J:117880
	joint inflammation	J:117880
	liver inflammation	J:117880
	lung inflammation	J:117880
	myositis	J:117880
	osteomyelitis	J:117880
	premature death	J:117880
	spinal cord inflammation	J:117880
	stomach inflammation	J:117880
Sh3bp2^{tm1c(KOMP)Wtsi}/Sh3bp2^{tm1c(KOMP)Wtsi} involves: C57BL/6N	abnormal compact bone morphology	J:243612
	increased bone mass	J:243612
	increased bone mineral density	J:243612
	increased bone trabecula number	J:243612
	increased compact bone thickness	J:243612
	increased trabecular bone thickness	J:243612
	increased trabecular bone volume	J:243612
Sh3bp2^tm1Geha/Sh3bp2^tm1Geha Not Specified	abnormal B cell number	J:110319
	abnormal B cell physiology	J:110319
	decreased B cell proliferation	J:110319
	normal immune system phenotype	J:110319
	increased pre-B cell number	J:110319
Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl B6.129P2-Sh3bp2^tm1Rtpl	abnormal B cell number	J:121380
	abnormal marginal zone B cell physiology	J:121380
	abnormal spleen marginal zone morphology	J:121380
	decreased B cell proliferation	J:121380
	decreased B-1 B cell number	J:121380
	decreased IgA level	J:121380
	decreased IgG1 level	J:121380
	decreased IgG3 level	J:121380
	decreased IgM level	J:121380
	decreased immunoglobulin level	J:121380
	decreased pro-B cell number	J:121380
	decreased transitional stage B cell number	J:121380
	increased B cell apoptosis	J:121380
	increased marginal zone B cell number	J:121380
Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl involves: 129P2/OlaHsd * C57BL/6	abnormal circulating cytokine level	J:221901
	abnormal interleukin-6 secretion	J:221901
	abnormal macrophage physiology	J:221901
	decreased tumor necrosis factor secretion	J:221901
	impaired macrophage phagocytosis	J:221901

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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