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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Foxc1
forkhead box C1
MGI:1347466
213 phenotypes from 5 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Foxc1ch/Foxc1+
CHMU/Le 		abnormal anterior eye segment morphology J:61775
abnormal canal of Schlemm morphology J:61775
abnormal ciliary process morphology J:61775
abnormal iridocorneal angle J:61775
abnormal trabecular meshwork morphology J:61775
absent Schlemm's canal J:61775
anterior iris synechia J:61775
cataract J:61775
ciliary body hypoplasia J:61775
cornea vascularization J:61775
mydriasis J:61775
normal vision/eye phenotype J:61775
Foxc1ch/Foxc1+
involves: C57BL/6 * CHMU/Le 		bifid ureter J:60834
duplex kidney J:60834
Foxc1ch/Foxc1+
involves: CBA * STOCK Tyrc f 		abnormal cervical atlas morphology J:5191
abnormal foramen magnum morphology J:5191
abnormal kidney vasculature morphology J:5191
abnormal renal/urinary system morphology J:5191
abnormal reproductive system morphology J:5191
abnormal right renal artery morphology J:5191
abnormal sternum morphology J:5191
abnormal thyroid cartilage morphology J:5191
ectopic ovary J:5191
ectopic testis J:5191
hydronephrosis J:5191
hydroureter J:5191
normal nervous system phenotype J:5191
Foxc1ch/Foxc1ch
CHMU/LeJ 		abnormal sternocostal joint morphology J:221866
abnormal vertebrae development J:221866
decreased fetal size J:221866
delayed endochondral bone ossification J:221866
failure of sternum ossification J:221866
increased width of hypertrophic chondrocyte zone J:221866
short limbs J:221866
Foxc1ch/Foxc1ch
involves: C57BL/6 * CHMU/Le 		abnormal mesonephros morphology J:60834
abnormal Wolffian duct morphology J:60834
bifid ureter J:60834
blind ureter J:60834
duplex kidney J:60834
ectopic ovary J:60834
ectopic testis J:60834
ectopic ureter J:60834
ectopic ureteric bud J:60834
hydroureter J:60834
Foxc1ch/Foxc1ch
involves: CBA * STOCK Tyrc f 		abnormal arytenoid cartilage morphology J:14980
abnormal axial skeleton morphology J:14980
abnormal brain development J:5191, J:75733
abnormal brain ventricular system morphology J:75733
abnormal carpal bone morphology J:14980
abnormal cartilage development J:14980, J:75733
abnormal cartilage morphology J:75733
abnormal cerebellum development J:5191
abnormal cerebral aqueduct morphology J:75733
abnormal cerebral cortex morphology J:75733
abnormal cervical vertebrae morphology J:14980
abnormal choroid plexus morphology J:75733
abnormal craniofacial bone morphology J:14980
abnormal craniofacial development J:14980, J:75733
abnormal cricoid cartilage morphology J:14980
abnormal femur morphology J:14980
abnormal fibula morphology J:14980
abnormal forebrain development J:5191
abnormal fourth ventricle morphology J:75733
abnormal hindlimb morphology J:14980
abnormal hyoid bone morphology J:14980
abnormal kidney arterial blood vessel morphology J:5191
abnormal kidney development J:5191
abnormal kidney morphology J:5191
abnormal kidney venous blood vessel morphology J:5191
abnormal laryngeal cartilage morphology J:14980
abnormal lateral ventricle morphology J:75733
abnormal limb bone morphology J:14980
abnormal mesonephros morphology J:5191
abnormal metacarpal bone morphology J:14980
abnormal metanephros morphology J:5191
abnormal metatarsal bone morphology J:14980
abnormal nasal capsule morphology J:75733
abnormal nervous system development J:5191
abnormal neurocranium morphology J:14980, J:75733
abnormal notochord morphology J:75733
abnormal occipital bone morphology J:14980
abnormal patella morphology J:14980
abnormal phalanx morphology J:14980
abnormal pituitary diverticulum morphology J:5191
abnormal pituitary gland development J:75733
abnormal Reichert's cartilage morphology J:14980
abnormal rib development J:14980
abnormal rib morphology J:14980
abnormal roof plate morphology J:5191
abnormal scapula morphology J:14980
abnormal skeleton development J:14980
abnormal sphenoid bone morphology J:14980
abnormal spinal cord morphology J:5191
abnormal sternebra morphology J:14980
abnormal sternum morphology J:14980
abnormal sternum ossification J:5191
abnormal striatum morphology J:75733
abnormal tarsal bone morphology J:14980
abnormal third ventricle morphology J:75733
abnormal thyroid cartilage morphology J:14980
abnormal tibia morphology J:14980
abnormal tracheal cartilage morphology J:14980
abnormal trigeminal ganglion morphology J:75733
abnormal triquetrum morphology J:14980
abnormal ureter development J:5191
abnormal urogenital fold morphology J:5191
abnormal vertebrae development J:14980
abnormal vertebral arch morphology J:14980
abnormal vertebral transverse process morphology J:14980
abnormal vibrissa number J:75733
abnormal Wolffian duct morphology J:5191
abnormal xiphoid process morphology J:14980
absent epiglottis J:14980
absent frontal bone J:14980
absent sesamoid bone of gastrocnemius J:14980
absent sternum body J:14980
delayed bone ossification J:75733
delayed endochondral bone ossification J:14980
dilated lateral ventricle J:75733
duplex kidney J:5191
ectopic ovary J:5191
ectopic testis J:5191
enlarged kidney J:5191
enlarged maxillary zygomatic process J:14980
eyelids open at birth J:75733
failure of endochondral bone ossification J:14980
failure of intramembranous bone ossification J:14980
failure of sternum ossification J:14980
fused carpal bones J:14980
fused tarsal bones J:14980
hydronephrosis J:5191
hydroureter J:5191
intracranial hemorrhage J:5191, J:75733
neonatal lethality, complete penetrance J:75733
non-obstructive hydrocephaly J:75733
respiratory failure J:75733
short basicranium J:14980, J:75733
short humerus J:14980
short mandible J:75733
short radius J:14980
short snout J:75733
short ulna J:14980
small Meckel's cartilage J:75733
Foxc1hith/Foxc1hith
involves: C57BL/6J 		abnormal brain meninges morphology J:157301
abnormal cerebral cortex morphology J:157301
abnormal forebrain morphology J:157301
abnormal neuron differentiation J:157301
abnormal neuron proliferation J:157301
abnormal stratification in cerebral cortex J:157301
Foxc1hith/Foxc1hith
involves: C57BL/6J * FVB/N 		abnormal basement membrane morphology J:136459
abnormal cerebral cortex morphology J:136459
abnormal cortical marginal zone morphology J:136459
abnormal eye morphology J:136459
abnormal frontal bone morphology J:136459
abnormal hippocampus morphology J:136459
abnormal iris morphology J:136459
abnormal lens morphology J:136459
abnormal meninges morphology J:136459
abnormal neocortex morphology J:136459
abnormal radial glial cell morphology J:136459
absent corpus callosum J:136459
absent eye anterior chamber J:136459
ectopic neuron J:136459
hydrocephaly J:136459
increased cornea thickness J:136459
microphthalmia J:136459
radial glial endfoot detachment J:136459
Foxc1hith/Foxc1hith
Tg(Rr291-lacZ)#Mekk/0
involves: C57BL/6J * FVB/N 		abnormal cerebral cortex morphology J:136795
Foxc1hith/Foxc1tm1Blh
involves: 129S6/SvEvTac * C57BL/6J 		abnormal brain meninges morphology J:157301
abnormal cerebral cortex morphology J:157301
abnormal forebrain morphology J:157301
abnormal neuron differentiation J:157301
abnormal neuron proliferation J:157301
abnormal stratification in cerebral cortex J:157301
Foxc1tm1.1Tsku/Foxc1tm1.1Tsku
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL * Tac:NIHBS 		abnormal eye morphology J:188816
absent eye anterior chamber J:188816
hydrocephaly J:188816
increased cornea thickness J:188816
Foxc1tm1Blh/Foxc1+
129S6/SvEvTac-Foxc1tm1Blh 		abnormal anterior eye segment morphology J:61775
abnormal canal of Schlemm morphology J:61775
abnormal cornea morphology J:61775
abnormal iridocorneal angle J:61775
abnormal placement of pupils J:61775
abnormal trabecular meshwork morphology J:61775
irregularly shaped pupil J:61775
Foxc1tm1Blh/Foxc1+
B6.Cg-Foxc1tm1Blh 		abnormal aqueous drainage system morphology J:82280
hypoplastic trabecular meshwork J:82280
Foxc1tm1Blh/Foxc1+
involves: 129S6/SvEvTac * Black Swiss 		abnormal anterior eye segment morphology J:61775
abnormal canal of Schlemm morphology J:61775
abnormal iridocorneal angle J:61775
abnormal iris morphology J:61775
abnormal iris pigment epithelium J:61775
abnormal placement of pupils J:61775
abnormal trabecular meshwork morphology J:61775
iris hypoplasia J:61775
iris stroma hypoplasia J:61775
irregularly shaped pupil J:61775
Foxc1tm1Blh/Foxc1+
involves: 129S6/SvEvTac * C57BL/6J 		abnormal anterior eye segment morphology J:61775
abnormal canal of Schlemm morphology J:61775
abnormal cornea morphology J:61775
abnormal iridocorneal angle J:61775
abnormal iris morphology J:61775
abnormal line of Schwalbe morphology J:61775
abnormal placement of pupils J:61775
abnormal trabecular meshwork morphology J:61775
anterior iris synechia J:61775
cataract J:61775
irregularly shaped pupil J:61775
normal vision/eye phenotype J:61775
Foxc1tm1Blh/Foxc1+
involves: 129S6/SvEvTac * CAST/Ei 		abnormal canal of Schlemm morphology J:61775
abnormal iridocorneal angle J:61775
abnormal trabecular meshwork morphology J:61775
normal vision/eye phenotype J:61775
Foxc1tm1Blh/Foxc1tm1Blh
involves: 129S6/SvEvTac 		abnormal brain meninges morphology J:157301
abnormal cerebral cortex morphology J:157301
abnormal forebrain morphology J:157301
abnormal neuron differentiation J:157301
abnormal neuron proliferation J:157301
abnormal stratification in cerebral cortex J:157301
normal embryo phenotype J:91443
Foxc1tm1Blh/Foxc1tm1Blh
involves: 129S6/SvEvTac * Black Swiss 		abnormal aortic valve cusp morphology J:57677
abnormal aortic valve morphology J:57677
abnormal bone ossification J:48079
abnormal cornea endothelium morphology J:56425
abnormal cornea epithelium morphology J:56425
abnormal cornea morphology J:48079
abnormal craniofacial bone morphology J:48079
abnormal deltoid tuberosity morphology J:48079
abnormal exorbital lacrimal gland morphology J:107208
abnormal fourth pharyngeal arch artery morphology J:57677
abnormal humerus morphology J:48079
abnormal lacrimal gland branching morphogenesis J:107208
abnormal lacrimal gland morphology J:107208
abnormal lacrimal gland physiology J:107208
abnormal maxillary zygomatic process morphology J:48079
abnormal mesonephros morphology J:105944
abnormal nasolacrimal duct morphology J:107208
abnormal ovarian bursa morphology J:105944
abnormal ovarian cortex morphology J:105944
abnormal ovarian follicle morphology J:105944
abnormal ovarian medulla morphology J:105944
abnormal ovary morphology J:105944
abnormal oviduct morphology J:105944
abnormal pharyngeal arch artery morphology J:57677
abnormal primordial germ cell migration J:105944
abnormal pulmonary valve cusp morphology J:57677
abnormal pulmonary valve morphology J:57677
abnormal semilunar valve morphology J:57677
abnormal skeleton morphology J:48079
abnormal sternum ossification J:48079
abnormal tarsal bone morphology J:48079
abnormal testis tunica albuginea morphology J:105944
abnormal vertebral arch morphology J:48079
abnormal xiphoid process morphology J:48079
absent intraorbital lacrimal gland J:107208
absent neurocranium J:48079
absent sternum J:57677
aortic arch coarctation J:57677
bifid ureter J:60834
decreased oocyte number J:105944
disorganized testis cords J:105944
duplex kidney J:60834
enlarged maxillary zygomatic process J:48079
eyelids open at birth J:48079
hydrocephaly J:48079
hydrops fetalis J:57677
impaired ovarian folliculogenesis J:105944
increased cornea epithelium thickness J:56425
interrupted aortic arch J:57677
intracranial hemorrhage J:48079
iris hypoplasia J:48079
neonatal lethality, complete penetrance J:48079, J:57677, J:105944
oocyte degeneration J:105944
ovary cyst J:105944
ovary hemorrhage J:105944
patent ductus arteriosus J:57677
polyovular ovarian follicle J:105944
short oviduct J:105944
small basisphenoid bone J:48079
small gonad J:105944
small lens J:56425
small ovary J:105944
small testis J:105944
small vertebral body J:48079
thick aortic valve cusps J:57677
thick pulmonary valve cusps J:57677
thin ribs J:48079
ventricular septal defect J:57677
Foxc1tm1Tsku/Foxc1tm1Blh
Tg(Tek-cre)1Rwng/0
involves: 129S6/SvEvTac * FVB/N 		abnormal cell migration J:131323
Foxc1tm1Tsku/Foxc1tm1Tsku
involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss * SJL 		no abnormal phenotype detected J:188816
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory