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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Map2k7
mitogen-activated protein kinase kinase 7
MGI:1346871
11 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Krastm4Tyj/Kras+
Map2k7tm1.1Twad/Map2k7tm1.2Twad
B6.Cg-Krastm4Tyj Map2k7tm1.1Twad/Map2k7tm1.2Twad 		abnormal DNA repair J:170904
increased lung adenocarcinoma incidence J:170904
increased lung tumor incidence J:170904
premature death J:170904
Krastm4Tyj/Kras+
Map2k7tm1.1Twad/Map2k7tm1.2Twad
Tg(Trp53)bSrn/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA 		normal neoplasm J:170904
Krastm4Tyj/Kras+
Map2k7tm1.1Twad/Map2k7tm1.2Twad
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6 		increased lung adenocarcinoma incidence J:170904
increased lung tumor incidence J:170904
Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(APPswe,PSEN1dE9)85Dbo/0
Tg(Camk2a-cre/ERT2)2Gsc/0
involves: C3H * C57BL/6 * FVB/N 		abnormal neurite morphology J:178060
amyloid beta deposits J:178060
Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(CAG-cre/Esr1*)5Amc/0
involves: C57BL/6 * CBA 		decreased neuron apoptosis J:178060
Map2k7tm1.1Twad/Map2k7tm1.2Twad
Tg(MMTV-cre)4Mam/0
Tg(MMTV-Erbb2)1Pv/0
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N 		increased mammary adenocarcinoma incidence J:170904
increased mammary gland tumor incidence J:170904
mammary gland hyperplasia J:170904
premature death J:170904
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory