About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cul3
cullin 3
MGI:1347360
72 phenotypes from 7 alleles in 8 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Cul3em1Limi/Cul3+
C57BL/6N-Cul3em1Limi 		abnormal actin cytoskeleton morphology J:332937
abnormal brain morphology J:332937
abnormal dendrite morphology J:332937
abnormal entorhinal cortex morphology J:332937
abnormal fear/anxiety-related behavior J:332937
abnormal nervous system electrophysiology J:332937
abnormal response to novel object J:332937
abnormal response to social novelty J:332937
abnormal somatosensory cortex morphology J:332937
abnormal visual cortex morphology J:332937
normal behavior/neurological phenotype J:332937
normal craniofacial phenotype J:332937
decreased body size J:332937
decreased body weight J:332937
decreased brain size J:332937
decreased corpus callosum size J:332937
decreased dendritic spine length J:332937
decreased dentate gyrus size J:332937
decreased embryo size J:332937
normal embryo phenotype J:332937
hyperactivity J:332937
hypothalamus hyperplasia J:332937
impaired righting response J:332937
normal mortality/aging J:332937
normal reproductive system phenotype J:332937
small cerebellum J:332937
small olfactory bulb J:332937
thin cerebral cortex J:332937
normal vision/eye phenotype J:332937
Cul3em1Limi/Cul3em1Limi
C57BL/6N-Cul3em1Limi 		lethality throughout fetal growth and development, complete penetrance J:332937
Cul3tm1.1Arte/Cul3+
involves: C57BL/6J * C57BL/6N 		abnormal blood vessel physiology J:229424
abnormal pH regulation J:229424
decreased body length J:229424
decreased body weight J:229424
hyperkalemia J:229424
hypertension J:229424
increased aorta wall thickness J:229424
increased circulating aldosterone level J:229424
increased circulating chloride level J:229424
increased circulating magnesium level J:229424
increased circulating phosphate level J:229424
increased vasoconstriction J:229424
metabolic acidosis J:229424
Cul3tm1.1Arte/Cul3tm1.1Arte
involves: C57BL/6J * C57BL/6N 		prenatal lethality, complete penetrance J:229424
Cul3tm1.1Jdsr/Cul3tm1Jro
involves: 129S4/SvJaeSor * C57BL/6 * SJL 		prenatal lethality, complete penetrance J:122228
Cul3tm1Jdsr/Cul3+
Tg(GFAP-cre)25Mes/0
involves: 129S4/SvJaeSor * FVB/N 		abnormal action potential J:292173
abnormal CNS synaptic transmission J:292173
abnormal response to social novelty J:292173
normal behavior/neurological phenotype J:292173
decreased paired-pulse facilitation J:292173
normal growth/size/body region phenotype J:292173
increased anxiety-related response J:292173
increased dendritic spine density J:292173
increased miniature excitatory postsynaptic current frequency J:292173
increased miniature inhibitory postsynaptic current frequency J:292173
increased thigmotaxis J:292173
normal mortality/aging J:292173
normal nervous system phenotype J:292173
normal reproductive system phenotype J:292173
Cul3tm1Jdsr/Cul3+
Neurod6tm1(cre)Kan/Neurod6+
Tg(Thy1-EGFP)MJrs/0
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA 		abnormal response to social novelty J:292173
normal growth/size/body region phenotype J:292173
increased anxiety-related response J:292173
increased dendritic spine density J:292173
increased miniature excitatory postsynaptic current frequency J:292173
increased miniature inhibitory postsynaptic current frequency J:292173
increased thigmotaxis J:292173
normal mortality/aging J:292173
normal nervous system phenotype J:292173
normal reproductive system phenotype J:292173
Cul3tm1Jdsr/Cul3tm1Jdsr
involves: 129S4/SvJaeSor 		abnormal cell cycle J:122228
abnormal liver morphology J:122228
increased fibroblast apoptosis J:122228
increased liver weight J:122228
Cul3tm1Jdsr/Cul3tm1Jdsr
Neurod6tm1(cre)Kan/Neurod6+
Tg(Thy1-EGFP)MJrs/0
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA 		abnormal hippocampus morphology J:292173
abnormal stratification in cerebral cortex J:292173
absent corpus callosum J:292173
decreased body size J:292173
decreased brain weight J:292173
preweaning lethality J:292173
thin cerebral cortex J:292173
Cul3tm1Jdsr/Cul3tm1Jdsr
Tg(GFAP-cre)25Mes/0
involves: 129S4/SvJaeSor * FVB/N 		abnormal hippocampus morphology J:292173
abnormal stratification in cerebral cortex J:292173
absent corpus callosum J:292173
decreased body size J:292173
decreased brain weight J:292173
preweaning lethality J:292173
thin cerebral cortex J:292173
Cul3tm1Jdsr/Cul3tm1Jro
involves: 129S4/SvJaeSor * C57BL/6 * SJL 		prenatal lethality, complete penetrance J:122228
Cul3tm1Jro/Cul3+
involves: 129S4/SvJaeSor 		abnormal cell cycle J:122228
Cul3tm1Jro/Cul3tm1Jro
involves: 129S4/SvJaeSor * C57BL/6J 		abnormal extraembryonic ectoderm morphology J:57761
abnormal gastrulation J:57761
abnormal trophectoderm morphology J:57761
abnormal trophoblast giant cell morphology J:57761
absent amnion J:57761
decreased embryo size J:57761
disorganized extraembryonic tissue J:57761
embryonic lethality between implantation and somite formation, complete penetrance J:57761
Cul3tm1Suc/Cul3+
involves: C57BL/6 		normal cardiovascular system phenotype J:226618
increased circulating chloride level J:226618
Cul3tm1Suc/Cul3tm1Suc
involves: C57BL/6 		lethality, complete penetrance J:226618
Cul3tm2Suc/Cul3tm2Suc
involves: C57BL/6 		normal cardiovascular system phenotype J:226618
normal homeostasis/metabolism phenotype J:226618
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory