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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Map3k8
mitogen-activated protein kinase kinase kinase 8
MGI:1346878
6 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Map3k8tm1Pnt/Map3k8tm1Pnt
Nfkb1tm1Sley/Nfkb1tm1Sley
involves: 129S1/Sv * 129S4/SvJae 		decreased circulating interleukin-12b level J:196528
decreased interleukin-12b secretion J:196528
decreased tumor necrosis factor secretion J:196528
Map3k8tm1Pnt/Map3k8tm1Pnt
Tnftm2Gkl/Tnf+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J 		increased CD8-positive, alpha-beta T cell number J:108572
increased single-positive T cell number J:108572
small intestinal inflammation J:108572
Map3k8tm1Sley/Map3k8tm1Sley
Nfkb1tm1Sley/Nfkb1tm1Sley
involves: 129S4/SvJae 		decreased tumor necrosis factor secretion J:196528
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory