Esrra Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Esrra
estrogen related receptor, alpha
MGI:1346831

38 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Esrra^{tm1.1(KOMP)Vlcg}/Esrra^{tm1.1(KOMP)Vlcg} C57BL/6N-Esrra^{tm1.1(KOMP)Vlcg}/J	decreased vertical activity	J:211773
	hyperactivity	J:211773
	increased circulating alanine transaminase level	J:211773
	increased grip strength	J:211773
	increased mean corpuscular hemoglobin concentration	J:211773
	increased startle reflex	J:211773
	shortened PQ interval	J:211773
Esrra^tm1.1Ics/Esrra^tm1.1Ics Tg(Col1a1-cre)1Kry/0 involves: 129S2/SvPas * FVB	abnormal skeleton physiology	J:195925
	abnormal trabecular bone morphology	J:195925
Esrra^tm1Dgen/Esrra^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:101679
Esrra^tm1Vgi/Esrra^tm1Vgi involves: 129S1/Sv * 129X1/SvJ	abnormal bone structure	J:160910
	abnormal osteoclast differentiation	J:160910
	abnormal trabecular bone morphology	J:160910
	decreased bone marrow cell number	J:160910
	decreased bone resorption	J:160910
	decreased osteoclast cell number	J:160910
	extramedullary hematopoiesis	J:160910
	increased osteoblast cell number	J:160910
	increased splenocyte number	J:160910
	increased trabecular bone volume	J:160910
	osteopetrosis	J:160910
Esrra^tm1Vgi/Esrra^tm1Vgi involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal adipose tissue physiology	J:86433
	abnormal cellular respiration	J:119525
	abnormal lipid homeostasis	J:86433
	decreased body weight	J:86433
	decreased epididymal fat pad weight	J:86433
	decreased fat cell mitochondrial DNA content	J:119525
	decreased inguinal fat pad weight	J:86433
	decreased mitochondrial number	J:119525
	decreased percent body fat/body weight	J:86433
	decreased retroperitoneal fat pad weight	J:86433
	decreased white fat cell size	J:86433
	normal homeostasis/metabolism phenotype	J:86433
	impaired adaptive thermogenesis	J:119525
	increased brown fat cell lipid droplet size	J:119525
	increased lean body mass	J:86433
	increased percent water in carcass	J:86433
	increased triglyceride level	J:119525
Esrra^tm1Vgi/Esrra^tm1Vgi involves: C57BL/6	decreased susceptibility to diet-induced obesity	J:86433

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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