Map3k8 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Map3k8
mitogen-activated protein kinase kinase kinase 8
MGI:1346878

6 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Map3k8^tm1Pnt/Map3k8^tm1Pnt Nfkb1^tm1Sley/Nfkb1^tm1Sley involves: 129S1/Sv * 129S4/SvJae	decreased circulating interleukin-12b level	J:196528
	decreased interleukin-12b secretion	J:196528
	decreased tumor necrosis factor secretion	J:196528
Map3k8^tm1Pnt/Map3k8^tm1Pnt Tnf^tm2Gkl/Tnf⁺ involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	increased CD8-positive, alpha-beta T cell number	J:108572
	increased single-positive T cell number	J:108572
	small intestinal inflammation	J:108572
Map3k8^tm1Sley/Map3k8^tm1Sley Nfkb1^tm1Sley/Nfkb1^tm1Sley involves: 129S4/SvJae	decreased tumor necrosis factor secretion	J:196528

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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