Map3k4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Map3k4
mitogen-activated protein kinase kinase kinase 4
MGI:1346875

27 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Map3k4^byg/Map3k4^byg involves: C3H/HeH * C57BL/6J	abnormal primary sex determination	J:153050
	abnormal testis cord formation	J:153050
	abnormal testis development	J:153050
	absent testis cords	J:153050
	edema	J:153050
	exencephaly	J:153050
	lethality throughout fetal growth and development, complete penetrance	J:153050
	ovotestis	J:153050
	primary sex reversal	J:153050
	normal reproductive system phenotype	J:153050
	spina bifida	J:153050
Map3k4^byg/Map3k4^tm1Flv involves: 129S6/SvEvTac * C3H/HeH * C57BL/6J	abnormal neural tube morphology	J:153050
	primary sex reversal	J:153050
Map3k4^tm1Flv/Map3k4^tm1Flv involves: 129S6/SvEvTac * C57BL/6	abnormal T-helper 1 physiology	J:90112
	decreased body size	J:90112
	decreased interferon-gamma secretion	J:90112
	perinatal lethality, incomplete penetrance	J:90112
Map3k4^tm1Flv/Map3k4^tm1Flv involves: 129S6/SvEvTac * C57BL/6J	primary sex reversal	J:153050
Map3k4^tm1Glj/Map3k4⁺ involves: 129S6/SvEvTac * C57BL/6	abnormal neural tube morphology	J:101350
	abnormal sternum morphology	J:101350
	abnormal vertebrae morphology	J:101350
	asymmetric sternocostal joints	J:101350
	decreased rib number	J:101350
Map3k4^tm1Glj/Map3k4^tm1Glj involves: 129S6/SvEvTac * C57BL/6	abnormal caudal vertebrae morphology	J:101350
	abnormal neural tube morphology	J:101350
	abnormal vertebrae morphology	J:101350
	asthenozoospermia	J:101350
	asymmetric sternocostal joints	J:101350
	craniorachischisis	J:101350
	exencephaly	J:101350
	male infertility	J:101350
	oligozoospermia	J:101350
	omphalocele	J:101350
	perinatal lethality, incomplete penetrance	J:101350
	scoliosis	J:101350
	spina bifida	J:101350

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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