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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Map3k8
mitogen-activated protein kinase kinase kinase 8
MGI:1346878
35 phenotypes from 10 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Map3k8M1Btlr/Map3k8+
C57BL/6J-Map3k8M1Btlr 		abnormal tumor necrosis factor secretion J:140986
decreased tumor necrosis factor secretion J:140986
prenatal lethality, incomplete penetrance J:140986
Map3k8M1Btlr/Map3k8M1Btlr
C57BL/6J-Map3k8M1Btlr 		abnormal response to infection J:140986
decreased interferon-alpha secretion J:140986
decreased interferon-beta secretion J:140986
decreased interleukin-1 beta secretion J:140986
decreased interleukin-6 secretion J:140986
decreased tumor necrosis factor secretion J:140986
impaired natural killer cell mediated cytotoxicity J:140986
increased interleukin-12b secretion J:140986
prenatal lethality, incomplete penetrance J:140986
Map3k8m2Btlr/Map3k8m2Btlr
C57BL/6J-Map3k8m2Btlr 		abnormal response to infection J:212899
Map3k8m3Btlr/Map3k8+
C57BL/6J-Map3k8m3Btlr 		decreased macrophage cytokine production J:224668
decreased tumor necrosis factor secretion J:224668
Map3k8m3Btlr/Map3k8m3Btlr
C57BL/6J-Map3k8m3Btlr 		decreased macrophage cytokine production J:224668
decreased tumor necrosis factor secretion J:224668
Map3k8M4Btlr/Map3k8+
C57BL/6J-Map3k8M4Btlr 		decreased tumor necrosis factor secretion J:254880
Map3k8M4Btlr/Map3k8M4Btlr
C57BL/6J-Map3k8M4Btlr 		decreased tumor necrosis factor secretion J:254880
Map3k8tm1.1Gkl/Map3k8tm1.1Gkl
Lyz2tm1(cre)Ifo/Lyz2+
involves: C57BL/6 * FVB/N 		normal homeostasis/metabolism phenotype J:193546
normal neoplasm J:193546
Map3k8tm1.1Gkl/Map3k8tm1.1Gkl
Tg(Col6a1-cre)1Gkl/0
involves: C57BL/6 * CBA * FVB/N 		abnormal colon morphology J:193546
abnormal enterocyte proliferation J:193546
decreased enterocyte apoptosis J:193546
normal homeostasis/metabolism phenotype J:193546
increased incidence of tumors by chemical induction J:193546
increased tumor growth/size J:193546
Map3k8tm1.1Gkl/Map3k8tm1.1Gkl
Tg(Vil1-cre)997Gum/0
involves: C57BL/6 * FVB/N * SJL 		normal homeostasis/metabolism phenotype J:193546
normal neoplasm J:193546
Map3k8tm1.2Gkl/Map3k8tm1.2Gkl
involves: 129 * C57BL/6J * FVB/N 		abnormal colon morphology J:193546
abnormal enterocyte proliferation J:193546
decreased colon length J:193546
decreased enterocyte apoptosis J:193546
decreased susceptibility to xenobiotic induced morbidity/mortality J:193546
decreased tumor necrosis factor secretion J:193546
diarrhea J:193546
increased incidence of tumors by chemical induction J:193546
increased physiological sensitivity to xenobiotic J:193546
increased susceptibility to weight loss J:193546
increased susceptibility to xenobiotic induced morbidity/mortality J:193546
increased tumor growth/size J:193546
rectal hemorrhage J:193546
Map3k8tm1b(KOMP)Wtsi/Map3k8tm1b(KOMP)Wtsi
C57BL/6N-Map3k8tm1b(KOMP)Wtsi/Ucd 		abnormal uterus morphology J:211773
Map3k8tm1Pnt/Map3k8tm1Pnt
involves: 129S1/Sv 		normal immune system phenotype J:142340, J:196528
Map3k8tm1Pnt/Map3k8tm1Pnt
involves: 129S1/Sv * C57BL/6J 		decreased susceptibility to endotoxin shock J:66503
decreased tumor necrosis factor secretion J:66503
normal immune system phenotype J:66503
Map3k8tm1Tmat/Map3k8tm1Tmat
involves: 129S/SvEv * C57BL/6 		abnormal cytokine secretion J:92844
abnormal dendritic cell antigen presentation J:92844
decreased IgE level J:92844
decreased IgG1 level J:92844
increased IgG2a level J:92844
increased T cell proliferation J:92844
Tg(Lck-Map3k8)3456Ngc/?
involves: C3H/HeJ * C57BL/6J 		increased T cell derived lymphoma incidence J:39450
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory