Map3k12 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Map3k12
mitogen-activated protein kinase kinase kinase 12
MGI:1346881

27 phenotypes from 8 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Map3k12^{Gt(RRN366)Byg}/Map3k12^{Gt(RRN366)Byg} involves: 129P2/OlaHsd * C57BL/6	absent anterior commissure	J:125702
Map3k12^{Gt(RRN366)Byg}/Map3k12^{Gt(RRN366)Byg} involves: 129P2/OlaHsd * C57BL/6J	slow Wallerian degeneration	J:188476
Map3k12^tm1.1Adia/Map3k12^tm1.1Adia involves: C57BL/6 * C57BL/6J * SJL	slow Wallerian degeneration	J:188476
Map3k12^tm1.1Lewc/Map3k12^tm1.1Lewc Not Specified	abnormal dorsal root ganglion morphology	J:176956
	abnormal neuron differentiation	J:176956
	decreased neuron apoptosis	J:176956
Map3k12^tm1.1Lewc/Map3k12^tm1.1Lewc Tg(Mnx1-GFP)1Slp/0 Not Specified	increased motor neuron number	J:176956
	normal nervous system phenotype	J:176956
Map3k12^tm1.2Adia/Map3k12^tm1.2Adia involves: C57BL/6 * C57BL/6J * SJL	perinatal lethality	J:188476
	slow Wallerian degeneration	J:188476
Map3k12^{tm1b(EUCOMM)Hmgu}/Map3k12⁺ C57BL/6N-Map3k12^{tm1b(EUCOMM)Hmgu}/Bay	increased heart left ventricle size	J:211773
Map3k12^{tm1b(EUCOMM)Hmgu}/Map3k12^{tm1b(EUCOMM)Hmgu} C57BL/6N-Map3k12^{tm1b(EUCOMM)Hmgu}/Bay	preweaning lethality, complete penetrance	J:211773
Map3k12^tm1Lbh/Map3k12^tm1Lbh Not Specified	abnormal axon extension	J:236918
Map3k12^tm1Lbh/Map3k12^tm1Lbh Not Specified	abnormal cell physiology	J:236918
Map3k12^tm1Lewc/Map3k12^tm1Lewc Tg(CAG-cre/Esr1)5Amc/0 involves: C57BL/6 CBA	decreased retina ganglion cell number	J:196076
Map3k12^tm1Shir/Map3k12^tm1Shir B6.Cg-Mapk12^tm1Shir	abnormal anterior commissure morphology	J:115575
	abnormal anterior commissure pars anterior morphology	J:115575
	abnormal anterior commissure pars posterior morphology	J:115575
	abnormal brain internal capsule morphology	J:115575
	abnormal brain morphology	J:115575
	abnormal brain white matter morphology	J:115575
	abnormal cerebral cortex morphology	J:115575
	abnormal cingulum morphology	J:115575
	abnormal enzyme/coenzyme activity	J:115575
	abnormal olfactory bulb morphology	J:115575
	abnormal olfactory tract morphology	J:115575
	decreased corpus callosum size	J:115575
	decreased neuronal migration	J:115575
	postnatal lethality, complete penetrance	J:115575

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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