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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Foxa1
forkhead box A1
MGI:1347472
14 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Foxa1tm1(cre)Sew/Foxa1+
Mst1rtm1Sew/Mst1rtm1Sew
involves: 129P2/OlaHsd * CD-1 * NIH Black Swiss 		decreased susceptibility to bacterial infection J:105979
Foxa1tm1Khk/Foxa1+
Foxa2tm1Khk/Foxa2tm1Khk
Tg(Pdx1-cre)6Cvw/0
involves: 129 * C57BL/6 * CBA * SJL 		decreased pancreatic beta cell number J:143476
exocrine pancreas hypoplasia J:143476
pancreas hypoplasia J:143476
pancreatic islet hypoplasia J:143476
postnatal lethality, complete penetrance J:143476
Foxa1tm1Khk/Foxa1tm1Khk
Foxa2tm1Khk/Foxa2+
Tg(Pdx1-cre)6Cvw/0
involves: 129 * C57BL/6 * CBA * SJL 		normal endocrine/exocrine gland phenotype J:143476
normal homeostasis/metabolism phenotype J:143476
Foxa1tm1Khk/Foxa1tm1Khk
Foxa2tm1Khk/Foxa2tm1Khk
Tg(Alb1-cre)1Khk/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		decreased incidence of tumors by chemical induction J:181296
increased hepatocellular carcinoma incidence J:181296
increased incidence of tumors by chemical induction J:181296
Foxa1tm1Khk/Foxa1tm1Khk
Foxa2tm1Khk/Foxa2tm1Khk
Tg(Pdx1-cre)6Cvw/0
involves: 129 * C57BL/6 * CBA * SJL 		abnormal pancreas development J:143476
abnormal pancreas morphology J:143476
decreased pancreatic beta cell number J:143476
exocrine pancreas hypoplasia J:143476
hyperglycemia J:143476
pancreas hypoplasia J:143476
pancreatic islet hypoplasia J:143476
postnatal lethality, complete penetrance J:143476
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory