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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Map2k1
mitogen-activated protein kinase kinase 1
MGI:1346866
41 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gata4tm1.1Jmol/Gata4tm1.1Jmol
Tg(Myh6-Map2k1*)1Jmol/0
involves: 129 * C57BL/6 * FVB 		abnormal heart size J:174537
Gata4tm1.1Sad/Gata4tm1.1Sad
Tg(Myh6-Map2k1*)1Jmol/0
involves: 129S1/Sv * 129X1/SvJ * FVB 		cardiac hypertrophy J:174537
Gata4tm1.1Sad/Gata4tm1.1Sad
Tg(Myh6-Map2k1*)1Jmol/0
Tg(Myh7-cre)1Jmk/0
involves: 129S1/Sv * 129X1/SvJ * FVB 		abnormal heart size J:174537
Hivep3tm3Glm/Hivep3+
Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
Tg(Prrx1-cre)1Cjt/0
involves: 129 * C57BL/6J * SJL * SJL/J 		increased bone mass J:201597
Krastm1Bbd/Kras+
Map2k1tm1Chrn/Map2k1tm1Chrn
involves: 129S1/Sv * 129X1/SvJ 		increased lung non-small cell carcinoma incidence J:172200
premature death J:172200
Krastm1Bbd/Kras+
Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL 		decreased classified tumor incidence J:172200
premature death J:172200
Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129/Sv * C57BL/6J * CBA/J * SJL 		abnormal eye distance/ position J:144862
abnormal outer ear morphology J:144862
absent tongue J:144862
mandible hypoplasia J:144862
persistent truncus arteriosus J:144862
short maxilla J:144862
Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
involves: 129/Sv * C57BL/6J * SJL 		abnormal crypts of Lieberkuhn morphology J:172200
abnormal intestine morphology J:172200
premature death J:172200
Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
Tg(Cyp17a1-icre)AJako/0
involves: 129/Sv * C57BL/6 * C57BL/6J * SJL 		abnormal circulating androgen level J:278979
abnormal testosterone level J:278979
decreased copulatory plug deposition J:278979
decreased Leydig cell number J:278979
decreased litter size J:278979
decreased seminal vesicle weight J:278979
decreased testes secretion J:278979
increased circulating luteinizing hormone level J:278979
reduced male fertility J:278979
normal reproductive system phenotype J:278979
Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
Tg(KRT14-cre)1Efu/?
involves: 129/Sv * C57BL/6J * SJL 		abnormal outer ear morphology J:122484
abnormal tongue epithelium morphology J:122484
abnormal vibrissa follicle morphology J:122484
decreased body size J:122484
decreased body weight J:122484
decreased hair follicle cell proliferation J:122484
decreased hair follicle number J:122484
eyelids open at birth J:122484
impaired skin barrier function J:122484
increased keratinocyte apoptosis J:122484
neonatal lethality, incomplete penetrance J:122484
shiny skin J:122484
skin hypoplasia J:122484
translucent skin J:122484
Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
Tg(KRT14-cre/ERT2)1Ipc/?
involves: 129/Sv * C57BL/6J * SJL 		abnormal tongue epithelium morphology J:122484
skin hypoplasia J:122484
Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
Tg(KRT14-RAF1/ESR1)1Pkha/?
involves: 129/Sv * C57BL/6 * C57BL/6J * SJL 		skin hypoplasia J:122484
Mapk1tm1Melo/Mapk1+
Tg(Myh6-Map2k1*)1Jmol/0
involves: 129S2/SvPas * FVB 		cardiac hypertrophy J:124903
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Myh6-Map2k1*)1Jmol/0
involves: 129/Sv * FVB/N 		cardiac hypertrophy J:124903
Tg(Myh6-Map2k1*)1Jmol/0
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0
involves: FVB 		abnormal heart left ventricle morphology J:234490
increased cardiac muscle contractility J:234490
increased heart weight J:234490
thick interventricular septum J:234490
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory