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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cul3
cullin 3
MGI:1347360
72 phenotypes from 7 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cul3em1Limi/Cul3+
C57BL/6N-Cul3em1Limi 		abnormal actin cytoskeleton morphology J:332937
abnormal brain morphology J:332937
abnormal dendrite morphology J:332937
abnormal entorhinal cortex morphology J:332937
abnormal fear/anxiety-related behavior J:332937
abnormal nervous system electrophysiology J:332937
abnormal response to novel object J:332937
abnormal response to social novelty J:332937
abnormal somatosensory cortex morphology J:332937
abnormal visual cortex morphology J:332937
normal behavior/neurological phenotype J:332937
normal craniofacial phenotype J:332937
decreased body size J:332937
decreased body weight J:332937
decreased brain size J:332937
decreased corpus callosum size J:332937
decreased dendritic spine length J:332937
decreased dentate gyrus size J:332937
decreased embryo size J:332937
normal embryo phenotype J:332937
hyperactivity J:332937
hypothalamus hyperplasia J:332937
impaired righting response J:332937
normal mortality/aging J:332937
normal reproductive system phenotype J:332937
small cerebellum J:332937
small olfactory bulb J:332937
thin cerebral cortex J:332937
normal vision/eye phenotype J:332937
Cul3em1Limi/Cul3em1Limi
C57BL/6N-Cul3em1Limi 		lethality throughout fetal growth and development, complete penetrance J:332937
Cul3tm1.1Arte/Cul3+
involves: C57BL/6J * C57BL/6N 		abnormal blood vessel physiology J:229424
abnormal pH regulation J:229424
decreased body length J:229424
decreased body weight J:229424
hyperkalemia J:229424
hypertension J:229424
increased aorta wall thickness J:229424
increased circulating aldosterone level J:229424
increased circulating chloride level J:229424
increased circulating magnesium level J:229424
increased circulating phosphate level J:229424
increased vasoconstriction J:229424
metabolic acidosis J:229424
Cul3tm1.1Arte/Cul3tm1.1Arte
involves: C57BL/6J * C57BL/6N 		prenatal lethality, complete penetrance J:229424
Cul3tm1.1Jdsr/Cul3tm1Jro
involves: 129S4/SvJaeSor * C57BL/6 * SJL 		prenatal lethality, complete penetrance J:122228
Cul3tm1Jdsr/Cul3+
Tg(GFAP-cre)25Mes/0
involves: 129S4/SvJaeSor * FVB/N 		abnormal action potential J:292173
abnormal CNS synaptic transmission J:292173
abnormal response to social novelty J:292173
normal behavior/neurological phenotype J:292173
decreased paired-pulse facilitation J:292173
normal growth/size/body region phenotype J:292173
increased anxiety-related response J:292173
increased dendritic spine density J:292173
increased miniature excitatory postsynaptic current frequency J:292173
increased miniature inhibitory postsynaptic current frequency J:292173
increased thigmotaxis J:292173
normal mortality/aging J:292173
normal nervous system phenotype J:292173
normal reproductive system phenotype J:292173
Cul3tm1Jdsr/Cul3+
Neurod6tm1(cre)Kan/Neurod6+
Tg(Thy1-EGFP)MJrs/0
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA 		abnormal response to social novelty J:292173
normal growth/size/body region phenotype J:292173
increased anxiety-related response J:292173
increased dendritic spine density J:292173
increased miniature excitatory postsynaptic current frequency J:292173
increased miniature inhibitory postsynaptic current frequency J:292173
increased thigmotaxis J:292173
normal mortality/aging J:292173
normal nervous system phenotype J:292173
normal reproductive system phenotype J:292173
Cul3tm1Jdsr/Cul3tm1Jdsr
involves: 129S4/SvJaeSor 		abnormal cell cycle J:122228
abnormal liver morphology J:122228
increased fibroblast apoptosis J:122228
increased liver weight J:122228
Cul3tm1Jdsr/Cul3tm1Jdsr
Neurod6tm1(cre)Kan/Neurod6+
Tg(Thy1-EGFP)MJrs/0
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA 		abnormal hippocampus morphology J:292173
abnormal stratification in cerebral cortex J:292173
absent corpus callosum J:292173
decreased body size J:292173
decreased brain weight J:292173
preweaning lethality J:292173
thin cerebral cortex J:292173
Cul3tm1Jdsr/Cul3tm1Jdsr
Tg(GFAP-cre)25Mes/0
involves: 129S4/SvJaeSor * FVB/N 		abnormal hippocampus morphology J:292173
abnormal stratification in cerebral cortex J:292173
absent corpus callosum J:292173
decreased body size J:292173
decreased brain weight J:292173
preweaning lethality J:292173
thin cerebral cortex J:292173
Cul3tm1Jdsr/Cul3tm1Jro
involves: 129S4/SvJaeSor * C57BL/6 * SJL 		prenatal lethality, complete penetrance J:122228
Cul3tm1Jro/Cul3+
involves: 129S4/SvJaeSor 		abnormal cell cycle J:122228
Cul3tm1Jro/Cul3tm1Jro
involves: 129S4/SvJaeSor * C57BL/6J 		abnormal extraembryonic ectoderm morphology J:57761
abnormal gastrulation J:57761
abnormal trophectoderm morphology J:57761
abnormal trophoblast giant cell morphology J:57761
absent amnion J:57761
decreased embryo size J:57761
disorganized extraembryonic tissue J:57761
embryonic lethality between implantation and somite formation, complete penetrance J:57761
Cul3tm1Suc/Cul3+
involves: C57BL/6 		normal cardiovascular system phenotype J:226618
increased circulating chloride level J:226618
Cul3tm1Suc/Cul3tm1Suc
involves: C57BL/6 		lethality, complete penetrance J:226618
Cul3tm2Suc/Cul3tm2Suc
involves: C57BL/6 		normal cardiovascular system phenotype J:226618
normal homeostasis/metabolism phenotype J:226618
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory