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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Map3k7
mitogen-activated protein kinase kinase kinase 7
MGI:1346877
130 phenotypes from 11 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Map3k7tm1Aki/Map3k7tm1.1Aki
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell physiology J:112597
decreased B cell proliferation J:112597
decreased B-1 B cell number J:112597
decreased IgG1 level J:112597
decreased IgG3 level J:112597
decreased IgG level J:112597
decreased immunoglobulin level J:112597
Map3k7Gt(XB444)Byg/Map3k7Gt(XB444)Byg
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality during organogenesis, complete penetrance J:102721
open neural tube J:102721
wavy neural tube J:102721
Map3k7Gt(XB444)Byg/Map3k7Gt(XB444)Byg
involves: 129P2/OlaHsd * C57BL/6J 		abnormal blood vessel morphology J:107401
abnormal dorsal aorta morphology J:107401
abnormal heart morphology J:107401
abnormal myocardial trabeculae morphology J:107401
abnormal pharyngeal arch artery morphology J:107401
abnormal vascular development J:107401
abnormal vascular regression J:107401
abnormal vascular smooth muscle morphology J:107401
abnormal vitelline vascular remodeling J:107401
abnormal vitelline vasculature morphology J:107401
decreased embryo size J:107401
edema J:107401
embryo tissue necrosis J:107401
embryonic lethality during organogenesis, complete penetrance J:107401
hemorrhage J:107401
microcephaly J:107401
pericardial edema J:107401
short tail J:107401
small heart J:107401
thin myocardium compact layer J:107401
Map3k7tm1.1Aki/Map3k7tm1.1Aki
involves: 129P2/OlaHsd * C57BL/6 		absent fibroblast proliferation J:112597
embryonic lethality during organogenesis, complete penetrance J:112597
Map3k7tm1.1Gkl/Map3k7tm1.1Gkl
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		decreased circulating interleukin-10 level J:211916
decreased interleukin-10 secretion J:211916
increased circulating interleukin-1 beta level J:211916
increased circulating tumor necrosis factor level J:211916
increased inflammatory response J:211916
increased interleukin-1 beta secretion J:211916
increased interleukin-6 secretion J:211916
increased interleukin-10 secretion J:211916
increased susceptibility to endotoxin shock J:211916
increased susceptibility to induced morbidity/mortality J:211916
increased tumor necrosis factor secretion J:211916
Map3k7tm1.1Mds/Map3k7tm1.1Mds
Not Specified 		abnormal blood vessel morphology J:117108
abnormal vitelline vasculature morphology J:117108
embryonic lethality during organogenesis, complete penetrance J:117108
Map3k7tm1.2Gkl/Map3k7tm1.2Gkl
involves: C57BL/6 * FVB/N 		prenatal lethality, complete penetrance J:211916
Map3k7tm1Aki/Map3k7tm1Aki
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal bile duct morphology J:160521
abnormal hepatocyte morphology J:160521
focal hepatic necrosis J:160521
increased circulating bilirubin level J:160521
increased hepatocyte proliferation J:160521
Map3k7tm1Aki/Map3k7tm1Aki
Tg(Alb1-cre)7Gsc/0
involves: 129P2/OlaHsd * FVB/N 		abnormal bile duct morphology J:160521
abnormal hepatocyte morphology J:160521
abnormal liver morphology J:160521
bile duct proliferation J:160521
focal hepatic necrosis J:160521
increased circulating alanine transaminase level J:160521
increased circulating alkaline phosphatase level J:160521
increased circulating aspartate transaminase level J:160521
increased circulating bilirubin level J:160521
increased circulating glutamate dehydrogenase level J:160521
increased hepatocellular carcinoma incidence J:160521
increased hepatocyte apoptosis J:160521
increased hepatocyte proliferation J:160521
intrahepatic cholestasis J:160521
liver fibrosis J:160521
liver inflammation J:160521
premature death J:160521
Map3k7tm1Aki/Map3k7tm1Aki
Tg(Lck-cre)1Jtak/0
involves: 129P2/OlaHsd 		abnormal colon morphology J:112837
abnormal intestinal goblet cell morphology J:112837
abnormal intestine morphology J:112837
abnormal spleen morphology J:112837
abnormal T cell activation J:112837
absent regulatory T cells J:112837
chronic diarrhea J:112837
colitis J:112837
decreased CD4-positive, alpha-beta T cell number J:112837
decreased CD8-positive, alpha-beta T cell number J:112837
decreased single-positive T cell number J:112837
decreased T cell number J:112837
decreased T cell proliferation J:112837
enlarged lymph nodes J:112837
enlarged spleen J:112837
increased memory T cell number J:112837
intestinal ulcer J:112837
rectal prolapse J:112837
spleen hyperplasia J:112837
weight loss J:112837
Map3k7tm1Aki/Map3k7tm1Aki
Tg(Lck-cre)1Jtak/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal alpha-beta intraepithelial T cell morphology J:238318
abnormal CD4-positive, alpha-beta T cell physiology J:238318
abnormal cytokine level J:238318
abnormal intestinal epithelium physiology J:238318
abnormal intraepithelial T cell number J:238318
abnormal liver morphology J:238318
abnormal regulatory T cell number J:238318
abnormal regulatory T cell physiology J:238318
abnormal T cell morphology J:238318
colitis J:238318
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:238318
decreased NK T cell number J:238318
increased CD4-positive, alpha-beta T cell number J:238318
increased gamma-delta intraepithelial T cell number J:238318
increased interferon-gamma secretion J:238318
increased interleukin-17 secretion J:238318
Map3k7tm1Aki/Map3k7tm1Aki
Tg(Slco1c1-icre/ERT2)1Mash/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		normal behavior/neurological phenotype J:179050
decreased locomotor activity J:179050
normal growth/size/body region phenotype J:179050
normal homeostasis/metabolism phenotype J:179050
impaired febrile response J:179050
lethargy J:179050
Map3k7tm1Aki/Map3k7tm1Aki
Tg(Slco1c1-icre/ERT2)1Mash/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		normal behavior/neurological phenotype J:179050
normal homeostasis/metabolism phenotype J:179050
Map3k7tm1Aki/Map3k7tm1Aki
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * C3H * C57BL/6 		abnormal vascular development J:191285
abnormal vitelline vasculature morphology J:191285
normal cardiovascular system phenotype J:191285
decreased angiogenesis J:191285
embryonic lethality during organogenesis, complete penetrance J:191285
increased apoptosis J:191285
Map3k7tm1b(EUCOMM)Wtsi/Map3k7+
C57BL/6N-Map3k7tm1b(EUCOMM)Wtsi/H 		abnormal lens morphology J:211773
increased circulating alkaline phosphatase level J:211773
Map3k7tm1b(EUCOMM)Wtsi/Map3k7tm1b(EUCOMM)Wtsi
C57BL/6N-Map3k7tm1b(EUCOMM)Wtsi/H 		embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Map3k7tm1Mds/Map3k7tm1Mds
Tg(Myh6-cre)2182Mds/0
involves: FVB/N 		embryonic lethality during organogenesis, complete penetrance J:117108
Map3k7tm1Mis/Map3k7tm1Mis
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6J * CBA/J 		abnormal craniofacial morphology J:198588
abnormal secondary palate development J:198588
cleft secondary palate J:198588
decreased cranium height J:198588
failure of palatal shelf elevation J:198588
neonatal lethality, complete penetrance J:198588
palatal shelf hypoplasia J:198588
short mandible J:198588
short maxilla J:198588
Map3k7tm1Zjc/Map3k7tm1Zjc
Tg(Lck-cre)548Jxm/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA 		decreased CD4-positive, alpha-beta T cell number J:111794
decreased CD8-positive, alpha-beta T cell number J:111794
decreased T cell number J:111794
increased thymocyte apoptosis J:111794
Tg(CAG-Map3k7*K63W)1232Mds/0
Tg(Myh6-cre)2182Mds/0
involves: FVB/N 		abnormal atrial thrombosis J:117108
abnormal cardiovascular system physiology J:117108
abnormal heart morphology J:117108
abnormal myocardial fiber morphology J:117108
abnormal QRS complex J:117108
abnormal ventricle papillary muscle morphology J:117108
cardiac hypertrophy J:117108
cardiomyopathy J:117108
decreased locomotor activity J:117108
dilated heart ventricle J:117108
increased cardiac muscle glycogen level J:117108
periorbital edema J:117108
postnatal growth retardation J:117108
postnatal lethality, complete penetrance J:117108
prolonged QRS complex duration J:117108
shortened PR interval J:117108
thin ventricular wall J:117108
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory