Grk6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Grk6
G protein-coupled receptor kinase 6
MGI:1347078

19 phenotypes from 1 allele in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Grk6^tm1.1Mca/Grk6⁺ involves: 129S4/SvJae * C57BL/6J	enhanced behavioral response to addictive substance	J:83191
	enhanced behavioral response to cocaine	J:83191
	increased locomotor activity	J:83191
Grk6^tm1.1Mca/Grk6^tm1.1Mca B6.129S4-Grk6^tm1.1Mca	abnormal glomerular mesangium morphology	J:225063
	abnormal T cell subpopulation ratio	J:225063
	decreased CD8-positive, alpha-beta T cell number	J:225063
	decreased CD8-positive, naive alpha-beta T cell number	J:225063
	enlarged spleen	J:225063
	glomerulonephritis	J:225063
	impaired macrophage phagocytosis	J:225063
	increased anti-double stranded DNA antibody level	J:225063
	increased IgG level	J:225063
	increased memory T cell number	J:225063
	increased spleen iron level	J:225063
	increased spleen weight	J:225063
	increased spleen white pulp amount	J:225063
	increased splenocyte number	J:225063
Grk6^tm1.1Mca/Grk6^tm1.1Mca involves: 129S4/SvJae * C57BL/6J	abnormal B cell physiology	J:76872
	abnormal T cell physiology	J:76872
	enhanced behavioral response to addictive substance	J:83191
	enhanced behavioral response to cocaine	J:83191
	increased locomotor activity	J:83191

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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