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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Foxf1
forkhead box F1
MGI:1347470
54 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Foxf1em1Vvk/Foxf1+
involves: C57BL/6 * DBA/2 		abnormal gallbladder morphology J:296328
abnormal lung vasculature morphology J:296328
abnormal pulmonary alveolus morphology J:296328
abnormal pulmonary artery morphology J:296328
abnormal pulmonary vein morphology J:296328
absent gallbladder J:296328
decreased angiogenesis J:296328
decreased lung endothelial cell proliferation J:296328
fused right lung lobes J:296328
lung hemorrhage J:296328
lung inflammation J:296328
postnatal lethality, incomplete penetrance J:296328
pulmonary hypoplasia J:296328
small lung J:296328
weight loss J:296328
Foxf1em1Vvk/Foxf1em1Vvk
involves: C57BL/6 * DBA/2 		embryonic lethality, complete penetrance J:296328
Foxf1tm1.1Vvk/Foxf1tm1.1Vvk
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
involves: 129 * C57BL/6 * CBA * SJL 		abnormal vascular branching morphogenesis J:240455
decreased angiogenesis J:240455
decreased vascular endothelial cell number J:240455
Foxf1tm1Pca/Foxf1tm1Pca
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129X1/SvJ * C57BL/6) 		abnormal allantois morphology J:66591
abnormal amnion morphology J:66591
abnormal developmental patterning J:66591
abnormal embryonic tissue morphology J:66591
abnormal extraembryonic mesoderm development J:66591
abnormal extraembryonic tissue morphology J:66591
abnormal hindgut morphology J:66591
abnormal lateral plate mesoderm morphology J:66591
abnormal posterior primitive streak morphology J:66591
abnormal somite development J:66591
abnormal visceral yolk sac morphology J:66591
absent midgut J:66591
absent vitelline blood vessels J:66591
delayed somite formation J:66591
embryonic lethality during organogenesis, complete penetrance J:66591
failure of chorioallantoic fusion J:66591
failure of initiation of embryo turning J:66591
small allantois J:66591
Foxf1tm1Pca/Foxf1tm1Pca
involves: 129P2/OlaHsd * C57BL/6 		abnormal visceral yolk sac mesenchyme morphology J:128367
abnormal visceral yolk sac morphology J:128367
absent vitelline blood vessels J:128367
Foxf1tm1Rhc/Foxf1+
involves: 129P3/J * Black Swiss 		abnormal lung morphology J:70364
abnormal lung saccule morphology J:70364
abnormal lung vasculature morphology J:70364
abnormal surfactant secretion J:70364
impaired lung alveolus development J:70364
lung hemorrhage J:70364
neonatal lethality, incomplete penetrance J:70364
premature death J:70364
respiratory distress J:70364
Foxf1tm1Rhc/Foxf1+
involves: 129P3/J * Black Swiss * CD-1 		abnormal lung bud morphology J:76411
abnormal lung development J:76411
abnormal lung vasculature morphology J:76411
fused right lung lobes J:76411
neonatal lethality, complete penetrance J:76411
Foxf1tm1Rhc/Foxf1tm1Rhc
involves: 129P3/J * Black Swiss 		lethality throughout fetal growth and development, complete penetrance J:70364
Foxf1tm2Rhc/Foxf1+
Tg(Myh11-cre,-EGFP)2Mik/0
involves: C57BL/6 * DBA/2 		abnormal intestinal smooth muscle morphology J:203847
impaired contractility of intestinal smooth muscle J:203847
lethality, incomplete penetrance J:203847
Foxf1tm2Rhc/Foxf1tm2Rhc
Tg(Myh11-cre,-EGFP)2Mik/0
involves: C57BL/6 * DBA/2 		abnormal esophageal smooth muscle morphology J:203847
dilated esophagus J:203847
perinatal lethality, complete penetrance J:203847
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory