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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mapk8
mitogen-activated protein kinase 8
MGI:1346861
52 phenotypes from 4 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mapk8tm1.1Jcbr/Mapk8tm1.1Jcbr
involves: 129S4/SvJae * C57BL/6 		decreased body length J:195844
decreased body weight J:195844
decreased circulating leptin level J:195844
decreased food intake J:195844
decreased gonadal fat pad weight J:195844
decreased insulin secretion J:195844
decreased percent body fat/body weight J:195844
decreased susceptibility to diet-induced obesity J:195844
normal homeostasis/metabolism phenotype J:195844
improved glucose tolerance J:195844
increased insulin sensitivity J:195844
increased respiratory quotient J:195844
Mapk8tm1Flv/Mapk8tm1Flv
B6.129S1-Mapk8tm1Flv 		abnormal epidermis stratum basale morphology J:93433
absent keratohyalin granules J:93433
thin epidermis J:93433
Mapk8tm1Flv/Mapk8tm1Flv
B6.129S1-Mapk8tm1Flv/J 		normal liver/biliary system phenotype J:113452
Mapk8tm1Flv/Mapk8tm1Flv
involves: 129S1/Sv 		abnormal cytokine secretion J:51510
abnormal T-helper 1 cell differentiation J:51510
cardiac fibrosis J:108253
decreased cardiac muscle contractility J:108253
increased cardiomyocyte apoptosis J:108253
increased incidence of tumors by chemical induction J:75228
increased response of heart to induced stress J:108253
increased T cell proliferation J:51510
Mapk8tm1Flv/Mapk8tm1Flv
involves: 129S1/Sv * C57BL/6 		abnormal enzyme/coenzyme activity J:112737
abnormal myocardium layer morphology J:102152
decreased cardiomyocyte apoptosis J:102152
Mapk8tm1Jcbr/Mapk8tm1Jcbr
Tg(Ckmm-cre)5Khn/0
involves: 129S4/SvJae * C57BL/6 * FVB 		normal growth/size/body region phenotype J:195844
normal homeostasis/metabolism phenotype J:195844
Mapk8tm1Jcbr/Mapk8tm1Jcbr
Tg(Nes-cre)1Kln/0
involves: 129S4/SvJae * C57BL/6 * SJL 		abnormal glucose homeostasis J:158650
decreased body length J:158650
decreased body weight J:158650
decreased circulating glucose level J:158650
decreased circulating growth hormone level J:158650
decreased circulating insulin level J:158650
decreased circulating insulin-like growth factor I level J:158650
decreased food intake J:158650
decreased liver triglyceride level J:158650
decreased liver weight J:158650
decreased susceptibility to diet-induced hepatic steatosis J:158650
improved glucose tolerance J:158650
increased circulating adiponectin level J:158650
increased circulating triiodothyronine level J:158650
increased insulin sensitivity J:158650
increased oxygen consumption J:158650
weight loss J:158650
Mapk8tm1Wag/Mapk8tm1Wag
B6.129P2-Mapk8tm1Wag 		abnormal fat cell morphology J:80452
decreased circulating glucose level J:80452
decreased circulating insulin level J:80452
decreased subcutaneous adipose tissue amount J:80452
decreased susceptibility to diet-induced obesity J:80452
decreased total body fat amount J:80452
improved glucose tolerance J:80452
increased epididymal fat pad weight J:80452
increased insulin sensitivity J:80452
Mapk8tm1Wag/Mapk8tm1Wag
involves: 129P2/OlaHsd 		abnormal T cell activation J:78190
decreased T cell apoptosis J:78190
decreased T cell proliferation J:78190
Mapk8tm1Wag/Mapk8tm1Wag
involves: 129P2/OlaHsd * C57BL/6 		abnormal retina outer nuclear layer morphology J:292691
increased b-wave amplitude J:292691
increased retina cone cell number J:292691
increased retina rod cell number J:292691
normal vision/eye phenotype J:292691
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory