Cop1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cop1
COP1, E3 ubiquitin ligase
MGI:1347046

18 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cop1^{Gt(XR0177)Wtsi}/Cop1^{Gt(XR0177)Wtsi} involves: 129P2/OlaHsd	abnormal heart development	J:178271
	embryonic lethality during organogenesis, complete penetrance	J:178271
Cop1^{Gt(XR0653)1.1Wtsi}/Cop1^{Gt(XR0653)1.1Wtsi} involves: 129P2/OlaHsd * C57BL/6 * CBA	belly spot	J:178271
	decreased body weight	J:178271
	increased B cell derived lymphoma incidence	J:178271
	increased histiocytic sarcoma incidence	J:178271
	increased incidence of induced tumors	J:178271
	increased T cell derived lymphoma incidence	J:178271
	increased testicular teratoma incidence	J:178271
	increased tumor incidence	J:178271
	increased uterus tumor incidence	J:178271
Cop1^{Gt(XR0653)Wtsi}/Cop1^{Gt(XR0653)1.1Wtsi} involves: 129P2/OlaHsd * C57BL/6 * CBA	anemia	J:178271
	hydrops fetalis	J:178271
	lethality throughout fetal growth and development, incomplete penetrance	J:178271
Cop1^{Gt(XR0653)Wtsi}/Cop1^{Gt(XR0653)Wtsi} involves: 129P2/OlaHsd	abnormal heart development	J:178271
	embryonic lethality during organogenesis, complete penetrance	J:178271
Cop1^tm1.1Vmd/Cop1^tm2.1Vmd Tg(CAG-cre/Esr1)5Amc/0 involves: C57BL/6 C57BL/6N * CBA	abnormal prostate gland physiology	J:172653
Cop1^tm2.1Vmd/Cop1⁺ Tg(Pbsn-cre)4Prb/0 B6N.Cg-Cop1^tm2.1Vmd Tg(Pbsn-cre)4Prb	prostate gland hyperplasia	J:172653
Cop1^tm2.1Vmd/Cop1⁺ Tg(Pbsn-cre)4Prb/0 B6N.CgCop1^tm2.1Vmd Pten^tm1Hwu Tg(Pbsn-cre)4Prb	increased prostate gland adenocarcinoma incidence	J:172653
	increased prostate intraepithelial neoplasia incidence	J:172653
Cop1^tm2.1Vmd/Cop1^tm2.1Vmd Tg(Pbsn-cre)4Prb/0 B6N.Cg-Cop1^tm2.1Vmd Tg(Pbsn-cre)4Prb	abnormal prostate gland physiology	J:172653
	increased prostate intraepithelial neoplasia incidence	J:172653
	prostate gland hyperplasia	J:172653

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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