Map2k4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Map2k4
mitogen-activated protein kinase kinase 4
MGI:1346869

27 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Map2k4^tm1Ctr/Map2k4^tm1Ctr involves: C57BL/6	no abnormal phenotype detected	J:129038
Map2k4^tm1Ctr/Map2k4^tm1Ctr Tg(ACTA1-cre)1Mll/? involves: C57BL/6	impaired coordination	J:129038
Map2k4^tm1Ctr/Map2k4^tm1Ctr Tg(CAG-cre/Esr1)5Amc/0 involves: C57BL/6 CBA	normal nervous system phenotype	J:178060
Map2k4^tm1Ctr/Map2k4^tm1Ctr Tg(Nes-cre)1Kln/? involves: C57BL/6 * SJL	abnormal cerebellar granule layer morphology	J:129038
	abnormal cerebellar Purkinje cell layer	J:129038
	abnormal gait	J:129038
	abnormal neuron differentiation	J:129038
	abnormal Purkinje cell morphology	J:129038
	ataxia	J:129038
	decreased anterior commissure size	J:129038
	decreased body weight	J:129038
	decreased corpus callosum size	J:129038
	impaired coordination	J:129038
	impaired righting response	J:129038
	postnatal growth retardation	J:129038
	postnatal lethality, complete penetrance	J:129038
	tremors	J:129038
Map2k4^tm1Flv/Map2k4^tm1Flv involves: 129S1/Sv	embryonic lethality, complete penetrance	J:77628
Map2k4^tm1Lizon/Map2k4^tm1Lizon involves: 129S1/Sv	abnormal liver bud morphology	J:48772
	abnormal liver development	J:48772
	decreased hepatocyte number	J:48772
	dilated liver sinusoidal space	J:48772
	increased hepatocyte apoptosis	J:48772
	liver hemorrhage	J:48772
	pallor	J:48772
	prenatal lethality, complete penetrance	J:48772
Map2k4^tm1Pngr/Map2k4^tm1Pngr involves: 129P2/OlaHsd * C57BL/6	abnormal liver development	J:51597
	anemia	J:51597
	embryonic lethality during organogenesis, complete penetrance	J:51597

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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