Bace1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bace1
beta-site APP cleaving enzyme 1
MGI:1346542

38 phenotypes from 9 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Bace1^tm1.1Slr/Bace1^tm1.1Slr involves: 129P2/OlaHsd * C57BL/6 * CBA	no abnormal phenotype detected	J:77414
Bace1^tm1Bux/Bace1^tm1Bux involves: 129S5/SvEvBrd * C57BL/6	no abnormal phenotype detected	J:89370
Bace1^tm1Cdi/Bace1^tm1Cdi involves: 129P2/OlaHsd * C57BL/6J	abnormal anxiety-related response	J:86936
	abnormal muscle physiology	J:86936
	decreased exploration in new environment	J:86936
	improved righting response	J:86936
Bace1^tm1Nn/Bace1^tm1Nn Not Specified	abnormal cell physiology	J:100272
Bace1^tm1Pcw/Bace1^tm1Pcw involves: 129S1/Sv * 129X1/SvJ	abnormal myelin sheath morphology	J:116162
	abnormal myelination	J:116162
	decreased grip strength	J:116162
	decreased thermal nociceptive threshold	J:116162
Bace1^tm1Pcw/Bace1^tm1Pcw involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal dendritic spine morphology	J:133643
	abnormal dishabituation	J:133643
	abnormal locomotor activation	J:123534
	abnormal long-term depression	J:123534
	abnormal response to novel object	J:133643
	abnormal spatial learning	J:123534
	abnormal spatial reference memory	J:123534
	abnormal spatial working memory	J:123534, J:133643
	abnormal startle reflex	J:133643
	decreased anxiety-related response	J:123534
	decreased prepulse inhibition	J:133643
	enhanced behavioral response to xenobiotic	J:133643
	enhanced paired-pulse facilitation	J:123534
	impaired passive avoidance behavior	J:133643
Bace1^tm1Psa/Bace1⁺ involves: 129S2/SvPas * C57BL/6	decreased muscle spindle number	J:199150
Bace1^tm1Psa/Bace1^tm1Psa either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CD-1)	abnormal channel response	J:100925
	abnormal nervous system physiology	J:100925
	cachexia	J:100925
	decreased anxiety-related response	J:100925
	decreased body weight	J:100925
	hyperactivity	J:100925
	postnatal growth retardation	J:100925
	postnatal lethality, incomplete penetrance	J:100925
Bace1^tm1Psa/Bace1^tm1Psa involves: 129S2/SvPas * C57BL/6	abnormal gait	J:199150
	abnormal muscle spindle morphology	J:199150
	decreased muscle spindle number	J:199150
	demyelination	J:199150
	impaired coordination	J:199150
Bace1^tm1Psa/Bace1^tm1Psa involves: 129S2/SvPas * C57BL/6J	normal pigmentation phenotype	J:197977
Bace1^tm1Vas/Bace1^tm1Vas involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:67736
Bace1^tm2Psa/Bace1^tm2Psa involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6	decreased anxiety-related response	J:100925
	increased locomotor activity	J:100925
	postnatal lethality, incomplete penetrance	J:100925
Bace1^tm2Slr/Bace1^tm2Slr involves: 129S5/SvEvBrd * C57BL/6	no abnormal phenotype detected	J:77414

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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