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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bace1
beta-site APP cleaving enzyme 1
MGI:1346542
17 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bace1tm1Pcw/Bace1+
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-CDK5R1/GFP)337Lht/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		astrocytosis J:177847
normal behavior/neurological phenotype J:177847
decreased brain weight J:177847
hippocampal neuron degeneration J:177847
normal nervous system phenotype J:177847
Bace1tm1Pcw/Bace1+
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J 		abnormal spatial learning J:123534
abnormal spatial reference memory J:123534
amyloid beta deposits J:123534
amyloidosis J:123534
Bace1tm1Pcw/Bace1tm1Pcw
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J 		abnormal locomotor activation J:123534
normal behavior/neurological phenotype J:123534
decreased anxiety-related response J:123534
normal nervous system phenotype J:123534
Bace1tm1Psa/Bace1tm1Psa
Bace2tm1Bdes/Bace2tm1Bdes
either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J) or (involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * CD-1) 		abnormal nervous system physiology J:100925
cachexia J:100925
decreased body size J:100925
postnatal lethality, incomplete penetrance J:100925
Bace1tm1Psa/Bace1tm1Psa
Nrg1tm4.1Cbm/Nrg1+
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ * C57BL/6 		abnormal muscle spindle morphology J:199150
decreased muscle spindle number J:199150
Bace1tm1Psa/Bace1tm1Psa
Tg(Thy1-Nrg1*I)1Kan/0
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		decreased muscle spindle number J:199150
normal nervous system phenotype J:199150
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory