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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Map3k3
mitogen-activated protein kinase kinase kinase 3
MGI:1346874
25 phenotypes from 5 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Map3k3tm1.1Mlkn/Map3k3tm1.2Mlkn
Nfatc1tm1.1(cre)Bz/Nfatc1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac 		embryonic lethality during organogenesis J:238897
thin myocardium J:238897
Map3k3tm1Bisu/Map3k3tm1Bisu
Not Specified 		abnormal heart atrium morphology J:60748
abnormal heart development J:60748
abnormal heart morphology J:60748
abnormal myocardium layer morphology J:60748
abnormal placental labyrinth vasculature morphology J:60748
abnormal vascular development J:60748
abnormal vitelline vascular remodeling J:60748
decreased angiogenesis J:60748
embryonic lethality during organogenesis, complete penetrance J:60748
microcephaly J:60748
trabecula carnea hypoplasia J:60748
Map3k3tm1Bisu/Map3k3tm2Bisu
Tg(Lck-cre)548Jxm/0
involves: C57BL/6 * CBA 		abnormal T cell physiology J:145923
abnormal T cell proliferation J:145923
decreased CD4-positive, alpha-beta T cell number J:145923
decreased CD8-positive, alpha-beta T cell number J:145923
spleen hypoplasia J:145923
Map3k3tm1Kuro/Map3k3tm1Kuro
Tg(Lck-cre)1Jtak/0
involves: C57BL/6 		decreased CD4-positive, alpha-beta T cell number J:147103
decreased CD8-positive, alpha-beta T cell number J:147103
decreased double-positive T cell number J:147103
decreased interferon-gamma secretion J:147103
decreased interleukin-2 secretion J:147103
decreased single-positive T cell number J:147103
decreased T cell proliferation J:147103
decreased thymocyte number J:147103
increased double-negative T cell number J:147103
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory