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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Map3k4
mitogen-activated protein kinase kinase kinase 4
MGI:1346875
27 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Map3k4byg/Map3k4byg
involves: C3H/HeH * C57BL/6J 		abnormal primary sex determination J:153050
abnormal testis cord formation J:153050
abnormal testis development J:153050
absent testis cords J:153050
edema J:153050
exencephaly J:153050
lethality throughout fetal growth and development, complete penetrance J:153050
ovotestis J:153050
primary sex reversal J:153050
normal reproductive system phenotype J:153050
spina bifida J:153050
Map3k4byg/Map3k4tm1Flv
involves: 129S6/SvEvTac * C3H/HeH * C57BL/6J 		abnormal neural tube morphology J:153050
primary sex reversal J:153050
Map3k4tm1Flv/Map3k4tm1Flv
involves: 129S6/SvEvTac * C57BL/6 		abnormal T-helper 1 physiology J:90112
decreased body size J:90112
decreased interferon-gamma secretion J:90112
perinatal lethality, incomplete penetrance J:90112
Map3k4tm1Flv/Map3k4tm1Flv
involves: 129S6/SvEvTac * C57BL/6J 		primary sex reversal J:153050
Map3k4tm1Glj/Map3k4+
involves: 129S6/SvEvTac * C57BL/6 		abnormal neural tube morphology J:101350
abnormal sternum morphology J:101350
abnormal vertebrae morphology J:101350
asymmetric sternocostal joints J:101350
decreased rib number J:101350
Map3k4tm1Glj/Map3k4tm1Glj
involves: 129S6/SvEvTac * C57BL/6 		abnormal caudal vertebrae morphology J:101350
abnormal neural tube morphology J:101350
abnormal vertebrae morphology J:101350
asthenozoospermia J:101350
asymmetric sternocostal joints J:101350
craniorachischisis J:101350
exencephaly J:101350
male infertility J:101350
oligozoospermia J:101350
omphalocele J:101350
perinatal lethality, incomplete penetrance J:101350
scoliosis J:101350
spina bifida J:101350
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory