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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mapk9
mitogen-activated protein kinase 9
MGI:1346862
103 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Apoetm1Bres/Apoetm1Bres
Mapk9tm1Flv/Mapk9tm1Flv
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		abnormal macrophage morphology J:94044
abnormal macrophage physiology J:94044
decreased susceptibility to atherosclerosis J:94044
increased macrophage derived foam cell number J:94044
Krastm4Tyj/Kras+
Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9tm1Mka
involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		increased lung tumor incidence J:170904
Map3k1tm1Yxia/Map3k1+
Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1 		early eyelid opening J:176244
Mapk8tm1Flv/Mapk8tm1Flv
Mapk9tm1.1Rjd/Mapk9tm1.1Rjd
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 		decreased fibroblast proliferation J:112737
decreased keratinocyte migration J:112737
increased fibroblast apoptosis J:112737
increased fibroblast cell migration J:112737
Mapk8tm1Flv/Mapk8tm1Flv
Mapk9tm1Flv/Mapk9+
B6.129S-Mapk9tm1Flv Mapk8tm1Flv 		abnormal epidermal layer morphology J:93433
abnormal eye morphology J:83385, J:93433
abnormal fungiform papillae morphology J:93433
abnormal hair follicle development J:93433
abnormal intestinal epithelium morphology J:93433
abnormal intestinal mucosa morphology J:93433
abnormal kidney morphology J:83385
abnormal lens morphology J:83385
abnormal lung development J:93433
abnormal nephron morphology J:83385
abnormal tongue epithelium morphology J:93433
abnormal tongue morphology J:93433
decreased hair follicle number J:93433
delayed intestine development J:93433
dilated renal tubule J:83385
eyelids open at birth J:83385, J:93433
infertility J:93433
pallor J:93433
postnatal lethality, incomplete penetrance J:83385, J:93433
respiratory distress J:93433
retina coloboma J:83385
small lens J:83385
thick pulmonary interalveolar septum J:93433
Mapk8tm1Flv/Mapk8tm1Flv
Mapk9tm1Flv/Mapk9tm1Flv
involves: 129S1/Sv * 129S2/SvPas 		abnormal neural tube morphology J:54653
decreased hindbrain apoptosis J:54653
dilated heart J:54653
embryonic lethality during organogenesis, complete penetrance J:54653
exencephaly J:54653
increased embryonic neuroepithelium apoptosis J:54653
increased forebrain apoptosis J:54653
Mapk8tm1Rjd/Mapk8tm1Rjd
Mapk9tm1Flv/Mapk9tm1Flv
involves: 129S2/SvPas * C57BL/6J 		increased fibroblast apoptosis J:131766
Mapk8tm1Rjd/Mapk8tm1Rjd
Mapk9tm1Flv/Mapk9tm1Flv
Tg(Col2a1-cre)1Bhr/0
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL 		abnormal gait J:277201
abnormal intervertebral disk morphology J:277201
abnormal knee joint morphology J:277201
abnormal nucleus pulposus morphology J:277201
abnormal sternebra morphology J:277201
abnormal sternocostal joint morphology J:277201
abnormal tail position or orientation J:277201
abnormal vertebrae morphology J:277201
abnormal vertebral epiphyseal plate morphology J:277201
calcified intervertebral disk J:277201
decreased body size J:277201
distended abdomen J:277201
fusion of vertebral arches J:277201
fusion of vertebral bodies J:277201
ischuria J:277201
paraphimosis J:277201
premature death J:277201
scoliosis J:277201
sternebra fusion J:277201
vertebral fusion J:277201
Mapk8tm1Rjd/Mapk8tm1Rjd
Mapk9tm2.1Rjd/Mapk9tm2.1Rjd
Lyz2tm1(cre)Ifo/Lyz2+
B6J.Cg-Lyz2tm1(cre)Ifo Mapk9tm2.1Rjd Mapk8tm1Rjd 		abnormal chemokine level J:192551
abnormal circulating chemokine level J:192551
abnormal circulating cytokine level J:192551
abnormal gluconeogenesis J:192551
abnormal glucose homeostasis J:192551
abnormal glycogen homeostasis J:192551
abnormal lipid homeostasis J:192551
abnormal macrophage differentiation J:192551
abnormal macrophage physiology J:192551
decreased circulating glucose level J:192551
decreased circulating insulin level J:192551
decreased inflammatory response J:192551
decreased lean body mass J:192551
decreased macrophage cell number J:192551
decreased macrophage cytokine production J:192551
decreased pancreatic beta cell proliferation J:192551
normal homeostasis/metabolism phenotype J:192551
impaired macrophage chemotaxis J:192551
improved glucose tolerance J:192551
increased insulin secretion J:192551
increased insulin sensitivity J:192551
small pancreatic islets J:192551
Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9+
involves: 129 		abnormal T cell activation J:78190
decreased T cell apoptosis J:78190
decreased T cell proliferation J:78190
Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9tm1Mka
involves: 129 		abnormal T cell activation J:78190
decreased T cell apoptosis J:78190
decreased T cell proliferation J:78190
Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9tm1Mka
involves: 129 * C57BL/6 		normal nervous system phenotype J:58622
Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9+
involves: 129 		abnormal T cell activation J:78190
decreased T cell apoptosis J:78190
decreased T cell proliferation J:78190
Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9+
involves: 129 * C57BL/6 		abnormal brain development J:58622
abnormal cerebral hemisphere morphology J:58622
abnormal diencephalon morphology J:58622
abnormal embryonic neuroepithelial layer differentiation J:58622
absent brain ventricles J:58622
exencephaly J:58622
incomplete rostral neuropore closure J:58622
postnatal lethality, incomplete penetrance J:58622
Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9+
involves: 129/Sv * 129P2/OlaHsd 		abnormal eyelid morphology J:170904
Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9tm1Mka
involves: 129 * C57BL/6 		abnormal embryonic neuroepithelial layer differentiation J:58622
abnormal forebrain development J:58622
decreased hindbrain apoptosis J:58622
decreased physiological sensitivity to xenobiotic J:103476
embryonic growth retardation J:58622
embryonic lethality during organogenesis, complete penetrance J:58622
incomplete rostral neuropore closure J:58622
increased forebrain apoptosis J:58622
increased hindbrain apoptosis J:58622
Mapk9tm1Flv/Mapk9tm1Flv
Tnftm2Gkl/Tnf+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J 		normal immune system phenotype J:108572
increased apoptosis J:108572
small intestinal inflammation J:108572
Mapk10tm1Flv/Mapk10tm1Flv
Mapk9tm1Flv/Mapk9tm1Flv
B6.129S-Mapk9tm1Flv Mapk10tm1Flv 		abnormal dopamine level J:87428
abnormal somatic motor system morphology J:96192
normal behavior/neurological phenotype J:87428
decreased susceptibility to dopaminergic neuron neurotoxicity J:87428
Mapk10tm1Flv/Mapk10tm1Flv
Mapk9tm1Flv/Mapk9tm1Flv
involves: 129S1/Sv * 129S2/SvPas 		normal nervous system phenotype J:54653
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory