About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nr5a1
nuclear receptor subfamily 5, group A, member 1
MGI:1346833
104 phenotypes from 10 alleles in 12 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Amhr2tm3(cre)Bhr/Amhr2+
Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		abnormal endometrial gland development J:145805
abnormal endometrial gland morphology J:145805
abnormal estrous cycle J:145805
abnormal ovarian follicle number J:91352, J:145805
abnormal ovary physiology J:145805
abnormal ovulation J:91352
abnormal seminiferous tubule morphology J:91352
abnormal testis cord formation J:91352
abnormal testis development J:91352
abnormal uterus morphology J:145805
absent corpus luteum J:91352, J:145805
absent estrous cycle J:145805
absent sexual maturation J:91352
arrest of spermatogenesis J:91352
cryptorchism J:91352
decreased circulating estradiol level J:145805
decreased circulating testosterone level J:91352
decreased endometrial gland number J:145805
decreased granulosa cell proliferation J:145805
decreased ovary weight J:145805
decreased primary ovarian follicle number J:145805
decreased primordial ovarian follicle number J:145805
decreased secondary ovarian follicle number J:145805
decreased superovulation rate J:145805
decreased tertiary ovarian follicle number J:145805
decreased uterus weight J:145805
female infertility J:91352, J:145805
impaired ovarian folliculogenesis J:145805
increased circulating follicle stimulating hormone level J:145805
internal male genitalia hypoplasia J:91352
male infertility J:91352
ovarian follicular cyst J:91352
ovary hemorrhage J:91352
ovary hypoplasia J:91352, J:145805
prolonged estrous cycle J:145805
short estrus J:145805
small adrenal glands J:91352
small testis J:91352
testis hypoplasia J:91352
thin myometrium J:145805
Cyp11b2tm1.1(cre)Brlt/Cyp11b2+
Nr5a1tm2Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		abnormal adrenal gland zona glomerulosa morphology J:204614
Gt(ROSA)26Sortm2(CAG-Nr5a1)Fjd/Gt(ROSA)26Sor+
Pgrtm2(cre)Lyd/Pgr+
involves: 129S1/Sv * 129X1/SvJ 		abnormal decidualization J:269597
abnormal endometrial gland development J:269597
abnormal endometrial gland morphology J:269597
abnormal endometrium morphology J:269597
abnormal uterus morphology J:269597
enlarged endometrial glands J:269597
enlarged uterine horn J:269597
female infertility J:269597
uterus cyst J:269597
uterus inflammation J:269597
Nr5a1em1Kemi/Nr5a1+
involves: C57BL/6 * DBA/2 		normal mortality/aging J:277036
normal reproductive system phenotype J:277036
small adrenal glands J:277036
small testis J:277036
Nr5a1em1Kemi/Nr5a1em1Kemi
involves: C57BL/6 * DBA/2 		abnormal testis morphology J:277036
absent adrenal gland J:277036
postnatal lethality, complete penetrance J:277036
normal reproductive system phenotype J:277036
secondary sex reversal J:277036
small gonad J:277036
Nr5a1tm1.1Hain/Nr5a1+
Not Specified 		retention of the adrenal gland x-zone J:175843
Nr5a1tm1.1Hain/Nr5a1tm1.1Hain
Not Specified 		abnormal aldosterone level J:175843
abnormal corticosterone level J:175843
abnormal progesterone level J:175843
abnormal testis development J:175843
abnormal testis morphology J:175843
abnormal testosterone level J:175843
decreased testis weight J:175843
female infertility J:175843
increased Leydig cell number J:175843
infertility J:175843
male infertility J:175843
normal mortality/aging J:175843
oligozoospermia J:175843
retention of the adrenal gland x-zone J:175843
seminiferous tubule degeneration J:175843
small adrenal glands J:175843
Nr5a1tm1Enl/Nr5a1tm1Enl
involves: 129S4/SvJae 		abnormal hypothalamus morphology J:28971
abnormal pituitary gland morphology J:28971
abnormal primary sex determination J:28971
abnormal secondary sex determination J:28971
absent adrenal gland J:28971
absent ovary J:28971
absent testes J:28971
agonadal J:28971
decreased gonadotroph cell number J:28971
decreased ventromedial hypothalamic nucleus size J:28971
postnatal lethality, complete penetrance J:28971
secondary sex reversal J:28971
Nr5a1tm1Jmi/Nr5a1tm1Jmi
involves: 129X1/SvJ 		abnormal primary sex determination J:35577
absent adrenal gland J:35577
absent ovary J:35577
absent testes J:35577
agonadal J:35577
postnatal lethality, complete penetrance J:35577
secondary sex reversal J:35577
Nr5a1tm1Klp/Nr5a1tm1Klp
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal gonadal ridge morphology J:35576
abnormal primary sex determination J:35576
absent adrenal gland J:35576
absent ovary J:35576
absent testes J:35576
agonadal J:35576
postnatal lethality, complete penetrance J:35576
postnatal lethality, incomplete penetrance J:28763
premature death J:28763
secondary sex reversal J:35576
Nr5a1tm1Klp/Nr5a1tm1Klp
involves: 129P2/OlaHsd * C57BL/6 * FVB 		abnormal innervation J:83384
abnormal neuron differentiation J:83384
abnormal ventromedial hypothalamic nucleus morphology J:83384
Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd 		decreased ovary weight J:145805
decreased superovulation rate J:145805
ovary hypoplasia J:145805
Nr5a1tm2.1Hain/Nr5a1tm2.1Hain
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:193956
Nr5a1tm2.1Klp/Nr5a1tm2.1Klp
involves: 129P2/OlaHsd 		absent adrenal gland J:66593
agonadal J:66593
perinatal lethality, complete penetrance J:66593
Nr5a1tm2Klp/Nr5a1tm2.1Klp
Tg(Cga-cre)3Sac/0
involves: 129P2/OlaHsd * C57BL/6J * SJL 		abnormal female reproductive system morphology J:66593
abnormal Leydig cell morphology J:66593
abnormal male reproductive system morphology J:66593
abnormal spermatid morphology J:66593
abnormal spermatogenesis J:66593
absent corpus luteum J:66593
absent mature ovarian follicles J:66593
absent sexual maturation J:66593
anovulation J:66593
cryptorchism J:66593
decreased circulating follicle stimulating hormone level J:66593
decreased circulating luteinizing hormone level J:66593
decreased follicle stimulating hormone level J:66593
decreased Leydig cell number J:66593
decreased luteinizing hormone level J:66593
decreased male germ cell number J:66593
delayed vaginal opening J:66593
external male genitalia hypoplasia J:66593
female infertility J:66593
internal male genitalia hypoplasia J:66593
male infertility J:66593
ovary hypoplasia J:66593
prostate gland hypoplasia J:66593
seminal vesicle hypoplasia J:66593
small gonad J:66593
testis hypoplasia J:66593
uterus hypoplasia J:66593
Nr5a1tm2Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:66593
Nr5a1tm2Klp/Nr5a1tm2Klp
Tg(Cga-cre)3Sac/0
involves: 129P2/OlaHsd * C57BL/6J * SJL 		abnormal sex gland morphology J:70412
abnormal sexual interaction J:70412
absent corpus luteum J:70412
absent mature ovarian follicles J:70412
absent sexual maturation J:70412
decreased circulating follicle stimulating hormone level J:70412
decreased circulating luteinizing hormone level J:70412
decreased Leydig cell number J:70412
decreased ovary weight J:70412
decreased testis weight J:70412
female infertility J:70412
impaired ovarian folliculogenesis J:70412
male infertility J:70412
prostate gland hypoplasia J:70412
seminal vesicle hypoplasia J:70412
small gonad J:70412
small ovary J:70412
small testis J:70412
uterus hypoplasia J:70412
Nr5a1tm3Klp/Nr5a1tm3Klp
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal reproductive system morphology J:28763
absent adrenal gland J:28763
absent ovary J:28763
absent testes J:28763
agonadal J:28763
decreased body weight J:28763
postnatal lethality, complete penetrance J:28763
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory