Map3k1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Map3k1
mitogen-activated protein kinase kinase kinase 1
MGI:1346872

54 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Map3k1^Ga/Map3k1^Ga involves: BALB/cGa	abnormal eyelid development	J:95944
	cornea opacity	J:95944
	eyelids open at birth	J:95944
Map3k1^goya/Map3k1⁺ involves: C3H * C57BL/6J	increased cochlear outer hair cell number	J:226897
Map3k1^goya/Map3k1^goya involves: C3H * C57BL/6J	abnormal eye morphology	J:226897
	abnormal eye physiology	J:226897
	abnormal pinna reflex	J:226897
	abnormal retina layer morphology	J:226897
	cochlear outer hair cell degeneration	J:226897
	deafness	J:226897
	early eyelid opening	J:226897
	exophthalmos	J:226897
	normal hearing/vestibular/ear phenotype	J:226897
	increased cochlear outer hair cell number	J:226897
	increased or absent threshold for auditory brainstem response	J:226897
	microphthalmia	J:226897
	organ of Corti degeneration	J:226897
Map3k1^goya/Map3k1^tm1Yxia involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	deafness	J:226897
	increased or absent threshold for auditory brainstem response	J:226897
Map3k1^{tm1a(KOMP)Wtsi}/Map3k1⁺ C57BL/6N-Map3k1^{tm1a(KOMP)Wtsi}/Wtsi	abnormal retina morphology	J:211773
	decreased circulating fructosamine level	J:211773
	decreased fasting circulating glucose level	J:211773
	increased bone mineral content	J:211773
	increased circulating free fatty acids level	J:211773
	increased lean body mass	J:211773
	increased red blood cell distribution width	J:211773
Map3k1^{tm1a(KOMP)Wtsi}/Map3k1^{tm1a(KOMP)Wtsi} C57BL/6N-Map3k1^{tm1a(KOMP)Wtsi}/Wtsi	preweaning lethality, incomplete penetrance	J:211773
Map3k1^tm1Glj/Map3k1^tm1Glj involves: 129S/SvEv	abnormal eyelid development	J:62909
	abnormal heart left ventricle morphology	J:78068
	abnormal vascular smooth muscle physiology	J:108989
	abnormal vascular wound healing	J:108989
	congestive heart failure	J:78068
	decreased heart ventricle muscle contractility	J:78068
	eyelids open at birth	J:62909
	heart inflammation	J:78068
	normal immune system phenotype	J:62909
	impaired fibroblast cell migration	J:62909
	increased cardiomyocyte apoptosis	J:78068
	increased response of heart to induced stress	J:78068
	increased susceptibility to induced morbidity/mortality	J:78068
Map3k1^tm1Yxia/Map3k1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	increased cochlear outer hair cell number	J:226897
Map3k1^tm1Yxia/Map3k1^tm1Yxia involves: 129/Sv * C57BL/6	abnormal eyelid development	J:85346
	abnormal eyelid fusion	J:85346
	abnormal eyelid margin morphology	J:85346
	abnormal eyelid morphology	J:85346
	abnormal keratinocyte morphology	J:85346
	eyelids open at birth	J:85346
Map3k1^tm1Yxia/Map3k1^tm1Yxia involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	cochlear outer hair cell degeneration	J:226897
	deafness	J:226897
	decreased cochlear inner hair cell number	J:226897
	increased cochlear outer hair cell number	J:226897
	increased or absent threshold for auditory brainstem response	J:226897
	organ of Corti degeneration	J:226897
Map3k1^tm1Yxia/Map3k1^tm1Yxia involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal cornea morphology	J:176244
	abnormal cornea stroma morphology	J:176244
	abnormal iris morphology	J:176244
	abnormal Muller cell morphology	J:176244
	abnormal retina development	J:176244
	abnormal retina morphology	J:176244
	abnormal retina outer nuclear layer morphology	J:176244
	abnormal retina pigment epithelium morphology	J:176244
	cornea opacity	J:176244
	early eyelid opening	J:176244
	increased cornea stroma thickness	J:176244
	increased retina apoptosis	J:176244
	retina degeneration	J:176244
	retina gliosis	J:176244
	retina neovascularization	J:176244
	retina photoreceptor degeneration	J:176244
	thin retina outer nuclear layer	J:176244

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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