Nr5a2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nr5a2
nuclear receptor subfamily 5, group A, member 2
MGI:1346834

37 phenotypes from 6 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Alb^{tm1(cre/ERT2)Mtz}/Alb⁺ Nr5a2^tm1Sjns/Nr5a2^tm1Sjns involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL	abnormal bile salt level	J:129068
	abnormal feces composition	J:129068
	abnormal feces lipid level	J:129068
	abnormal intestinal lipid absorption	J:129068
	increased feces bile salt level	J:129068
Nr5a2^tm1Auw/Nr5a2⁺ involves: 129P2/OlaHsd	abnormal colon morphology	J:123697
	abnormal crypts of Lieberkuhn morphology	J:123697
	colonic necrosis	J:123697
	edema	J:123697
	increased susceptibility to induced colitis	J:123697
Nr5a2^tm1Auw/Nr5a2⁺ involves: 129P2/OlaHsd * C57BL/6J	abnormal crypts of Lieberkuhn morphology	J:92508
Nr5a2^tm1Auw/Nr5a2⁺ involves: C57BL/6J	decreased circulating testosterone level	J:118368
	decreased epididymis weight	J:118368
	decreased seminal vesicle weight	J:118368
Nr5a2^tm1Auw/Nr5a2^tm1Auw involves: 129P2/OlaHsd * C57BL/6J	prenatal lethality, complete penetrance	J:92508
Nr5a2^tm1Bel/Nr5a2⁺ involves: 129/Sv * C57BL/6 * SJL	abnormal bile salt level	J:89523
	abnormal pregnancy	J:124199
	decreased circulating cholesterol level	J:91695
	decreased circulating progesterone level	J:124199
	increased uterus weight	J:124199
	reduced female fertility	J:124199
	normal reproductive system phenotype	J:124199
Nr5a2^tm1Bel/Nr5a2^tm1Bel involves: 129/Sv * C57BL/6 * SJL	abnormal amniotic cavity morphology	J:91695
	abnormal ectoderm development	J:91695
	abnormal germ layer development	J:91695
	abnormal mesoderm development	J:91695
	absent amniotic cavity	J:91695
	embryonic lethality between implantation and somite formation, complete penetrance	J:91695
Nr5a2^tm1Lex/Nr5a2⁺ involves: 129	prenatal lethality, incomplete penetrance	J:97625
Nr5a2^tm1Lex/Nr5a2^tm1Lex involves: 129	abnormal ectoderm development	J:97625
	abnormal embryo development	J:97625
	abnormal proamniotic cavity morphology	J:97625
	abnormal visceral endoderm morphology	J:97625
	decreased embryo size	J:97625
	embryonic lethality between implantation and somite formation, incomplete penetrance	J:97625
	embryonic lethality during organogenesis, complete penetrance	J:97625
Nr5a2^tm1Sakl/Nr5a2^tm1Sakl Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA	abnormal bile composition	J:135822
	decreased circulating aspartate transaminase level	J:135822
	decreased circulating cholesterol level	J:135822
Nr5a2^tm1Sakl/Nr5a2^tm1Sakl Tg(Vil1-cre)997Gum/0 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL	decreased circulating aspartate transaminase level	J:135822
	decreased circulating cholesterol level	J:135822
	normal digestive/alimentary phenotype	J:135822
Nr5a2^tm1Sjns/Nr5a2^tm1Sjns Tg(Vil1-cre/ERT2)23Syr/? involves: 129/Sv * C57BL/6 * DBA/2 * SJL	colonic necrosis	J:123697
	increased susceptibility to induced colitis	J:123697
Nr5a2^tm3.1Sjns/Nr5a2^tm3.1Sjns B6J.B6N(Cg)-Nr5a2^tm3.1Sjns	abnormal bile salt homeostasis	J:215556

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